A5078315935- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Malaria Research and Control
- Vector-Borne Animal Diseases
- Vector-borne infectious diseases
- Animal Disease Management and Epidemiology
- Viral Infections and Outbreaks Research
- Zoonotic diseases and public health
- COVID-19 epidemiological studies
- Virology and Viral Diseases
- Viral Infections and Immunology Research
- Burkholderia infections and melioidosis
- Infectious Encephalopathies and Encephalitis
- HIV Research and Treatment
- Viral gastroenteritis research and epidemiology
- Liver Disease and Transplantation
- French Urban and Social Studies
- Insect and Pesticide Research
- Salmonella and Campylobacter epidemiology
- Vibrio bacteria research studies
- Parvovirus B19 Infection Studies
- T-cell and Retrovirus Studies
- Dengue and Mosquito Control Research
- Stalking, Cyberstalking, and Harassment
- Animal Virus Infections Studies
NeuroDiderot
2015-2024
Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail
2015-2024
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2016-2024
École Nationale Vétérinaire d'Alfort
2015-2024
Département Santé Animale
2015-2024
Inserm
2023
Sorbonne Université
2023
Institut Pierre Louis d‘Épidémiologie et de Santé Publique
2023
Modèles Insectes de l'Immunité Innée
2023
Institut de Virologie
2011-2019
A serosurvey of 349 military working horses and 231 dogs was conducted in ten sites Morocco 2012. This survey revealed a high level exposure these animals to flaviviruses: seroprevalence rates 60% 62% were observed using competitive West Nile virus (WNV) enzyme-linked immunosorbent assay (cELISA). Seroneutralization test results showed that the majority cELISA-positive due WNV. Further assays vaccinated with DIVA (Differentiating Infected from Vaccinated Animals) indicated anti-WNV...
West Nile virus (WNV), Japanese encephalitis (JEV), and tick-borne (TBEV) are flaviviruses responsible for severe neuroinvasive infections in humans horses. The confirmation of flavivirus is mostly based on rapid serological tests such as enzyme-linked immunosorbent assays (ELISAs). These suffer from poor specificity, mainly due to antigenic cross-reactivity among members. Robust diagnosis therefore needs be validated through neutralisation (VNTs) which time-consuming require BSL3...
Background West Nile virus (WNV) and Usutu (USUV), two closely related flaviviruses, mainly follow an enzootic cycle involving mosquitoes birds, but also infect humans other mammals. Since 2010, their epidemiological situation may have shifted from irregular epidemics to endemicity in several European regions; this requires confirmation, as it could implications for risk assessment surveillance strategies. Aim To explore the seroprevalence animals potential of WNV USUV Southern France, given...
Tick-borne encephalitis virus' (TBEV) geographic range and the human incidence are increasing throughout Europe, putting a number of non-endemic regions countries at risk outbreaks. In spring 2020, there was an outbreak tick-born (TBE) in Ain, Eastern France, where virus had never been detected before. All patients but one consumed traditional unpasteurised raw goat cheese from local producer. We conducted investigation suspected farm using integrative One Health approach. Our methodology...
West Nile Fever is a zoonotic disease caused by mosquito-borne flavivirus, WNV. By its clinical sensitivity to the disease, horse useful sentinel of infection. Because virus' low-level, short-term viraemia in horses, primary tools used diagnose WNV are serological tests. Inter-laboratory proficiency tests (ILPTs) were held 2010 and 2013 evaluate diagnostic suited for European network National Reference Laboratories (NRLs) equine diseases. These ILPTs designed laboratories' methods'...
Flaviviruses have become increasingly important pathogens in Europe over the past few decades. A better understanding of spatiotemporal distribution flaviviruses France is needed to define risk areas and gain knowledge dynamics virus transmission cycles. Serum samples from 1014 wild boar 758 roe deer 16 departments (administrative units) collected 2009 2014 were screened for flavivirus antibodies using a competitive ELISA (cELISA) technique. found be positive or doubtful by cELISA then...
Since 2015, annual West Nile virus (WNV) outbreaks of varying intensities have been reported in France. Recent intensification enzootic WNV circulation was observed the South France with most horse cases detected 2015 (n = 49), 2018 13), and 2019 13). A lineage 1 strain isolated from a suffering neuro-invasive disease (WNND) during episode Camargue area. breaking point epidemiology achieved 2018, when 2 emerged Southeastern areas. This probably originated spread Northern Italy caused WNND...
