A5027911035- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- HIV-related health complications and treatments
- Toxoplasma gondii Research Studies
- Cytomegalovirus and herpesvirus research
- Animal Virus Infections Studies
- SARS-CoV-2 and COVID-19 Research
- Virus-based gene therapy research
- Primary Care and Health Outcomes
- Viral gastroenteritis research and epidemiology
- Breastfeeding Practices and Influences
- Viral Infections and Outbreaks Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Health Policy Implementation Science
- SARS-CoV-2 detection and testing
- HIV/AIDS Impact and Responses
- Hepatitis C virus research
- Migration, Health and Trauma
- Tuberculosis Research and Epidemiology
- Global Maternal and Child Health
- Machine Learning in Bioinformatics
- Community Health and Development
- Sex work and related issues
- Child and Adolescent Health
University of Ottawa
2013-2025
Montfort Hospital
2021-2025
Weatherford College
2024
Marien Ngouabi University
2023
HIV Legal Network
2014
Ottawa Hospital
2013
Ottawa Hospital Research Institute
2013
Westat (United States)
2009
Jewish General Hospital
2000-2004
McGill University
2001-2004
ABSTRACT We sequenced and phylogenetically analyzed the reverse transcriptase (RT) region of five human immunodeficiency virus type 1 isolates from treatment-naive Ethiopian émigrés to Israel. Heteroduplex mobility assays were performed confirm clade C status env genomic regions. The RT sequences showed that strains clustered with viruses, a KVEQ-specific motif silent mutations (amino acids 65, 106, 138, 161, respectively) at resistance sites was present in polymerase all studied subtype...
African, Caribbean, and Black (ACB) women are overrepresented among new HIV diagnoses due to social structural factors. This study seeks create, implement, evaluate a community-based peer-led intervention improve access prevention care for ACB in Canada. multisite, five-year project, using participatory research, implementation science evaluation frameworks, will be implemented five non-iterative phases. Phase 1: Community partner engagement; 2: Critical health racial literacy training...
The geographic and evolutionary origins of the SARS-CoV-2 Omicron variant (BA.1), which was first detected mid-November 2021 in Southern Africa, remain unknown. We tested 13,097 COVID-19 patients sampled between mid-2021 to early 2022 from 22 African countries for BA.1 by real-time RT-PCR. By November-December 2021, had replaced Delta all sub-regions following a South-North gradient, with peak Rt 4.1. Polymerase chain reaction near-full genome sequencing data revealed genetically diverse...
Introduction The MAINTAIN study is an on-going RCT comparing high-dose micronutrient and anti-oxidant supplementation versus recommended daily allowance (RDA) vitamins in slowing HIV immune deficiency progression ART-naïve people with infection. Objective We planned analysis of the first 127 participants to determine baseline prevalence serum deficiencies correlates, as well tolerance adherence interventions. Methods Participants receive eight capsules twice 1) or 2) RDA supplements for two...
Although some studies show higher antiretroviral concentrations in women compared to men, data are limited. We conducted a cross-sectional study of HIV-positive determine if protease inhibitor (PI) and non-nucleoside reverse transcriptase (NNRTI) C(min) Cmax values were significantly different than historical general population (predominantly male) averages evaluate correlates concentrations.HIV-positive with virologic suppression (viral load < 50copies/mL) on their first regimen enrolled....
A quarter of all seasonal influenza cases are caused by type B virus (IBV) that also dominates periodically. Here, we investigated a recombinant adenovirus vaccine carrying synthetic HA2 representing the consensus sequence IBV hemagglutinins. The fully protected mice from lethal challenges both genetic lineages, demonstrating its breadth protection. protection was not mediated neutralizing antibodies but robust antibody-dependent cellular cytotoxicity and cell-mediated immune responses....
The inhibition of HIV-1 replication in vitro by Immunor 28 (IM28), an analog dehydroepiandrosterone (DHEA), was monitored using the laboratory wild-type strain IIIB. Evaluation 50% inhibitory dose (IC50) revealed a decrease giving IC50 value around 22 microM. toxicity drug has been determined also, MT2 cells and PBMCs. 60 microM IM28 provoked cell viability while DHEA caused same at 75 cells. These values are 125 for PBMCs 135 DHEA. Thus, is less toxic than IM28, but higher antiviral activity.
