A5051014889- Quantum Mechanics and Applications
- Photoreceptor and optogenetics research
- Neural dynamics and brain function
- Quantum Information and Cryptography
- Neuroscience and Neuropharmacology Research
- Microtubule and mitosis dynamics
- Biofield Effects and Biophysics
- Quantum Computing Algorithms and Architecture
- Ion channel regulation and function
- Functional Brain Connectivity Studies
- Spectroscopy and Quantum Chemical Studies
- Cellular transport and secretion
- Design Education and Practice
- Creativity in Education and Neuroscience
- Receptor Mechanisms and Signaling
- Neurogenesis and neuroplasticity mechanisms
- Paranormal Experiences and Beliefs
- Photosynthetic Processes and Mechanisms
- Advanced Thermodynamics and Statistical Mechanics
- EEG and Brain-Computer Interfaces
- Fractal and DNA sequence analysis
- Nonlinear Dynamics and Pattern Formation
- Plant and Biological Electrophysiology Studies
- Molecular spectroscopy and chirality
- Nerve injury and regeneration
University of California, Los Angeles
2024
Centre for Advanced Study
2018-2023
Tokuda Hospital
2023
University of West Bohemia
2014-2018
Kanazawa University
2006-2016
University of Pittsburgh
2012-2015
Bristol-Myers Squibb (Japan)
2013
University of Washington
2008-2010
Medical University of Varna
2002-2004
Objective In schizophrenia, alterations within the prefrontal cortical GABA system appear to be most prominent in neurons that contain parvalbumin or somatostatin but not calretinin. The transcription factors Lhx6 and Sox6 play critical roles specification, migration, maturation of neurons, calretinin continue strongly expressed this cell type-specific manner cortex adult humans. authors investigated whether and/or mRNA levels are deficient which may contribute disturbances neurons. Method...
Human creativity generates novel ideas to solve real-world problems. This thereby grants us the power transform surrounding world and extend our human attributes beyond what is currently possible. Creative are not just new unexpected, but also successful in providing solutions that useful, efficient valuable. Thus, optimizes use of available resources increases wealth. The origin creativity, however, poorly understood, semantic measures could predict success generated unknown. Here, we...
Bexarotene-activated retinoid X receptors (RXRs) ameliorate memory deficits in Alzheimer9s disease mouse models, including mice expressing human apolipoprotein E (APOE) isoforms. The goal of this study was to gain further insight into molecular mechanisms whereby ligand-activated RXR can affect or restore cognitive functions. We used an unbiased approach discover genome-wide changes cistrome (ChIP-Seq) and gene expression profile (RNA-Seq) response bexarotene the cortex APOE4 mice....
Objective In schizophrenia, alterations in markers of cortical GABA neurotransmission are prominent parvalbumin-containing neurons. Parvalbumin neurons selectively express KCNS3, the gene encoding Kv9.3 potassium channel α-subunit. subunits present voltage-gated channels that contribute to precise detection coincident excitatory synaptic inputs parvalbumin This distinctive feature appears important for synchronization neural networks γ-oscillations. Because impaired prefrontal γ-oscillations...
We commence this review by outlining the challenges faced physical theories of consciousness and briefly describe two main approaches based on classical or quantum mechanics. Next, we provide a detailed exposition motivation, theoretical construction experimental falsification celebrated model due to Beck Eccles concerning mind-brain interaction purported operate at sites neurotransmitter release in brain. Finally, propose our own vibrationally assisted tunneling mechanism involving Davydov...
The cognitive deficits of schizophrenia appear to be associated with altered cortical GABA neurotransmission in the subsets inhibitory neurons that express either parvalbumin (PV) or somatostatin (SST). Identification molecular mechanisms operate selectively these is essential for developing targeted therapeutic strategies do not influence other cell types. Consequently, we sought identify, human cortex, gene products are expressed by PV and/or SST neurons, and might contribute their...
Feynman's sum-over-histories formulation of quantum mechanics has been considered a useful calculational tool in which virtual Feynman histories entering into coherent superposition cannot be individually measured. Here we show that sequential weak values, inferred by consecutive measurements projectors, allow direct experimental probing individual histories, thereby revealing the exact nature interference coherently superposed histories. Because total sum values multitime projection...
In the cortex of subjects with schizophrenia, expression glutamic acid decarboxylase 67 (GAD67), enzyme primarily responsible for cortical GABA synthesis, is reduced in subset neurons that express parvalbumin (PV). This GAD67 deficit accompanied by lower levels other GABA-associated transcripts, including transporter-1, PV, brain-derived neurotrophic factor (BDNF), tropomyosin receptor kinase B, somatostatin, GABAA α1 subunit, and KCNS3 potassium channel subunit mRNAs. contrast, messenger...
Abstract We have attempted to elucidate mechanisms underlying differential vulnerability glutamate (Glu) using cultured neurons prepared from discrete structures of embryonic rat brains. Brief exposure Glu led a significant decrease in the mitochondrial activity hippocampal for 9 or 12 days at 10 μM 1 mM with an apoptosis‐like profile, without markedly affecting that cortical neurons. also increased lactate dehydrogenase release along marked number cells immunoreactive neuronal marker...
Entanglement measures quantify the amount of quantum entanglement that is contained in states. Typically, different do not have to be partially ordered. The presence a definite partial order between two for all states, however, allows meaningful conceptualization sensitivity entanglement, which will greater measure produces larger numerical values. Here, we investigated normalized versions four based on Schmidt decomposition bipartite pure namely, concurrence, tangle, robustness and number....
This paper presents in details how the subjective time is constructed by brain cortex via reading packets of information called labels, produced right basal ganglia that act as timekeeper. Psychophysiological experiments performed have measured quanta to be 40 ms and show consciousness operates beyond scale - an important result having profound implications for Q-mind theory. Although most current mainstream biophysics research on cognitive processes, modelled a neural network obeying...
Abstract Neural progenitor cell is a generic term for undifferentiated populations composed of neural stem, neuronal progenitor, and glial cells with abilities self‐renewal multipotentiality. In this study, we have attempted to evaluate the possible functional expression N‐methyl‐D‐aspartate (NMDA) receptors by prepared from neocortex 18‐day‐old embryonic rats. Cells were cultured in presence basic fibroblast growth factor (bFGF) different periods up 12 days under floating conditions....