A5032998791- RNA Research and Splicing
- Iron Metabolism and Disorders
- Developmental Biology and Gene Regulation
- RNA and protein synthesis mechanisms
- Trace Elements in Health
- RNA modifications and cancer
- Reproductive Biology and Fertility
- Chronic Myeloid Leukemia Treatments
- Signaling Pathways in Disease
- Hemoglobinopathies and Related Disorders
- Genomics and Chromatin Dynamics
- Alzheimer's disease research and treatments
- RNA Interference and Gene Delivery
- Protein Kinase Regulation and GTPase Signaling
- Genetics and Neurodevelopmental Disorders
- Chromosomal and Genetic Variations
- Neurogenesis and neuroplasticity mechanisms
- Neurobiology and Insect Physiology Research
- Genetic and phenotypic traits in livestock
- Microtubule and mitosis dynamics
- Epigenetics and DNA Methylation
- Plant Molecular Biology Research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
University of Zurich
2017
Princeton University
1999-2007
Howard Hughes Medical Institute
1999-2007
European Molecular Biology Laboratory
1999-2000
Baylor College of Medicine
1999
European Bioinformatics Institute
1998
Yale University
1997
Saarland University
1993-1995
The Gurdon Institute
1995
Wellcome Trust
1995
Amanda Norvell, Richard L. Kelley, Kristina Wehr, and Trudi Schüpbach Howard Hughes Medical Insitute, Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544 USA; Cell Baylor College Medicine, Houston, Texas 77030 USA
Abstract Drosophila females are larger than males. In this article, we describe how X-chromosome dosage drives sexual dimorphism of body size... size through two means: first, unbalanced expression a key X-linked growth-regulating gene, and second, female-specific activation the sex-determination pathway. determines phenotypic sex by regulating genes sex-determining presence sets signal elements (XSEs), Sex-lethal (Sxl) is activated in female (XX) but not male (XY) animals. Sxl activates...
Iron regulatory protein 1 (IRP-1) binding to an iron-responsive element (IRE) located close the cap structure of mRNAs represses translation by precluding recruitment small ribosomal subunit these mRNAs. This mechanism is position dependent; reporter bearing IREs further downstream exhibit diminished translational control in transfected mammalian cells. To investigate underlying mechanism, we have recapitulated this effect a rabbit reticulocyte cell-free system. We show that 43S...
Conference Article| August 01 1998 Molecular Cloning and Characterisation of a Novel Duodenal-Specific Gene Implicated in Iron Absorption A.T. McKIE; McKIE *Department Medicine, King's College School Medicine Dentistry, London SE5 9NU Search for other works by this author on: This Site PubMed Google Scholar K. WEHR; WEHR ΨE.M.B.L, Meyerhofstrasse 1, D-69117, Heidelberg, Germany R.J. SIMPSON; SIMPSON ϕDepartment Clinical Biochemistry, T.J. PETERS; PETERS M.W. HENTZE; HENTZE F. FARZANEH...
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