Introduction The 2021 World Health Organization (WHO) classification of tumors the central nervous system (CNS) has introduced significant changes to tumor taxonomy. One most in isolation isocitrate dehydrogenase (IDH) mutant forms glioblastoma multiforme (GBM) into separate entities, as well no longer allowing for entries be classified not otherwise specified (NOS). As a result, this entity now includes only aggressive adult-type tumors. such, established prognostic factors apply, they form...

Introduction Head and neck cancer (HNC) comprises a diverse group of oncological entities, originating from various tissue types organ localizations, situated in the topographical regions head (H&N). This single institution retrospective study was aimed at establishing HNC patient demographics categorizing individual incidence H&N malignancies, regarding their origin main histopathological type. Materials methods All histologically verified cases tertiary referral center were...

The term “spaces” refers to the areas delimited by at least two independent fasciae and filled with areolar connective tissue. However, there is discrepancy regarding spaces their limits between clinical anatomy gynecologic surgery, as not every avascular space described in literature fasciae. Moreover, new surgical planes have been developed after adoption of laparoscopy nerve-sparing gynecological procedures. Avascular are useful anatomical landmarks retroperitoneal anatomic pelvic surgery...

Background Glioblastoma multiforme (GBM) is a class IV astrocytic tumor, the most malignant of four groups World Health Organization (WHO) tumors with differentiation. Aim The aim this study was to estab-lish whether correlation exists between Ki-67 index differentiation, WHO grade, and patient survival. Materials methods A retrospective non-clinical approach selection chosen for study. total 47 patients diagnosed treated CNS differentiation in St. Marina University Hospital, Varna,...

In nearly a year since the first reported cases of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome 2 (SARS-CoV-2), lot has been established about virus. Correlates in regards to biology and cellular effects SARS-CoV-2 have brought explanations clinical manifestations possible therapeutic modalities. However, despite discoveries made, tropism not yet fully established, nor all aspects COVID-19. Herein we report gross histological findings two diseased...

Introduction The novel coronavirus variant - severe acute respiratory distress syndrome 2 (SARS-CoV-2) and the disease it causes clinically (novel 2019 or COVID-19) have placed medical science into a frenzy due to significant morbidity mortality, as well myriad of clinical complications developing direct result infection. most notable one changes in COVID-19 develops lungs. Materials methods All cases real-time polymerase chain reaction (rtPCR)-proved subjected autopsy were withdrawn from...

Vulvar cancer (VC) is a rare disease, of which the squamous vulvar carcinomas (SVCs) are most common histological subtype. SVC often associated with human papillomavirus (HPV) infection. HPV- positive SVCs multifocal, typically have non-keratinizing morphology, presence koilocytes and tend to arise in younger women (<50 years), smokers. The "hit run" theory has been subject longstanding curiosity tumor virology. scenario suggests that viruses an activating role development viral genome may...

Introduction Intracranial tumors (ICTs) are a diverse group of malignancies that pose an immediate threat to patients' lives, no matter their local or metastatic origin, benign malignant nature. These lesions have severe clinical courses and need be diagnosed treated as soon possible, with pathological verification being the pivotal moment in process determining curative modalities. Aim The aim this study was compare incidence histologically confirmed ICTs Eastern Bulgaria, based on type...

Corona mortis (CMOR) is a heterogeneous and often dubious term that causes much confusion in medical literature, especially regard to its modern day significance pelvic surgery. Some authors define CMOR as any abnormal anastomotic vessel between the external iliac obturator vessels, whereas others it coursing over superior pubic branch, regardless whether vascular anastomosis, an accessory related system or terminal small vessel. There no standard classification of vessels variations,...

Ameloblastoma is a rare low-grade odontogenic tumor of epithelial origin. The World Health Organization (WHO) has defined malignant ameloblastoma (MA) as histologically benign-appearing that metastasized. Treatment the primary usually consists radical excision and adjuvant radiotherapy. Chemotherapy should be used to treat metastases due its indolent clinical course. Presented here case 43-year-old woman who was admitted hospital in 2006 with large mass involving neck left mandible. had...

First described by a French physician Armand Trousseau, the Trousseau sign of malignancy is classic example paraneoplastic syndrome, caused adenocarcinomas predominantly stomach, pancreas, and lung. The condition presents as recurring migrating episodes thrombophlebitis that can involve upper lower limbs, thoracic abdominal wall, major blood vessels abdomen. These may lead to detachment thrombus formation pulmonary thromboembolism (PTE), often proving fatal for patient. Herein we present...

Acute necrotizing encephalitis (ANE) is a rare complication of viral respiratory tract infections, with specific histological changes. The condition most commonly described in the pediatric population, however, it can also develop elderly, some genetic factors being as contributory. Herein, we report autopsy finding patient infection, complicated ANE. was 77-year-old female multiple comorbidities living social home. For two months prior, she had been hospitalized cerebral infarction, and...

Doxorubicin is an anthracycline antibiotic that used for the treatment of various types cancer. However, its clinical usage limited due to potential life-threatening adverse effects, such as cardio- and nephrotoxicities. Nonetheless, simultaneous administration doxorubicin antioxidants, those found in green tea leaves, could reduce cardiac renal tissue damage caused by oxidative stress. The methylxanthine fraction isolated from Bancha leaves were tested vitro antioxidant activity vivo...

Introduction. Ovarian carcinosarcoma (OCS), also known as malignant mixed Müllerian tumour (MMMT), is one of the rarest histological subtypes ovarian cancer. It an aggressive with a dismal prognosis—the median survival patients less than two years. The rarity disease generates many controversies about histogenesis, prognostic factors and treatment OCS. Histologically, OCS composed epithelial sarcomatous component. Case report. In present case, patient bilateral cysts bulky paraaortic lymph...

INTRODUCTION : The diagnosis and treatment of intracranial tumors requires a multidisciplinary approach. A key moment in this process is the pathological verification tumor type. This process, although aided by immunohistochemistry (IHC), can often be difficult misleading. MATERIALS AND METHODS Ten histologically confirmed cases glioblastoma multiforme (GBM) were reviewed for their IHC reaction with anti-glial fibrillary acidic protein (GFAP) glial marker CK AE1/AE3 antibody cocktail, whose...