A5088988722- Mosquito-borne diseases and control
- Vector-borne infectious diseases
- Viral Infections and Vectors
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Malaria Research and Control
- Vector-Borne Animal Diseases
- Yersinia bacterium, plague, ectoparasites research
- Insect and Pesticide Research
- Insect Pest Control Strategies
- Insect Resistance and Genetics
- Immune Response and Inflammation
- Insect symbiosis and bacterial influences
- SARS-CoV-2 detection and testing
- Immunotherapy and Immune Responses
- Clinical Laboratory Practices and Quality Control
- Infective Endocarditis Diagnosis and Management
- Bartonella species infections research
- Travel-related health issues
- Hepatitis C virus research
- Insect-Plant Interactions and Control
- Research on Leishmaniasis Studies
- COVID-19 epidemiological studies
- Species Distribution and Climate Change
- Cell Adhesion Molecules Research
Institut Pasteur du Maroc
2016-2025
Vector (United States)
2020
Institut Pasteur
2000-2014
Aix-Marseille Université
2013
Université des Sciences, des Techniques et des Technologies de Bamako
2013
Centre International de Recherches Médicales de Franceville
2013
Université des Sciences de la Santé
2013
Hopital Universitaire Habib Bourguiba
2013
Far Eastern State Medical University
2013
Institut de Recherche pour le Développement
2013
Abstract This study aimed to compare the epidemiology of Rickettsia felis infection and malaria in France, North Africa, sub-Saharan Africa identify a common vector. Blood specimens from 3,122 febrile patients 500 nonfebrile persons were analyzed for R. Plasmodium spp. We observed significant linear trend (p<0.0001) increasing risk infection. The risks lowest Tunisia, Algeria (1%), highest rural Senegal (15%). Co-infections with occurrences relapses or reinfections identified. demonstrates...
West Nile fever (WNF) and Rift Valley (RVF) are emerging diseases causing epidemics outside their natural range of distribution. virus (WNV) circulates widely harmlessly in the old world among birds as amplifying hosts, horses humans accidental dead-end hosts. (RVFV) re-emerges periodically Africa massive outbreaks. In Maghreb, eco-climatic entomologic conditions favourable for WNV RVFV emergence. Both viruses transmitted by mosquitoes belonging to Culex pipiens complex. We evaluated ability...
Coronavirus 2019 (COVID-19) is a global health threat. The kinetics of antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) need to be assessed, as the long-term duration these immunoglobulins remains largely controversial. aim this study was assess longitudinal dynamics anti-SARS-CoV-2 nucleocapsid (N) protein and receptor-binding domain (RBD) spike up one year in cohort 190 COVID-19 patients. Between March September 2021, we enrolled patients from two regional...
Abstract Background Mosquitoes of the Culex pipiens complex are widely distributed vectors for several arboviruses affecting humans. Consequently, their populations have long been controlled using insecticides, in response to which different resistance mechanisms selected. Moreover, ecological preferences and broad adaptability allow C. mosquitoes breed highly polluted water bodies where they exposed many residuals from anthropogenic activities. It has observed mosquito species that...
Abstract The symptoms of SARS-CoV-2 infection vary widely, ranging from asymptomatic cases to severe forms marked by acute respiratory distress syndrome, multi-organ damage, and fatalities. Studies indicate a correlation between specific genes susceptibility disease severity, particularly involving variants in linked inflammation immune responses. objective this study is investigate the association rs1800795 (− 174 G > C) rs1800797 597 A G) interleukin-6 (IL-6) promoter region infection....
Abstract A total of 370 ticks, encompassing 7 species from 4 genera, were collected during 2002–2006 domestic animals and vegetation in the Taza region northeastern Morocco. Rickettsial DNA was identified 101 ticks (27%) by sequencing PCR products fragments citrate synthase outer membrane protein genes Rickettsia spp. Seven rickettsiae spotted fever group identified, including pathogens: R. aeschlimannii Hyalomma marginatum marginatum, massiliae Rhipicephalus sanguineus, slovaca Dermacentor...
Q fever has been reported throughout the African continent. The objective of this study was to detect presence Coxiella burnetii in febrile patients from Africa.Blood samples and non-febrile six countries France were investigated retrospectively for infection by molecular assays targeting IS1111 IS30A spacers.We tested 1888 Senegal, Mali, Tunisia, Algeria, Gabon, Morocco found one male adult patient (0.3%) infected with C. Algeria positive (0.5%) Senegal. For Senegal we determined that...
