A5083911337- Diet and metabolism studies
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer, Stress, Anesthesia, and Immune Response
- Gut microbiota and health
- Urbanism, Landscape, and Tourism Studies
- Employment, Labor, and Gender Studies
- Adipose Tissue and Metabolism
- French Urban and Social Studies
- Photographic and Visual Arts
- Social Sciences and Policies
- Tryptophan and brain disorders
- Human Rights and Immigration
- Diversity and Impact of Dance
- History, Culture, and Society
- Mitochondrial Function and Pathology
- Galician and Iberian cultural studies
- Art, Politics, and Modernism
- Literature, Musicology, and Cultural Analysis
- Aging, Elder Care, and Social Issues
- Doping in Sports
- Architecture and Art History Studies
- ATP Synthase and ATPases Research
- Epigenetics and DNA Methylation
- Physical education and sports games research
- Central Asia Education and Culture
Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas
2019-2023
Institut d'Investigació Sanitària Pere Virgili
2019-2023
Universitat Rovira i Virgili
2019-2023
Instituto de Salud Carlos III
2022-2023
Ajuntament de Barcelona
2022
TiGenix (Spain)
2022
FC Barcelona
2021
Gut microbiota communities have coevolved for millions of years in a symbiotic relationship with their mammalian hosts. Elucidating and understanding the molecular mechanisms by which interacts its host how this contributes to ecosystem homeostasis is crucial. One these relationships so-called chemical crosstalk between metabolisms, includes poorly explored epigenetic regulation tissues, comprising DNA methylation histone marks, metabolic activity gut response changes diet. Epigenetic marks...
Abstract Background Succinate is produced by both human cells and gut bacteria couples metabolism to inflammation as an extracellular signaling transducer. Circulating succinate elevated in patients with obesity type 2 diabetes linked numerous complications, yet no studies have specifically addressed the contribution of microbiota systemic or explored consequences reducing intestinal levels this setting. Results Using germ-free microbiota-depleted mouse models, we show that a significant...
Mitochondria constantly undergo fusion and fission events, referred as mitochondrial dynamics, which determine architecture bioenergetics. Cultured cell studies demonstrate that dynamics are acutely regulated by phosphorylation of the orchestrator dynamin-related protein 1 (Drp1) at S579 or S600. However, physiological impact crosstalk these sites is poorly understood. Here, we describe functional interrelation between S600 in vivo their role on remodeling. Mice carrying a homozygous Drp1...
Metabolic plasticity is the ability of a biological system to adapt its metabolic phenotype different environmental stressors. We used whole-body and tissue-specific phenotypic, functional, proteomic, metabolomic transcriptomic approach systematically assess in diet-induced obese mice after combined nutritional exercise intervention. Although most obesity overnutrition-related pathological features were successfully reverted, we observed high degree dysfunction visceral white adipose tissue,...
Abstract Metabolic plasticity is the ability of a biological system to adapt its metabolic phenotype different environmental stressors. We used whole-body and tissue-specific phenotypic, functional, metabolomic transcriptomic approach systematically assess in diet-induced obese mice after combined nutritional exercise intervention. Although most pathological features were successfully reverted, we observed high degree dysfunction irreversibility visceral white adipose tissue, characterised...
Abstract Metabolites play a central role in the chemical crosstalk between metabolism and epigenetic marks. Epigenetically relevant metabolites are substrates, products cofactors that can act as activators or inhibitors of enzymes, which control gene expression by adding removing marks DNA, RNA histones. Diet composition, biosynthetic pathways encoded gut microbiome host genome main sources these for mammals. Despite increasing interest study ‘microbiota-nutrient metabolism-host axis’ to...
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