A5022119989- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Viral gastroenteritis research and epidemiology
- Viral Infections and Outbreaks Research
- Animal Virus Infections Studies
- Respiratory viral infections research
- COVID-19 epidemiological studies
- Influenza Virus Research Studies
- SARS-CoV-2 detection and testing
- Blood groups and transfusion
- Mosquito-borne diseases and control
- Viral Infections and Immunology Research
- Mesenchymal stem cell research
- Microbial infections and disease research
- Hepatitis B Virus Studies
- Machine Learning in Bioinformatics
- Rabies epidemiology and control
- vaccines and immunoinformatics approaches
- Genomic variations and chromosomal abnormalities
- Hepatitis Viruses Studies and Epidemiology
- Glycosylation and Glycoproteins Research
- Travel-related health issues
- Adipokines, Inflammation, and Metabolic Diseases
- Polyomavirus and related diseases
- Liver Disease Diagnosis and Treatment
Institut Pasteur du Maroc
2013-2025
Nahrain University
2017
Institut Pasteur
2012-2014
Understanding the role of humans in dispersal predominately animal pathogens is essential for their control. We used newly developed Bayesian phylogeographic methods to unravel dynamics and determinants spread dog rabies virus (RABV) North Africa. Each countries studied exhibited largely disconnected spatial with major geo-political boundaries acting as barriers gene flow. Road distances proved be better predictors movement RABV than accessibility or raw geographical distance, occasional...
The definitive diagnosis of lyssavirus infection (including rabies) in animals and humans is based on laboratory confirmation. reference techniques for post-mortem rabies are still direct immunofluorescence virus isolation, but molecular techniques, such as polymerase chain reaction (PCR) methods, increasingly being used now constitute the principal tools diagnosing epidemiological analyses. However, it remains a key challenge to obtain relevant specificity sensitivity with these while...
Reclaimed wastewater is a considerable water resource in Morocco. Its agricultural reuse requires an assessment of viral contamination. The aim this study was to detect both infectious and noninfectious human adenoviruses (HAdV) enteroviruses (EV) raw treat effluent from treatment plants (WWTPs) domestic sewage Morocco.A total 22 samples were analysed. A polyethylene glycol (PEG) precipitation method used, followed by integrated cell culture-PCR (ICC-PCR) using two lines: rhabdomyosarcoma...
In total, 656 sand flies were collected in June 2008 from Louata, a locality of Sefrou province, Morocco. Testing was conducted for the presence phlebovirus by nested reverse transcriptase polymerase chain reaction and sequencing. We detected Toscana virus four pools male Phlebotomus perniciosus. This belongs to genotype B previously recognized France Spain. is first time that has been
The Middle East and North Africa (MENA) region faces a dual challenge with regard to influenza infection due severe zoonotic outbreaks episodes the circulation of Northern Hemisphere human viruses among pilgrims.The MENA Influenza Stakeholder Network (MENA-ISN) was set-up aim increasing seasonal vaccination coverage by (i) enhancing evidence-based exchanges, (ii) awareness on safety benefits vaccination. During 7th MENA-ISN meeting, representatives from 8 countries presented their...
The geographic and evolutionary origins of the SARS-CoV-2 Omicron variant (BA.1), which was first detected mid-November 2021 in Southern Africa, remain unknown. We tested 13,097 COVID-19 patients sampled between mid-2021 to early 2022 from 22 African countries for BA.1 by real-time RT-PCR. By November-December 2021, had replaced Delta all sub-regions following a South-North gradient, with peak Rt 4.1. Polymerase chain reaction near-full genome sequencing data revealed genetically diverse...
BackgroundMiddle East respiratory syndrome coronavirus (MERS-CoV) remains a major concern for global public health. Dromedaries are the source of human zoonotic infection. MERS-CoV is enzootic among dromedaries on Arabian Peninsula, Middle and in Africa. Over 70% infected found However, all known cases MERS have occurred Peninsula with none being reported Africa.AimWe aimed to investigate serological evidence infection humans living camel-herding areas Morocco provide insights whether...
