A5069352162- Gastrointestinal motility and disorders
- Gastroesophageal reflux and treatments
- Eosinophilic Esophagitis
- Helicobacter pylori-related gastroenterology studies
- Child Nutrition and Feeding Issues
- Congenital gastrointestinal and neural anomalies
- Metabolism and Genetic Disorders
- Pharmaceutical studies and practices
- Therapeutic Uses of Natural Elements
- Pharmacological Effects and Toxicity Studies
- Inflammatory Bowel Disease
- Diet and metabolism studies
- Microscopic Colitis
- Esophageal and GI Pathology
- Epilepsy research and treatment
- Gestational Diabetes Research and Management
- Intestinal and Peritoneal Adhesions
- Gastric Cancer Management and Outcomes
- Celiac Disease Research and Management
- Pharmacogenetics and Drug Metabolism
- Anesthesia and Sedative Agents
- Antibiotics Pharmacokinetics and Efficacy
- Diverticular Disease and Complications
- Analytical Methods in Pharmaceuticals
- Pelvic floor disorders treatments
Hospital Clínico San Carlos
2014-2025
Universidad Complutense de Madrid
2008-2025
Organización Nacional de Trasplantes
2023
TIE Kinetix (Germany)
2023
Hospital Universitario 12 De Octubre
2023
Université de Montréal
1990-2023
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos
2014-2021
Central University of Venezuela
1995-2017
Centre Hospitalier Universitaire Sainte-Justine
1992-2015
Mayo Clinic
2008-2014
Data on patients with inflammatory bowel diseases (IBD) who have had 2019 novel coronavirus (SARS-CoV-2) disease (COVID-19) are needed.To report the clinical characteristics, including gastrointestinal symptoms, of COVID-19 in IBD patients, and to assess risk IBD.This case series included consecutive laboratory-confirmed COVID-19. Age-adjusted cumulative incidences were compared general population Madrid region.Through April 8, 12 1918 diagnosed The average age was 52 years, 75% female 58.3%...
Summary Aim : To measure the prevalence of gastro‐oesophageal reflux symptoms and to identify associated factors in a representative sample Spanish population. Methods A telephone survey 2500 subjects was performed using validated questionnaire. The association (defined as presence heartburn or acid regurgitation) their clinical characteristics with potential risk summarized odds ratios (OR) obtained by multiple logistic regression. Results response rate 71.2%. annual 31.6%[95% confidence...
The pharmacokinetics of the enantiomers ibuprofen were investigated after oral administration a single 7.6 +/‐ 0.3 mg kg‐1 dose racemate in 11 infants. Mean (+/‐ s.d.) half‐lives 1.6 0.5 h for S(+) and 1.5 R(‐) mean AUC values 31.5 14.3 l‐1 36.6 13.8 R(‐). Since plasma concentrations active S(+)‐isomer lower than those reported adults, higher dosage might be required
The objective of this study was to determine the impact nausea and vomiting pregnancy (NVP) other determinants on generic NVP-specific health-related quality life (QOL) in first trimester pregnancy.Prospective study.Centre Hospitalier Universitaire (CHU) Sainte-Justine or René-Laennec clinics, Montreal, Quebec, Canada.Pregnant women attending clinics for their prenatal care from 2004 2006. Women were eligible if they > =18 years age < =16 weeks gestation at time visit.After visit, asked fill...
The prevalence of diagnosed gastroparesis is 24.2/100,000 inhabitants, but a large group people with gastroparesis-like symptoms have never had gastric emptying (GE) test. Some them may undiagnosed gastroparesis. Our aim was to estimate the hidden in community.The study conducted 2 parts: (1) Patients referred for scintigraphic GE test completed validated questionnaire (Bowel Disease Questionnaire). Multiple linear regression models predict hours and 4 rates were developed. (2) A revised...
In high or moderate risk populations, periodic surveillance of patients at progression from gastric precursor lesions (PL) to cancer (GC) is the most effective strategy for reducing burden GC. Incomplete type intestinal metaplasia (IIM) may be considered as best candidate, but it still controversial and more research needed. To further assess subtypes IM predictors GC occurrence.A follow-up study was carried-out including 649 patients, diagnosed with PL between 1995-2004 in 9 participating...
