A5084079120- Parasitic infections in humans and animals
- Congenital Anomalies and Fetal Surgery
- Parasitic Infections and Diagnostics
- Parasite Biology and Host Interactions
- Viral Infections and Vectors
- Sperm and Testicular Function
- Zoonotic diseases and public health
- Reproductive Biology and Fertility
- SARS-CoV-2 and COVID-19 Research
- Animal Disease Management and Epidemiology
- Climate Change, Adaptation, Migration
- Vector-borne infectious diseases
- Fire effects on ecosystems
- Rabies epidemiology and control
- Vector-Borne Animal Diseases
- Mosquito-borne diseases and control
- Travel-related health issues
- Microbial infections and disease research
- Urological Disorders and Treatments
- Viral gastroenteritis research and epidemiology
- Virology and Viral Diseases
- Xenotransplantation and immune response
- Wildlife Ecology and Conservation
- Toxoplasma gondii Research Studies
- Insects and Parasite Interactions
Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail
2014-2024
Office National de la Chasse et de la Faune Sauvage
2015-2024
Modèles Insectes de l'Immunité Innée
2007-2023
University of Salford
2013
Charles Sturt University
2013
Laboratoire de Biométrie et Biologie Evolutive
2002
Université Laval
1996
Inserm
1985-1995
Hôpital Maisonneuve-Rosemont
1995
Université de Montréal
1994-1995
Coronaviruses are closely monitored in the context of emerging diseases and, as illustrated with Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) and Middle East Syndrome-coronavirus (MERS-CoV), known to cross species barrier eventually move from wildlife humans. Knowledge diversity coronaviruses is therefore essential better understand prevent emergence events. This study explored presence four wild mammal orders France: Bats, rodents, lagomorphs, hedgehogs. Betacoronavirus...
Spike-based COVID-19 vaccines induce potent neutralizing antibodies but their efficacy against SARS-CoV-2 variants decreases. OVX033 is a recombinant protein composed of the full-length nucleocapsid (N) genetically fused to oligoDOM ® , self-assembling domain which improves antigen immunogenicity. including N as an antigenic target proposed new vaccine candidate providing broad-spectrum protection sarbecoviruses. demonstrated its ability trigger cross-reactive T cell responses and...
During 2005-2010, we investigated Echinococcus multilocularis infection within fox populations in a large area France. The parasite is much more widely distributed than hitherto thought, spreading west, with higher prevalence previously reported. also present the conurbation of Paris.
Hepatitis E virus (HEV) is a fecally and orally transmitted human pathogen of worldwide distribution. In industrial countries, HEV observed in an increasing number autochthonous cases considered to be emerging pathogen. A growing body evidence suggests that zoonotic disease, pig handlers veterinarians have been reported high-risk groups for infection. The aims the present study were establish prevalence anti-HEV wild boars France identify whether forestry workers are at higher risk Three...
Understanding the pathogenesis of SARS-CoV-2 infection is key to developing preventive and therapeutic strategies against COVID-19, in case severe illness but also when disease mild. The use appropriate experimental animal models remains central vivo exploration physiopathology antiviral strategies. This study describes intranasal ferrets hamsters with low doses low-passage clinical French isolate UCN19, describing levels, excretion, immune responses pathological patterns both species....
Abstract Background Cystic echinococcosis (CE), caused by the larval stage of Echinococcus granulosus sensu lato , is a zoonotic parasitic disease economic and public health importance worldwide, especially in Mediterranean area. Canids are main definitive hosts adult cestode contaminating environment with parasite eggs released feces. In rural peri-urban areas, risk transmission to livestock as well humans high because free-roaming behavior owned/not owned dogs. Collecting data on animal...
During epididymal transit, spermatozoa acquire new surface antigens that are involved in the acquisition of their fertilizing ability. We have previously described a 34-kDa (P34H) human sperm protein shows antigenic and functional homologies with hamster P26h. P34H is localized on acrosomal cap has been proposed to be interaction zona pellucida. The aim this study was document expression during transit along male female genital tracts. Immunohistochemical techniques were performed testes...