Control of the mosquito vector Culex pipiens with insecticides is main way to control arboviruses that species can transmit such as West Nile virus (WNV) and Rift Valley fever (RVFV). However, its efficiency has been hampered by emergence insecticide resistance. Little known about insecticide-resistance status underlying resistance mechanisms field-collected populations Cx. in Morocco. Mosquito adults from Mohammadia city Morocco were reared immature stages. The level their susceptibility...
Abstract The mitochondrial genome (mitogenome) has proven to be important for the taxonomy, systematics, and population genetics of ticks. However, current methods generate mitogenomes can cost-prohibitive at scale. To address this issue, we developed a cost-effective approach amplify sequence whole mitogenome individual tick specimens. Using two different primer sites, generated full-length amplicons that were sequenced using Oxford Nanopore Technologies’ Mk1B sequencer. We used 85 from...
ABSTRACT A broad-range 16S rRNA gene PCR assay followed by partial sequencing of the was used for detection members family Anaplasmataceae in ticks North Africa. total 418 questing Ixodes ricinus collected Tunisia and Morocco, as well 188 Rhipicephalus from dogs 52 Hyalomma bovines Tunisia, were included this study. Of 324 adult I. ticks, 16.3% positive Ehrlichia spp., whereas only 3.4 2.8% nymphs larvae, respectively, positive. large heterogeneity observed nucleotide sequences. Partial...
Background The presence in Morocco of Argasid ticks the Ornithodoros erraticus complex, vector tick-borne relapsing fever (TBRF) North Africa, has been known since 1919, but disease is rarely diagnosed and few epidemiological data are available. Methodology/Principal Findings Between 2006 2011, we investigated rodent burrows 34 sites distributed across Morocco. We also collected small mammals 10 TBRF febrile patients Kenitra district. prevalence Borrelia infections was assessed by nested PCR...
In 2015, the mosquito Aedes albopictus was detected in Rabat, Morocco. This invasive species can be involved transmission of more than 25 arboviruses. It is known that each combination population and virus genotype leads to a specific interaction shape outcome infection. Testing vector competence local mosquitoes therefore prerequisite assess risks emergence. A field-collected strain Ae. from Morocco experimentally infected with dengue (DENV), chikungunya (CHIKV), zika (ZIKV) yellow fever...
Abstract Resident adherent peritoneal cells selectively released high amounts of interleukin-1 (IL-1) activity when treated with silica. The use anti-IL-1 antisera showed that both IL-Ια and IL-1β were present in supernatants silica-treated macrophages. In contrast, intracellular IL-1 was totally neutralized by anti- antibodies easily converted into the mature form autolysis cytoplasmic extracts. Anion exchange chromatography clearly separated two species silica- stimulated Natural further...
ABSTRACT Borrelia lusitaniae is a species within the complex burgdorferi sensu lato and infrequently isolated in Europe. In contrast, this by far most predominant North Africa Portugal. study, we analyzed genetic diversity, at several loci, of large population isolates from free-living Ixodes ricinus ticks collected Tunisia Morocco. We found moderate diversity whole genome using pulsed-field gel electrophoresis as well ospA gene sequences, compared to high level strain homogeneity small...
Abstract We found that 20.5% of patients with an unexplained fever in northwestern Morocco had tick-borne relapsing fever. Molecular detection specific for the 16S rRNA gene identified Borrelia hispanica. The noncoding intergenic spacer sequence domain showed high sensitivity and good resolution this species.
Mosquitoes of the Culex pipiens complex, competent vectors for West Nile virus (WNV) and Rift Valley fever (RVFV) are widely targeted by insecticide treatments. The intensive application chemical insecticides led to development resistance in many insects including mosquitoes. absence data on mechanisms Morocco allow us assess levels lambda-cyhalothrin frequency mutated gene L1014F kdr different forms Cx. complex from three regions Morocco. Mosquito adults were reared immature stages...
Background Cutaneous leishmaniasis (CL) is an infectious disease caused by various species of Leishmania and transmitted several sand flies. CL among the most neglected tropical diseases, it has represented a major health threat over past 20 years in Morocco. The main objectives this study were to identify relevant fly detect infection prevalent patient skin samples Taza, focus North-eastern Methodology finding A total 3672 flies collected CDC miniature light traps. Morphological...
Coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses serious global public health problems. Characterization of the immune response, particularly antibodies to SARS-CoV-2, is important for establishing vaccine strategies. The purpose this study was evaluate longitudinally kinetics anti-SARS-CoV-2 against spike protein (S1) up 3 months in a cohort 169 COVID-19 patients. We enrolled patients at two regional hospitals Casablanca, Morocco,...