A5046889858- Malaria Research and Control
- Mosquito-borne diseases and control
- Parasitic infections in humans and animals
- Parasites and Host Interactions
- Child Nutrition and Water Access
- Congenital Anomalies and Fetal Surgery
- Hemoglobinopathies and Related Disorders
- Complement system in diseases
- Drug-Induced Hepatotoxicity and Protection
- Parasitic Infections and Diagnostics
- Zoonotic diseases and public health
- SARS-CoV-2 and COVID-19 Research
- Drug Transport and Resistance Mechanisms
- Travel-related health issues
- Computational Drug Discovery Methods
- Trypanosoma species research and implications
- Yersinia bacterium, plague, ectoparasites research
- COVID-19 epidemiological studies
- Vector-borne infectious diseases
- Cellular transport and secretion
- Erythrocyte Function and Pathophysiology
- Agriculture and Rural Development Research
- Viral Infections and Vectors
- HIV/AIDS drug development and treatment
- Research on Leishmaniasis Studies
Centre de Recherche Médicale et Sanitaire
2022-2025
Institut Pasteur
2014-2024
Institut Pasteur de Côte d'Ivoire
2017-2024
National Hospital Niamey
2023
Center for Global Health
2021
Institut Pasteur de Dakar
2002-2019
Institut Pasteur de Madagascar
2001-2018
Modèles Insectes de l'Immunité Innée
2018
The University of Sydney
2008-2013
Centre d’Infectiologie Christophe Mérieux of Laos
2011
Cerebral malaria, a major cause of death during malaria infection, is characterised by the sequestration infected red blood cells (IRBC) in brain microvessels. Most molecules implicated adhesion IRBC on endothelial (EC) are already described; however, structure IRBC/EC junction and impact this EC poorly understood. We analysed interaction using human microvascular monolayers co-cultured with IRBC. Our study demonstrates transfer material from to plasma membrane trogocytosis-like process,...
Background Malnutrition accounts for 45% of mortality in children under five years old, despite a global mobilization against chronic malnutrition. In Madagascar, the most recent data show that prevalence stunting old is still around 47.4%. This study aimed to identify determinants rural areas Moramanga and Morondava districts target main intervention. Methods A case-control was conducted aged from 6 59.9 months, 2014–2015. We measured height weight mothers collected on child, mother...
Abstract Objectives Neurocysticercosis (NCC) is a parasitic disease caused by the larval stage of tapeworm Taenia solium. NCC mainly occurs in Africa, Latin America and South-East Asia can cause variety clinical signs/symptoms. Although it rare Europe, should nonetheless be considered as differential diagnosis. The aim this study was to describe characteristics management patients with diagnosed treated Europe. Methods We conducted systematic search published unpublished data on Europe...
Because of its dramatic public health impact, Plasmodium falciparum resistance to chloroquine (CQ) has been documented early on. Chloroquine-resistance (CQR) emerged in the late 1950's independently South East Asia and America progressively spread over all malaria areas. CQR was reported Africa 1970's, since invaded African continent. Many questions remain about actual selection spreading process parasites, evolution ancestral mutant gene(s) during spreading. Eleven clinical isolates P. from...
Intrinsic resistance of Plasmodium falciparum is clearly a major determinant the clinical failure antimalarial drugs. However, complex interactions between host, parasite and drug obscure ability to define in vivo. The vitro susceptibility assay determines ex-vivo growth presence serial concentrations and, thus, eliminates host effects, such as metabolism immunity. Although sensitivity various antimalarials provided by test provides an important indicator intrinsic susceptibility, there are...
Artemisinin, a thapsigargin-like sesquiterpene has been shown to inhibit the Plasmodium falciparum sarco/endoplasmic reticulum calcium-ATPase PfSERCA. To collect baseline pfserca sequence information before field deployment of Artemisinin-based Combination therapies that may select mutant parasites, we conducted analysis 100 isolates from multiple sites in Africa, Asia and South America. Coding diversity was large, with 29 mutated codons, including 32 SNPs (average one SNP/115 bp), which 19...
ABSTRACT Cambodia is located in an area of resistance to multiple antimalarials and has been the first country implement systematic use artesunate-mefloquine combination as first-line treatment for Plasmodium falciparum malaria. Little known, however, about prevalence mutations within natural parasite populations, impeding rational drug policy this context. Using direct sequencing PCR products, we have analyzed sequence polymorphism dihydrofolate reductase-thymidylate synthase,...
Recent studies suggest shared pathogenic pathways during malaria and allergy. Indeed, IgE, histamine, the parasite-derived Plasmodium falciparum histamine-releasing factor translationally controlled tumor protein (PfTCTP) can be found at high levels in serum from patients experiencing malaria, but their relationship with basophil activation remains unknown. We recruited P. falciparum-infected Senegal mild (MM; n = 19) or severe (SM; 9) symptoms healthy controls (HC; 38). Levels of PfTCTP,...
Infection with Plasmodium berghei is a widely used model of murine malaria and powerful tool for reverse genetic pathogenesis studies. However, the efficacy in vitro reinvasion erythrocytes generally low, limiting ANKA-infected blood obtained from susceptible infected mouse was cultured various conditions parasitaemia measured every day to evaluate rate reinvasion. High quality culture media were rates improved by vigorous orbital shaking flask increasing density medium gelatin. Using these...
Low-income cities that are subject to high population pressure and vulnerable climate events often have a low capacity continuously deliver safe drinking water. Here we reported the results of 32-year survey on temporal dynamics water quality indicators in city Antananarivo. We analyzed long-term evolution supplied characterized interactions between climatic conditions full-scale supply system. A total 25,467 samples were collected every week at different points Samples for coliforms (TC),...
The central region of Madagascar is a vast area highlands (altitude 700–2000 m). Malaria transmission has re-established itself here since the last epidemic 1985–1990 and caused deaths 40 000 persons according to Minister Health. To combat main malaria vector in region, Anopheles funestus, annual programmes indoor house spraying DDT were carried out between December 1993 January 1998 most rural areas at altitude 1000–1500 m. A parasitological serological study was then conducted highland...
To establish a simple definition of malaria attack based on blood parasite density and other explanatory covariates, cohort study was conducted from 1993 to 1996 in the Madagascar highlands undergoing low seasonal transmission falciparum malaria. Using logistic regression, variables found be significantly related risk fever are density, age, season, year. However, contrast with studies, we no evidence clear cutoff values consistent concept "pyrogenic threshold" despite gradual increase...
Background Plague is endemic within the central highlands of Madagascar, where its main reservoir black rat, Rattus rattus. Typically this species considered susceptible to plague, rapidly dying after infection inducing spread infected fleas and, therefore, dissemination disease humans. However, persistence transmission foci in same area from year year, supposes mechanisms maintenance among which rat immune responses could play a major role. Immunity against plague and subsequent survival an...
Taenia solium cysticercosis is a parasitic meat-borne disease that highly prevalent in pigs and humans Africa, but the burden vastly underestimated due to lack of official control along pork commodity chain, which hampers long-term policies.The apparent corrected prevalences T. were investigated carcasses slaughtered retailed Antananarivo (Madagascar), thanks 12-month monitoring plan two urban abattoirs.Overall prevalence was estimated at 4.6% [4.2 - 5.0%]. The overall defined as after...