A5087367778- Diet and metabolism studies
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer, Stress, Anesthesia, and Immune Response
- Adenosine and Purinergic Signaling
- Immune cells in cancer
- Amino Acid Enzymes and Metabolism
- Immune Cell Function and Interaction
- Drug Transport and Resistance Mechanisms
- Cancer, Hypoxia, and Metabolism
- Cytokine Signaling Pathways and Interactions
- Monoclonal and Polyclonal Antibodies Research
- Pharmacological Effects and Toxicity Studies
- Cancer Immunotherapy and Biomarkers
- Cancer Research and Treatments
- Gut microbiota and health
- Autophagy in Disease and Therapy
- TGF-β signaling in diseases
- Pancreatic function and diabetes
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- Sirtuins and Resveratrol in Medicine
- CAR-T cell therapy research
- Chronic Lymphocytic Leukemia Research
- Adipose Tissue and Metabolism
- HER2/EGFR in Cancer Research
Institut d'Investigació Sanitària Pere Virgili
2021-2025
Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas
2022-2025
Instituto de Salud Carlos III
2012-2025
Vall d'Hebron Hospital Universitari
2019
Vall d'Hebron Institute of Oncology
2017
Institute for Research in Biomedicine
2013
Universitat de Barcelona
2004-2013
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2012-2013
Institut de Biomedicina de la Universitat de Barcelona
2012
Centro de Investigación Biomédica en Red
2010
Abstract Cancer response to immunotherapy depends on the infiltration of CD8 + T cells and presence tumor-associated macrophages within tumors. Still, little is known about determinants these factors. We show that LIF assumes a crucial role in regulation cell tumor infiltration, while promoting protumoral macrophages. observe blockade tumors expressing high levels decreases CD206, CD163 CCL2 induces CXCL9 expression The releases epigenetic silencing triggering infiltration. combination...
Abstract Background Succinate is produced by both human cells and gut bacteria couples metabolism to inflammation as an extracellular signaling transducer. Circulating succinate elevated in patients with obesity type 2 diabetes linked numerous complications, yet no studies have specifically addressed the contribution of microbiota systemic or explored consequences reducing intestinal levels this setting. Results Using germ-free microbiota-depleted mouse models, we show that a significant...
Leukemia inhibitory factor (LIF) is a multifunctional cytokine with numerous reported roles in cancer and thought to drive tumor development progression. Characterization of LIF clinical-stage inhibitors would increase our understanding as therapeutic target.We first tested the association expression transcript signatures representing multiple processes regulating Next, we developed MSC-1, high-affinity antibody that potently inhibits signaling it immune competent animal models cancer.LIF...
Abstract Purpose Recent studies point to adipose-derived stem cells (ASCs) as a link between obesity and cancer. We aimed determine whether survivin, which is highly secreted by ASCs from subjects with obesity, might drive pro-tumoral phenotype in macrophages. Methods The effect of ASC conditioned medium on the macrophage was assessed expression studies. Survivin intracellular localization internalization were examined subcellular fractionation immunofluorescence, respectively. Loss-...
Nucleoside transporters (NTs) mediate the uptake of nucleosides and nucleobases across plasma membrane, mostly for salvage purposes. The canonical NTs belong to two gene families, SLC29 SLC28. former encode equilibrative nucleoside transporter proteins (ENTs), which facilitative diffusion natural with broad selectivity, whereas latter concentrative (CNTs), are sodium-coupled show high affinity substrates variable selectivity. These expressed in most cell types, exhibiting apparent functional...
Abstract Concentrative nucleoside transporter 2 (CNT2) is a high‐affinity adenosine that may play physiological roles beyond salvage. Previous reports relate CNT2 function to modulation of purinergic signaling and energy metabolism in intestinal liver parenchymal cells (Duflot et al., 2004, Mol Cell Biol 24:2710–2719; Aymerich 2006, J Sci 119:1612–1621). In the present study, further examine link between metabolism, protein partners were identified using bacterial two‐hybrid GST pull‐down...
CNT2 (concentrative nucleoside cotransporter) is a plasma membrane high-affinity Na+-coupled adenosine transporter, also localized in intracellular structures. This transporter protein may play additional roles other than salvage, since it has recently been shown to be under purinergic control via KATP channels, by mechanism that does not seem involve changes its subcellular localization. In an attempt identify the agents promote trafficking, bile acids were found increase CNT2-related...
The concentrative nucleoside transporter (CNT) family (SLC28) has three members: SLC28A1 (CNT1), SLC28A2 (CNT2) and SLC28A3 (CNT3). CNT1 CNT2 transporters are co-expressed in liver parenchymal cells macrophages, two suitable models which to study cell cycle progression. Despite initial observations suggesting that these proteins might contribute salvage during proliferation, their subcellular localization regulatory properties suggest alternative roles physiology. In particular, is a...
Abstract Dysfunctional adipocyte precursors have emerged as key determinants for obesity‐ and aging‐related inflammation, but the mechanistic basis remains poorly understood. Here, we explored dysfunctional adipose tissue of elderly obese individuals focusing on metabolic inflammatory state human adipose‐derived mesenchymal stromal cells (hASCs), sirtuins, which link metabolism inflammation. Both obesity aging impaired differentiation potential hASCs had a different impact their...
Abstract Leukemia Inhibitory Factor (LIF) is a member of the IL-6 family cytokines and involved in many physiological pathological processes including promotion an immunosuppressive environment to support embryo implantation, down-regulation autoimmune regulation stem cell homeostasis differentiation. In cancer, LIF hypothesized have complex role tumor development progression, creating microenvironment as well promoting activity cancer initiating cells (CICs). highly expressed subset tumors...
<p>Supplementary Figure 1. Transcriptomic analysis demonstrates an enrichment of immunological pathways in high LIF tumors. Supplementary 2. transcripts are associated with a panel immunosuppressive macrophage/myeloid signatures across human tumor indications. 3. specifically suppressive macrophage 4. tend to be highly expressed aggressive 5. drives polarization macrophages. 6. RNAseq induced gene sets macrophages predict poor patient outcome and correlate 7. Structural MSC-1 reveals...
<div>AbstractPurpose:<p>Leukemia inhibitory factor (LIF) is a multifunctional cytokine with numerous reported roles in cancer and thought to drive tumor development progression. Characterization of LIF clinical-stage inhibitors would increase our understanding as therapeutic target.</p>Experimental Design:<p>We first tested the association expression transcript signatures representing multiple processes regulating Next, we developed MSC-1, high-affinity antibody that...
<div>AbstractPurpose:<p>Leukemia inhibitory factor (LIF) is a multifunctional cytokine with numerous reported roles in cancer and thought to drive tumor development progression. Characterization of LIF clinical-stage inhibitors would increase our understanding as therapeutic target.</p>Experimental Design:<p>We first tested the association expression transcript signatures representing multiple processes regulating Next, we developed MSC-1, high-affinity antibody that...
<p>Supplementary Figure 1. Transcriptomic analysis demonstrates an enrichment of immunological pathways in high LIF tumors. Supplementary 2. transcripts are associated with a panel immunosuppressive macrophage/myeloid signatures across human tumor indications. 3. specifically suppressive macrophage 4. tend to be highly expressed aggressive 5. drives polarization macrophages. 6. RNAseq induced gene sets macrophages predict poor patient outcome and correlate 7. Structural MSC-1 reveals...