During epididymal transit, mammalian spermatozoa acquire new surface antigens that may participate in gamete interaction. We have previously described a 26-kDa (P26h) hamster sperm protein we propose to be involved fertilization. In this study, searched for an antigenically related the human, and found anti-P26h antiserum recognizes 34-kDa (P34H) on Western blot of human proteins. Immunostaining showed is localized acrosomal cap but not testicular gametes. The effect fertilizing ability was...
Flaviviruses have become increasingly important pathogens in Europe over the past few decades. A better understanding of spatiotemporal distribution flaviviruses France is needed to define risk areas and gain knowledge dynamics virus transmission cycles. Serum samples from 1014 wild boar 758 roe deer 16 departments (administrative units) collected 2009 2014 were screened for flavivirus antibodies using a competitive ELISA (cELISA) technique. found be positive or doubtful by cELISA then...
The interaction of spermatozoa with the zona pellucida is a critical step fertilization. Specific sperm surface proteins involved in this process can be added or modified during epididymal transit. We have previously described 34-kDa human protein (P34H) that we proposed to sperm-zona interaction. In study, Western blot analysis were performed determine level P34H present on 16 men idiopathic infertility. These levels compared amount found proven fertility. addition, binding assay was from...
The purpose of this study was to develop a standardized tool for the assessment surveillance systems on zoonoses and animal diseases. We reviewed three existing methods combined them semi-quantitative associating their strengths providing way display multilevel results. developed set 78 criteria divided into ten sections, representing functional parts system. Each criterion given score according prescription scoring guide. Three graphical outputs were generated using specific combination...
This study is a component of large research project on five major neglected zoonotic diseases (NZDs) including cystic echinococcosis and was undertaken in the Province Sidi Kacem over period four years (April 2009-March 2013).
In 2011 and 2012, liver infections caused by Echinococcus ortleppi tapeworms were diagnosed in 2 humans France. a nationwide slaughterhouse survey identified 7 E. cattle. The foci for these spatially distinct. prevalence of France may be underestimated.
This study evaluated the impact of biological and environmental factors on infection red foxes (Vulpes vulpes) by Echinococcus multilocularis in an endemic area north-east France. From January 2004 to April 2006, 127 were examined for E. their stomach contents analysed. The effect year, season, age, sex urbanisation level presence was estimated using a General Linear Model (GLM) with logit link, (i.e. logistic regression). Urbanisation only influencing factor, decreasing gradient from rural...
Human cystic echinococcosis (hydatid disease) caused by the Echinococcus granulosus tapeworm continues to be a substantial cause of morbidity and mortality in many parts world. France is still considered as endemic area, but current infestation E. intermediate hosts remains currently unknown due absence official data reporting for last 20 years. A 1-year prevalence survey was conducted 24 slaughterhouses ten departments South France. We demonstrate that parasite present at low study area (4...
To investigate echinococcosis in co-endemic regions, three polymerase chain reaction (PCR) assays based on the amplification of a fragment within NADH dehydrogenase subunit 1 (ND1) mitochondrial gene were optimized for detection Echinococcus shiquicus , granulosus G1, and multilocularis DNA derived from parasite tissue or canid fecal samples. Specificity using tissue-derived was found to be 100% except E. primers that faintly detected equinus DNA. Sensitivity between 2 10 pg. Ethanol...
Alveolar echinococcosis (AE) is a lethal disease caused by infection with the metacestode stage of helminth Echinococcus multilocularis , which develops into tumorlike mass in susceptible intermediate hosts. The growth potential this parasite directly linked to nature surrounding periparasitic immune-mediated processes.
Cystic echinococcosis (CE), caused by the tapeworm Echinococcus granulosus, is a zoonotic parasitic disease that still represents serious threat to human and animal health worldwide. The Mediterranean basin recognized as one of major hotspots CE due several factors, including presence diverse intermediate host species well socio-economic cultural conditions local communities. This study aims take closer look at epidemiological data on in area assess knowledge attitudes practices shepherds...