Fawzi Derrar
A5079305498- SARS-CoV-2 and COVID-19 Research
- Animal Virus Infections Studies
- COVID-19 Clinical Research Studies
- COVID-19 epidemiological studies
- SARS-CoV-2 detection and testing
- Viral Infections and Outbreaks Research
- Respiratory viral infections research
- Influenza Virus Research Studies
- Viral gastroenteritis research and epidemiology
- Pneumonia and Respiratory Infections
- Long-Term Effects of COVID-19
- Inflammatory Biomarkers in Disease Prognosis
- Plant Virus Research Studies
- Bacteriophages and microbial interactions
- Biomarkers in Disease Mechanisms
- Neuroscience of respiration and sleep
- Salmonella and Campylobacter epidemiology
- CRISPR and Genetic Engineering
- Viral Infections and Immunology Research
- Toxin Mechanisms and Immunotoxins
- vaccines and immunoinformatics approaches
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Immune responses and vaccinations
- Venomous Animal Envenomation and Studies
- Healthcare Systems and Practices
Institut Pasteur d'Algérie
2012-2025
Centre de Recherche Nucléaire d’Alger
2024
National Influenza Center
2021
Institut Pasteur
2015
Université Joseph Fourier
2015
Université Grenoble Alpes
2015
SARS-CoV-2 across Africa The impact of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has been hard to track in African countries, largely because patchy data. Wilkinson et al . curated viral genomes collected 2021 from several countries continent. Outbreaks during 2020 each country were initiated by imported cases, mostly Europe. As developed, case numbers likely many times higher than reported, and subsequent waves appear have more severe. Consequently,...
Following SARS-CoV-2 emergence in China, a specific surveillance was implemented France. Phylogenetic analysis of sequences retrieved through this suggests that detected initial introductions, involving non-clade G viruses, did not seed local transmission. Nevertheless, identification clade variants subsequently circulating the country, with earliest from patient who neither travelled to risk areas nor had contact travellers, might have been present before first recorded cases.
Abstract Following the emergence of coronavirus disease (COVID-19) in Wuhan, China December 2019, specific COVID-19 surveillance was launched France on January 10, 2020. Two weeks later, first three imported cases into Europe were diagnosed France. We sequenced 97 severe acute respiratory syndrome 2 (SARS-CoV-2) genomes from samples collected between 24 and March 24, 2020 infected patients Phylogenetic analysis identified several early independent SARS-CoV-2 introductions without local...
Abstract The progression of the SARS-CoV-2 pandemic in Africa has so far been heterogeneous and full impact is not yet well understood. Here, we describe genomic epidemiology using a dataset 8746 genomes from 33 African countries two overseas territories. We show that epidemics most were initiated by importations, predominantly Europe, which diminished following early introduction international travel restrictions. As progressed, ongoing transmission many increasing mobility led to emergence...
Abstract The immune system plays a crucial role in the response against severe acute respiratory syndrome coronavirus 2 with significant differences among patients. study investigated relationships between lymphocyte subsets, cytokines, and disease outcomes patients 2019 (COVID-19). measurements of peripheral blood lymphocytes subsets cytokine levels were performed by flow cytometry for 57 COVID-19 Patients categorized into two groups according to severity (nonsevere vs. severe). Total...
Abstract In late 2017, increased mortality was detected in chicken farms Algeria undergoing A(H9N2) influenza outbreaks. Analysis of viruses isolated from affected showed that they were monophyletic, the G1 hemagglutinin (HA) lineage, and antigenically genetically similar to contemporaneously other countries Northern Africa Middle East. The virus able spread via contact transmission between ferrets but did not cause disease intravenously inoculated chickens.
The geographic and evolutionary origins of the SARS-CoV-2 Omicron variant (BA.1), which was first detected mid-November 2021 in Southern Africa, remain unknown. We tested 13,097 COVID-19 patients sampled between mid-2021 to early 2022 from 22 African countries for BA.1 by real-time RT-PCR. By November-December 2021, had replaced Delta all sub-regions following a South-North gradient, with peak Rt 4.1. Polymerase chain reaction near-full genome sequencing data revealed genetically diverse...
SARS-CoV-2 is constantly evolving with lineages emerging and others eclipsing. Some have an important epidemiological impact are known as variants of interest (VOIs), under monitoring (VUMs) or concern (VOCs). Lineage A.27 was first defined a VUM since it holds mutations concern. Here, we report additional lineage data sequences from five African countries describe the molecular characteristics, genetic history this worldwide. Based on new investigated, most recent ancestor (tMRCA) estimated...
Influenza season 2007/2008 was marked by a worldwide emergence of oseltamivir-resistant A(H1N1) viruses possessing mutation in the neuraminidase gene causing His-to-Tyr substitution at amino acid position 275 (H275Y). These strains were isolated Algeria where 30% seasonal harbored H275Y mutation. Emergence resistant to currently approved antiviral drug determined need for susceptibility monitoring especially that oseltamivir is used hospitals some provinces country treatment influenza...
We report the activity and circulation of influenza viruses in Algeria during four seasons, from a national surveillance study carried out 2009-2010 to 2012-2013. A total 2766 samples in- outpatients, with no age restriction, were collected. The overall proportion specimens that tested positive was 46.0%. Overall, 96.6% subtyped, A/H1 subtypes accounted for 57.3% viruses. Influenza A/H3 virus cocirculated 2009-2010. In 2010-2011, high type B (66.2%) observed. subtype H3N2 identified 99%...
Background: In mid-November 2021, the SARS-CoV-2 Omicron BA.1 variant was detected in Southern Africa, prompting international travel restrictions of unclear effectiveness that exacted a substantial economic toll. Methods: Amidst wave, we tested 13,294 COVID-19 patients 24 African countries between mid-2021 to early 2022 for and Delta variants using real-time reverse transcription-PCR tests. The diagnostic precision assays evaluated by high-throughput sequencing four countries. observed...
Scorpion envenoming (SE) is a public health problem in developing countries. In Algeria, the population exposed to risk of SE was estimated at 86.45% 2019. Thus, development vaccine protect against scorpion toxins would be major advance fight this disease. This work aimed evaluate immunoprotective effect Multiple Antigenic Peptide Aah II toxin
Abstract We investigated whether dairy beef cattle raised in Algeria are Shiga toxin-producing Escherichia coli (STEC) carriers. Stx1 and stx2 genes were analysed DNA isolated from 200 faecal samples collected adult cows 27 randomly selected farms Blida, North Algeria, after amplification by PCR. Samples 61 (30.5%) animals out of the positive located 18 with a prevalence 66.7%. Interestingly, no sample any cow was for only gene, while contrast, 51 stx1 gene alone (83.6%) those 10 other both...
Abstract To explore the SARS-CoV-2 early pandemic in Algeria, a dataset comprising forty-three genomes originating from sampled Algeria and other countries worldwide, 24 December 2019 through 8 March 2020, of which, were thoroughly examined. While performing multi-component analysis regarding Algerian outbreak, toolkit phylogenetic, phylodynamic, haplotype analyses genomic effectively implemented. We estimated TMRCA reference to highlighted both introduction disease France missing data...