Prevalence of gastroesophageal reflux symptoms (GERS) increases during pregnancy, but there are no longitudinal studies on western populations examining their incidence in each trimester. Our aim was to describe the natural history GERS pregnancy and ascertain whether might be associated with a higher risk developing 1 yr postpartum.Pregnant women (<12 wk gestation) age-matched controls were included. A telephone survey conducted, covering pregnant at 12, 24, 36 gestation postpartum, using...
<b>Aim:</b> To investigate whether the maternal use of different doses inhaled corticosteroids (ICSs) during first trimester pregnancy for treatment asthma increases risk congenital malformations in offspring. <b>Methods:</b> From linkage three administrative Canadian databases, a cohort 4561 pregnancies from women with who delivered between 1990 and 2000 was reconstructed. A two-stage sampling design used to acquire additional data woman's medical chart. Cases malformation were identified...
The natural history of fecal incontinence (FI) in community subjects is uncertain and the onset rate unknown. aim study to estimate prevalence, new-onset rate, risk factors for FI subjects.A random sample 2,400 aged > or =50 years was surveyed 1993, using a validated questionnaire. Responders were recontacted 2003. defined as self-reported problems with leakage stool. Onset calculated proportion without who became new cases. Logistic regression models constructed identify predictive...
Abstract Background Randomized trials have confirmed the efficacy of prucalopride for treatment chronic constipation up to 12 weeks. This study aimed assess over a 24‐week period (ClinicalTrials.gov: NCT01424228). Methods Adults with and ≤2 spontaneous complete bowel movements ( SCBM s)/week were randomized receive 2 mg or placebo daily 24 The primary endpoint was proportion patients achieving mean ≥3 s/week period, assessed using e‐diaries. Secondary outcomes safety parameters throughout...
The association between typical and atypical symptoms of gastroesophageal reflux (GER) has received little attention in population-based studies. This study therefore sought to examine the prevalence symptoms, their with GER Spain.A telephone survey using a validated questionnaire was conducted 2002 on 2500 subjects aged 40-79 years, randomly selected from general population Spain. included items (heartburn acid regurgitation) several (chest pain, dysphagia, belching, dyspepsia, globus,...
Background There are no existing studies that provide data regarding the epidemiology of, and risk factors for, fecal impaction, either in general population or any sub-group of people. Objective Estimate prevalence associated with impaction on a representative sample institutionalized elderly population. Design Two-phase study. Phase 1: pilot study validating methodology which all residents single nursing home participated. 2: national multi-center cross-sectional Setting 34 randomly...
Chronic constipation (CC) is common in the community but surprisingly little known about relevant gastro-intestinal (GI) and non-GI co-morbidities.The purpose of this study was to assess epidemiology CC particular provide new insights into co-morbidities linked condition.In a prospective, population-based nested case-control study, cohort randomly selected residents (n = 8006) were mailed validated self-report gastrointestinal symptom questionnaire. defined according Rome III criteria....
Administering the anesthetic propofol after a brief reminder reduces retrieval of established emotional memory 24 hours later.
Laparoscopic Nissen fundoplication (LNF) is the gold standard of antireflux surgery. Up to 30% patients experience symptoms after surgery, with insufficient information available. The main objective evaluate epidemiological, clinical, and functional factors associated LNP. a retrospective case-control study including 79 operated (2015-2024). We assessed relationship between epidemiological data, tests, imaging results occurrence LNF. 24 asymptomatic 55 symptomatic were included. Functional...
Excess weight is a risk factor of gastroesophageal reflux symptoms (GERS) in population-based studies but it unknown to what extent short-term gain (occurring months) associated with the development GERS. Our aim examine association GERS.A phone interview was conducted 2,500 persons aged 40-79 yr selected at random from general population Spain. The Gastroesophageal Reflux Questionnaire used identify onset, frequency, and severity We also assessed weight, height, 1-yr change (classified as...