We compared factors mediating motherhood experiences among Black nursing mothers living with HIV in two North American cities to one African city. Motherhood was measured the Being a Mother Scale, and we their predictors between continents using difference estimation within hierarchical linear modeling. Cultural beliefs congruent infant feeding guidelines social support had significant positive but differing effects on continents. Perceived stress negative impact Due considerations...
Sex workers experience elevated risks of sexual and gender-based violence (SGBV) from intimate partners, clients, community members that harms health human rights. While SGBV contributes to poorer reproductive (SRH) outcomes among sex workers, including immunodeficiency virus (HIV) vulnerabilities, stigma targeting reduces SRH service access uptake. The Congo Republic is an exemplar context address toward workers. workers’ HIV prevalence (8.1%) in double the national prevalence, yet research...
Background: In mid-November 2021, the SARS-CoV-2 Omicron BA.1 variant was detected in Southern Africa, prompting international travel restrictions of unclear effectiveness that exacted a substantial economic toll. Methods: Amidst wave, we tested 13,294 COVID-19 patients 24 African countries between mid-2021 to early 2022 for and Delta variants using real-time reverse transcription-PCR tests. The diagnostic precision assays evaluated by high-throughput sequencing four countries. observed...
The BICSTaR (BICtegravir Single Tablet Regimen) study is investigating the effectiveness and safety of bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) in people with human immunodeficiency virus (HIV) treated routine clinical practice. an ongoing, prospective, observational cohort across 14 countries. Treatment-naïve (TN) treatment-experienced (TE) HIV (≥18 years age) are being followed for 24 months. We present analysis primary endpoint (HIV-1 RNA < 50 copies/mL;...
<sec> <title>BACKGROUND</title> The COVID-19 pandemic emerged as an unprecedented challenge for healthcare systems across the world disproportionately impacting immigrant and racialized populations. Canadian African, Caribbean, Black (ACB) communities representing some of most vulnerable populations in terms their susceptibility to health risks, receipt adequate care, chances recovery. </sec> <title>OBJECTIVE</title> ACB Providers Project (CAPP 2) aims strengthen ability care providers (HCP)...
L’emergence et la transmission de souches resistantes du virus l’immunodeficience humaine (VIH), qui se traduisent par une perte significative l’efficacite traitement anti-VIH, s’imposent aujourd’hui comme un probleme sante publique dans plupart des pays Sud. A cet egard, il est urgent que l’acces aux antiretroviraux les a faibles revenus s’accompagne mise en place programmes regionaux nationaux visant ameliorer l’adhesion patients therapie, afin limiter le developpement resistances. La...
Because antiretroviral therapy (ART) is allowing people living with human immunodeficiency virus (PLWH) to survive longer, they are developing more age-related comorbidities. We evaluated the effects of age and gender on burden comorbidities among PLWH. In this retrospective real-world study, de-identified data were extracted from medical charts 2000 HIV-positive adults ART across 10 sites in Canada. The prevalence was determined 6 subgroups (<30, 30–39, 40–49, 50–59, 60–69, ≥70 years)....
Introduction: Mental health is an essential component of human well-being. Nowadays there a tendency to contrast the biological disorder with mental disorder; which hardly case because first would affect body, soma while second psyche. disorders described in different psychiatric taxonomies appear be multiple etiologies. Objective: The objective study was determine prevalence and their co-morbidities during general medical consultations at Mokassa Developmental Health Center. Method: A...
Abstract Introduction The COVID-19 pandemic emerged as an unprecedented challenge for healthcare systems across the world disproportionately impacting immigrant and racialized populations. Canadian African, Caribbean, Black (ACB) communities representing some of most vulnerable populations in terms their susceptibility to health risks, receipt adequate care, chances recovery. ACB Providers Project (CAPP 2) aims strengthen ability care providers (HCP) address this community’s related needs....