A5081868306- Reproductive System and Pregnancy
- Endometriosis Research and Treatment
- Gynecological conditions and treatments
- Uterine Myomas and Treatments
- Endometrial and Cervical Cancer Treatments
- Pluripotent Stem Cells Research
- Preterm Birth and Chorioamnionitis
- Pregnancy and preeclampsia studies
- Sperm and Testicular Function
- Reproductive Physiology in Livestock
- Renal and related cancers
- Genetics and Neurodevelopmental Disorders
- Eosinophilic Disorders and Syndromes
- Pregnancy and Medication Impact
- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Cardiac tumors and thrombi
- Tuberous Sclerosis Complex Research
- Reproductive Biology and Fertility
- Mesenchymal stem cell research
- COVID-19 Impact on Reproduction
- Reproductive tract infections research
Women’s Health Care
2024
Background: The Notch signaling pathway is an important regulator of stem cell activity in various tissues, including the central nervous system. It has been implicated neurodevelopmental processes, neuronal differentiation and synaptic plasticity. Research suggests that its expression may be associated with certain epileptogenic lesions, particularly those origin. aim this study was to investigate Notch-1 brain biopsies from cases pharmacoresistant epilepsy. Methods: Here, we used...
Adenomyosis and endometriosis are distinct gynecological disorders characterized by ectopic growth of endometrial tissue. Their etiology remains unclear, but stem cells have been implicated in both. The aim this study was to investigate compare the quantity NOTCH1+ CD117+ adenomyosis lesions. Immunohistochemical staining endometrium biopsies using antibodies against NOTCH1 CD117 performed. spatial distribution stromal positive for these markers were determined compared between Additionally,...
Abstract The present study aimed to identify, quantify and compare the quantities of very small embryonic-like (VSEL) stem cells in two main fractions fresh umbilical cord blood (UCB). To do this, UCB obtained during caesarean section underwent gradient centrifugation. Nucleated isolated from – mononuclear cell layer above gradient, red pellet below were immunofluorescently labelled identify VSELs (CD45 − /CD133 + /SSEA4 ). These then analysed via multiparameter sorting on a flow cytometer...
Abstract Study question Is there a relation between certain T cell subpopulations in the peripheral blood and reproductive outcome patients with recurrent pregnancy loss (RPL)? Summary answer We found that miscarriage RPL is associated low quantities of follicular helper cells (TFH) double-positive (DPT). What known already Previous studies showed that, quantity types immune cells, such as natural killer B has been miscarriages. It also well first trimester characterized by inflammation...
Abstract Study question Is there a relationship between the percentage of peripheral regulatory T cells (Treg) and other cell subtypes in first trimester pregnancy? Summary answer The Treg showed significant positive correlation with quantity follicular helper (TFH). What is known already Regulatory play an essential role process embryo implantation maintenance normal pregnancy. these blood expands during Several studies report importance control inflammatory pathophysiology common adverse...
Abstract Study question Are there any quantitative associations between endometrial macrophages populations and microorganisms’ diversity? Summary answer The quantities spatial distribution of correlated significantly with several microbiome diversity indices. What is known already Numerous studies have linked the relative abundance Lactobacilli a receptive endometrium, while presence multiple other bacterial species has been implicated in implantation failure. Another determinant...
To investigate the quantity of 2 stem cell types in endometrial stroma women undergoing vitro fertilization and their association with steroid hormone signaling implantation success after embryo transfer.Prospective cohort study.Private hospital.A total 109 patients fertilization.Not applicable.Immunohistochemistry staining biopsies taken during midluteal phase using antibodies against NOTCH1 CD117 was performed. The percentage stromal cells positive for these markers determined. link...
It is an acknowledged fact that SARS-CoV-2 exhibits tropism for the human placenta. A possible mechanism of entry into host cells via angiotensin-converting enzyme 2 (ACE2) receptors, which are expressed in trophoblasts, endothelial cells, and macrophages. The present study describes a case spontaneous miscarriage 20th gestational week after maternal infection. placenta various fetal organs were examined structural alterations expression viral nucleocapsid protein several immune cell markers...
Abstract Study question Is there an association between the percentage of senescent cells and microbiome composition in human endometrium? Summary answer We found that cellular senescence is negatively associated with relative abundance certain bacterial taxa. What known already Recent studies indicated endometrial characteristics levels are essential for establishment normal receptivity successful embryo implantation. The secretion senescence-associated secretory phenotype (SASP) components...
Abstract Study question We aimed to compare the endometrial microbiome between pregnant and non-pregnant women after frozen embryo transfer (FET) with euploid embryos. Summary answer Specific bacteria taxa had significantly higher relative abundance in endometrium of patients implantation failure FET What is known already Several studies revealed a significant association composition, including Lactobacilli pathogen species occurrence or miscarriage. However, there still scarce information...
Abstract Study question Is there an association between the endometrial microbiome and local immune cell composition during mid-secretory phase? Summary answer The percentage of neutrophils was negatively related to highest number microorganisms, while B-cells T-helpers were positively certain bacterial taxa. What is known already Endometrial receptivity strongly influenced by its inflammatory status. Meanwhile, many studies on impact are arising. Knowing that has effect system, it worth...
Abstract The most common primary cardiac tumors are myxomas, while hamartomas rare. Cardiac may constitute manifestation of a genetic disorder such as tuberous sclerosis, or could be diagnosed independently solitary lesion. We present two rare cases detected via diagnostic imaging and subsequent histopathology examination. first described case is that male preterm foetus with multiple rhabdomyomas in the heart, discovered during foetal echocardiography. finding was later confirmed by...
Abstract Study question Does advancing male age influence the frequency of occurrence sperm abnormalities? Summary answer Advancing was associated with increased incidence certain head and tail defects – elongated head, nuclear vacuoles, coiled tail. What is known already Evaluation reproductive potential based mainly on motility morphology. Morphological features serve as a reliable indicator in predicting fertilizing capacity sperm. Nowadays, there are various selection techniques However,...
Abstract Study question Are endometrial stem cells associated with immune cell populations during the window of implantation? Summary answer Endometrial are presence macrophages and B-cells, but do not correlate to T-cells natural killer (NK) cells. What is known already The essential for periodic uterine regeneration. Besides their role in tissue remodeling it has been recently shown that they exert immunomodulatory anti-inflammatory effect on components system. A well fact composition...
Abstract Study question Is there a relationship between the percentage of stem cells in human endometrial stroma during mid-luteal phase menstrual cycle and implantation success? Summary answer Women with successful have significantly higher stromal CD117-positive cycle. What is known already Human endometrium as highly regenerative dynamic tissue has population certain types adult localized epithelium. These cells, including mesenchymal hematopoietic participate immense cellular turnover...
Abstract Study question Is the percentage of endometrial stem cells linked to serum progesterone, estradiol, and their receptors expression in human endometrium during mid-luteal phase? Summary answer We found an association between CD117+ as well with endometrium. What is known already Various types including NOTCH1+ stromal have been Their quantities hypothesised fluctuate menstrual cycle a link receptivity. It has established that progesterone estradiol play crucial role preparation for...