Abstract Background The identification of effective prognosis biomarkers for nasopharyngeal carcinoma (NPC) is crucial to improve treatment and patient outcomes. In the present study, we have attempted evaluate correlation between pre-treatment plasmatic Epstein-Barr virus (EBV) DNA load conventional prognostic factors in Moroccan patients with NPC. Methods study was conducted on 121 histologically confirmed NPC patients, recruited from January 2017 December 2018. Circulating levels EBV were...
Objective: Adipose-Derived Stem Cells (ADSCs) are less immunogenic cells and have a heterogenic cytokine secretion profile making them better candidate for cell-based immunotherapy.Even innately or stimulated, Interleukin-6 (IL-6) Toll-like Receptor 2 (TLR2) secreted by ADSC were modulated led to different inflammatory mechanism pathways through factors secretion.These properties can be very useful in the treatment of inflammation-associated chronic diseases.To used, ex-vivo expansion is...
Since December 2019 the world has been facing outbreak of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Identification infected patients and discrimination from other respiratory infections have so far accomplished by using highly specific real-time PCRs. Here we present a rapid multiplex approach (RespiCoV), combining multiplexed PCRs MinION sequencing suitable for simultaneous screening 41 viral five bacterial agents related to tract infections, including human...
Coronavirus disease 2019 (COVID-19) is a highly contagious caused by severe acute respiratory coronavirus 2 (SARS-CoV-2). This virus capable of human-to-human transmission, and spreading rapidly round the globe, with markedly high fatality rates. Unfortunately, there are neither vaccines nor specific therapies available to combat it, developments such approaches depend on pursuing multiple avenues in biomedical science. Accordingly, this paper we highlight one avenue—nanobodies—for potential...
Here, we report the identification and coding-complete genome sequences of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains obtained from patients with COVID-19. The variants identified belong to variant concern B.1.617.2 interest B.1.617.1
Globally, the recent outbreak of Zika virus (ZIKV) in Brazil, Asia Pacific, and other countries highlighted unmet medical needs. Currently, there are neither effective vaccines nor therapeutics available to prevent or treat ZIKV infection.In this study, we aimed design an epitope-based vaccine for using silico approach predict analyze B- T-cell epitopes.The prediction most antigenic epitopes has targeted capsid envelope proteins as well non-structural NS5 NS3 immune-informatics tools...
BackgroundThe effluents of wastewater treatment plants may contain infectious human viruses representing a major public health issue.Wastewater must be analyzed for viruses' detection using easy and rapid protocol. ObjectiveTo compare between two viral concentration methods used enteric in treated effluent.Then assess the presence genomes by cell culture polymerase chain reaction (PCR). MethodsFifty samples were collected from during one year survey (January-December 2009) order to virus...
Dipeptidyl peptidase 4 (DPP4) has been identified as the main receptor of MERS-CoV facilitating its cellular entry and enhancing viral replication upon emergence this novel coronavirus. DPP4 is highly conserved among many species, but genetic variability direct binding residues to restrained tropism humans, camels bats. The occurrence natural polymorphisms in human not well characterized. Therefore, we aimed assess presence potential mutations domain (RBD) a population exposed Morocco...
ABSTRACT In this study, we report the identification of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) JN.1 variant and quasi-complete genomic sequencing four clinical samples in Morocco. Nasopharyngeal swabs were obtained from patients (one female, three males). The Illumina COVIDSeq Test was used for comprehensive analysis.
Background: In mid-November 2021, the SARS-CoV-2 Omicron BA.1 variant was detected in Southern Africa, prompting international travel restrictions of unclear effectiveness that exacted a substantial economic toll. Methods: Amidst wave, we tested 13,294 COVID-19 patients 24 African countries between mid-2021 to early 2022 for and Delta variants using real-time reverse transcription-PCR tests. The diagnostic precision assays evaluated by high-throughput sequencing four countries. observed...