A5078949229- Cancer Research and Treatments
- Cancer-related Molecular Pathways
- Virus-based gene therapy research
- Metabolism and Genetic Disorders
- Hemoglobin structure and function
- Enzyme Structure and Function
- Pancreatic and Hepatic Oncology Research
- Pancreatic function and diabetes
- Cell Adhesion Molecules Research
- Protein Structure and Dynamics
- Cellular Mechanics and Interactions
- Mitochondrial Function and Pathology
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- CAR-T cell therapy research
- Drug-Induced Hepatotoxicity and Protection
- Freezing and Crystallization Processes
- Respiratory Support and Mechanisms
- Neuroblastoma Research and Treatments
- Renal and related cancers
- Viral Infections and Immunology Research
- Cancer Treatment and Pharmacology
- COVID-19 Clinical Research Studies
- Viral Infectious Diseases and Gene Expression in Insects
- Liver Disease Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
Universidad Pontificia Bolivariana
2023-2024
Universitat de Barcelona
1991-2013
Institute for Research in Biomedicine
2013
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2013
Hospital Clínic de Barcelona
2007
Instituto de Química y Fisicoquímica Biológicas
2001
Scriptorium
1991
Shiga University of Medical Science Hospital
1991
The University of Tokyo
1991
Nucleoside transporters (NTs) mediate the uptake of nucleosides and nucleobases across plasma membrane, mostly for salvage purposes. The canonical NTs belong to two gene families, SLC29 SLC28. former encode equilibrative nucleoside transporter proteins (ENTs), which facilitative diffusion natural with broad selectivity, whereas latter concentrative (CNTs), are sodium-coupled show high affinity substrates variable selectivity. These expressed in most cell types, exhibiting apparent functional...
Mitochondrial malate dehydrogenase shows a complex regulation pattern in the presence of citrate. Previously published results indicate that this enzyme is activated by citrate NAD(+)----NADH direction and inhibited opposite direction. Moreover, high concentrations L-malate or oxaloacetate produce deviations from Michaelis-Menten behaviour. Results reported paper clearly show both activates inhibits mitochondrial same (NAD(+)----NADH), reaction medium, depending on substrate concentration....
Fetoacinar pancreatic (FAP) protein is a specific component of the human exocrine pancreas that may have role in differentiation and transformation this organ. In order to set out model for studies on regulation FAP, 47 established cell lines from cancer different origins were tested FAP expression using monoclonal antibody J28 (Mab J28). Only two, both pancreatic, positive. This finding supports already reported specificity antigen. Strongest was shown by BxPC-3 line, derived moderately...
We analyzed the differential gene expression in pancreatic cancer cell line NP-18 upon induction of apoptosis caused by cyclin-dependent kinase inhibition triggered either overexpression tumor suppressor <i>p16<sup>INK4A</sup></i>using an adenoviral construction or incubation with chemical inhibitors, roscovitine olomoucine. Screening was performed using cDNA arrays from Clontech that allowed determination 1,176 genes specifically related cancer. The analysis carried...
Background : Pancreatic cancer, the fifth leading cause of adult cancer death in Western countries, lacks early detection, and displays significant dissemination ability. Accumulating evidence shows that integrin-mediated cell attachment to extracellular matrix induces phenotypes signaling pathways regulate tumor growth migration. Methods In view these findings, we examined role β 3 pancreatic by generating two stable -expressing human lines characterizing their behavior vitro vivo. Results...
The p16 I N K locus encode for 2 tumor suppressor genes commonly lost during transformation and acquisition of malignancy processes. product gene is a CDK inhibitor that constrains cell cycle progression in response to different proliferative stresses participates cell-environment signaling pathways. Restitution function has showed potent antitumoral activity new therapy approaches-and should be taken into consideration future design rationale specific therapeutic strategies against cancer.
Abstract Funding Acknowledgements Type of funding sources: None. Background Present guidelines endorse complete removal cardiovascular-implantable electronic devices (pacemakers/defibrillators), including extraction intracardiac electrodes, not only for systemic infections but also localized "pocket infections." Objectives We evaluated the efficacy delivering "Continuous, In-situ-Targeted, ultra-high concentration Antibiotics" (CITA) into infected subcutaneous device-pocket, obviating need...
Introducción: La sarcoidosis es un desorden inflamatorio sistémico caracterizado por la formación de granulomas no caseificados en distintos órganos, que afecta principalmente pulmón y piel. Sus principales manifestaciones son las adenopatías hiliares paniculitis, respectivamente. El tratamiento depende presentación clínica el grado severidad. Existen pocos estudios locales estudien características enfermedad nuestra población. Objetivo: Determinar ociodemográficas clínicas pacientes con dos...
El objetivo de esta revisión sistemática fue estimar la efectividad N-acetilcisteína en el tratamiento hepatotoxicidad por antituberculosos; se incluyeron ensayos clínicos controlados aleatorizados, sin restricciones idioma ni estado publicación; tuvieron cuenta estudios publicados hasta diciembre 2022. Búsqueda bases datos bibliográficas: CENTRAL, CINAHL, LILACS, MEDLINE, Pubmed, Scielo, Scopus y Web of Science; 33 artículos encontrados, uno cumplió los criterios inclusión con bajo riesgo...
e14601 Background: Treatment of pancreatic cancer remains challenging and mostly palliative. Gemcitabine erlotinib has shown modest benefit compared with gemcitabine alone. The efficacy anti-EGFR therapies been probably hampered by the absence biomarker selected strategies. Activation compensatory pathways, such as Her-2 or IGF-IR signaling, should be considered. Methods: From eleven tumorgrafts only one shows moderate to high levels both EGFR HER2 very low IGF-1R activity. other models...
15019 Background: Efforts to find new therapies for human pancreatic ductal adenocarcinoma (PDAC) have not resulted in clear improvements on patient survival. Better knowledge of resistance mechanisms and redefiniton molecular targets is essential design more efficient therapies. The multifactorial origin PDAC points combined strategies as the therapy choice, though effective development such hampered by lack optimal preclinical models. We generated validated optimized models direct...
Initial rate kinetic studies of lactate dehydrogenase with ketomalonate and NADH as substrates suggest that this enzymatic system is adapted to a rapid equilibrium ordered bi-bi ternary complex mechanism. The application the reaction product inhibition method reveals existence enzyme-NADH-hydroxy-malonate enzyme-NAD+-ketomalonate abortive complexes. This behaviour confirmed by differential induced several alternate products on pyruvate-lactate dehydrogenase-NADH ketomalonate-lactate systems.