Usutu virus (USUV), an African mosquito-borne flavivirus closely related to West Nile virus, was first isolated in South Africa 1959. USUV emerged Europe two decades ago, causing notably massive mortality Eurasian blackbirds. is attracting increasing attention due its potential for emergence and rapid spread recent years. Although mainly asymptomatic or responsible mild clinical signs, recently described as being associated with neurological disorders humans such encephalitis...
Abstract Background Usutu virus (USUV) is an emerging neurotropic arthropod-borne recently involved in massive die offs of wild birds predominantly reported Europe. Although primarily asymptomatic or presenting mild clinical signs, humans infected by USUV can develop neuroinvasive pathologies (including encephalitis and meningoencephalitis). Similar to other flaviviruses, such as West Nile virus, capable reaching the central nervous system. However, neuropathogenesis still poorly understood,...
The presence of major arbovirus vector species, climate change that promotes the expansion and increase their populations, potential animal reservoirs mean vector-borne diseases represent a significant health risk for Mallorca's inhabitants. Microbiological monitoring circulating arboviruses, particularly flaviviruses causing encephalitis, was initiated using domestic horses from localities near wetlands as "sentinel" hosts. A total 291 blood samples were taken 172 between 2011 2012, paired...
The genus Flavivirus in the family Flaviviridae includes some of most important examples emerging zoonotic arboviruses that are rapidly spreading across globe. Japanese encephalitis virus (JEV), West Nile (WNV), St. Louis (SLEV) and Usutu (USUV) mosquito-borne members JEV serological group. Although infections humans asymptomatic or present with mild flu-like symptoms, clinical manifestations JEV, WNV, SLEV, USUV tick-borne (TBEV) can include severe neurological disease death. In horses,...
West Nile virus (WNV) infection is a non-contagious disease mainly transmitted by the bites of infected mosquitoes from genus Culex. The maintained in mosquito–bird–mosquito cycle, and can accidentally be to mammalian hosts. Among hosts, equines humans are most sensitive WNV develop severe meningoencephalitis. As infections zoonotic equines, fever considered public animal health concern. After silent period almost ten years, re-emerged France at periphery Camargue area during summer 2015,...
West Nile virus (WNV) and Usutu (USUV) are zoonotic arboviruses. These flaviviruses mainly maintained in the environment through an enzootic cycle involving mosquitoes birds. Horses humans incidental, dead-end hosts, but can develop severe neurological disorders. Nevertheless, there is little data regarding involvement of other mammals epidemiology these In this study, we performed a serosurvey to assess exposure viruses captive birds zoo situated south France, area described for circulation...
SUMMARY This study describes the first large-scale serosurvey on West Nile virus (WNV) conducted in equine population Pakistan. Sera were collected from 449 equids two provinces of Pakistan during 2012–2013. Equine serum samples screened using a commercial ELISA kit detecting antibodies against WNV and related flaviviruses. ELISA-positive further investigated virus-specific microneutralization tests (MNTs) to identify infections with Japanese encephalitis (JEV), tick-borne (TBEV). Anti-WNV...
Japanese encephalitis (JE) is the largest worldwide cause of infectious in humans and caused by a mosquito-borne flavivirus. JE transmission cycle involves Culex mosquitoes, pigs aquatic birds as principal vertebrate amplifying hosts. infection responsible for reproductive disorder when occurring after sexual maturity. In tropical areas, endemic majority get infected before age 6 months. However, subtropical may be maturity thus experience clinical signs, inducing economic loss. The study...
The surveillance for West Nile virus (WNV) in Catalonia (northeastern Spain) has consistently detected flaviviruses not identified as WNV. With the aim of characterizing circulating Catalonia, serum samples from birds and horses collected between 2010 2019 positive by panflavivirus competition ELISA (cELISA) were analyzed microneutralization test (MNT) against different flaviviruses. A third tested inconclusive MNT, highlighting limitations current diagnostic techniques. Our results...
Live animal trade is considered a major mode of introduction viruses from enzootic foci into disease-free areas. Due to societal and behavioural changes, some wild species may nowadays be as pet species. The diversity animals involved in international thus increasing. This could benefit pathogens that have broad host range such arboviruses. objective this study was analyze the risk posed by live imports for introduction, European Union (EU), four arboviruses affect human horses: Eastern...