A5013184297- Food Allergy and Anaphylaxis Research
- Immunodeficiency and Autoimmune Disorders
- Drug-Induced Adverse Reactions
- Allergic Rhinitis and Sensitization
- Pharmaceutical studies and practices
- Contact Dermatitis and Allergies
- Asthma and respiratory diseases
- Transgenic Plants and Applications
- Urticaria and Related Conditions
- Autism Spectrum Disorder Research
- Chronic Lymphocytic Leukemia Research
- Genetics and Neurodevelopmental Disorders
- Blood groups and transfusion
- Eosinophilic Esophagitis
- Ubiquitin and proteasome pathways
- Pediatric health and respiratory diseases
- Cellular Mechanics and Interactions
- Immune Cell Function and Interaction
- Acute Lymphoblastic Leukemia research
- Platelet Disorders and Treatments
- Blood disorders and treatments
- Antibiotics Pharmacokinetics and Efficacy
- Autoimmune and Inflammatory Disorders Research
- Cancer-related gene regulation
- Salivary Gland Disorders and Functions
Centre Hospitalier Universitaire Sainte-Justine
2016-2025
Université de Montréal
2016-2025
Boston Children's Hospital
2019-2023
Harvard University
2020-2023
National Cancer Institute
2023
National Institutes of Health
2023
Center for Cancer Research
2023
Boston Children's Museum
2019
Abstract Colorectal cancer is driven by mutations that activate canonical WNT/β-catenin signaling, but inhibiting WNT has significant on-target toxicity, and there are no approved therapies targeting dominant oncogenic drivers. We recently found activating a β-catenin–independent branch of signaling inhibits GSK3-dependent protein degradation induces asparaginase sensitivity in drug-resistant leukemias. To test predictions from our model, we turned to colorectal because these cancers can...
Background Prolonged (>10 days) use of intravenous (IV) piperacillin/tazobactam has been associated with a risk developing hemophagocytic lymphohistiocytosis (HLH) syndrome. However, clinical and biological descriptions this rare complication are lacking in the literature, such as management guidelines. Objectives Methods We describe series five children who presented an HLH-like hypersensitivity reaction after prolonged IV therapy between February 2024 October single pediatric...
Chronic granulomatous disease (CGD) is a rare primary immune deficiency caused by mutations in genes coding for components of the nicotinamide adenine dinucleotide phosphate oxidase, characterized severe and recurrent bacterial fungal infections, together with inflammatory complications. Dysregulation responses are often present this may lead to lesions, most affecting gastrointestinal (GI) urinary tracts. Treatment complications usually includes corticosteroids, whereas antimicrobial...
A1 Role of fibrocytes in allergic rhinitis Marie-Ève Côté, Boulay, Sophie Plante, Jamila Chakir, Louis-Philippe Boulet A2 Patterns aeroallergens sensitization Northern Alberta Hanan Ahmed, Maria-Beatriz Ospina, Kyriaki Sideri, Harissios Vliagoftis A3 Addressing acceptable risk for adolescents with Food-Induced Anaphylaxis (FIA) Sara F. Johnson, Roberta L. Woodgate A4 Outcomes matched related and unrelated bone marrow transplantation after reduced-toxicity conditioning children suffering from...
Current recommendations for the management of penicillin allergy are to perform skin testing (PST) with penicilloyl-polylysine (PPL) and benzylpenicillin (BP) prior drug challenge amoxicillin. However, role PST is increasingly questioned in pediatric setting. To resolve question PST's diagnostic accuracy, consecutive children a history non-life-threatening referred tertiary-care center were recruited undergo double-blinded PPL BP provocation Five 158 participants (3.2%) presented an...
Abstract Aim Childhood immune thrombocytopenia ( ITP ) has been associated with low bleeding rates and a high frequency of spontaneous remission. Although current guidelines suggest that most patients are just observed, children still receive platelet‐enhancing therapies for fear complications. We hypothesised standardised protocol step‐down approach would reduce hospitalisation treatment use. Method A retrospective chart review was performed on diagnosed acute between January 2010 December...
Background: Multiple animal antigens, spores and pollens were collected identified from the Kuwaiti atmosphere.The role for these antigens in mediating allergic rhinitis residents needs to be evaluated.Objective: To investigate causes (both indoors outdoors) of residents.Method: This is a retrospective study all positive skin tests that we obtained our Allergy clinic Mubarak Alkabeer Hospital Kuwait, during period between May 2013 December 2015, patients who presented with symptoms and/or...
Severe combined immunodeficiency (SCID) comprises rare inherited disorders of immunity that require definitive treatment through hematopoietic cell transplantation (HCT) or gene therapy for survival. Despite successes allogeneic HCT, many SCID patients experience incomplete immune reconstitution, persistent T-cell lymphopenia, and poor long-term outcomes.
Flexible dosing of IgPro20 (Hizentra®, CSL Behring, King Prussia, Pennsylvania) maintains normal serum immunoglobulin G (IgG) levels in patients with primary immunodeficiencies (PID). Until now, clinical trials testing the pharmacokinetic (PK) characteristics IgG weekly and biweekly subcutaneous therapy were not published. This is first study assessing PK following PID. The was conducted 2 parts: (12 weeks) (up to 12 months). Serum concentration-time data analyzed using noncompartmental...
The Food Allergy Quality of Life Questionnaire Parent Form (FAQLQ-PF) is the most widely used quality life questionnaire in food allergy. objective this study was to develop a mapping algorithm convert FAQLQ-PF scores into health state utilities.The Short-Form Six-Dimensions version 2 (SF-6Dv2) and questionnaires were collected from an academic center oral immunotherapy referral cohort. Utility estimates derived SF-6Dv2 using allergy preference set. Candidate models developed seven...