A5066808545- Malaria Research and Control
- Mosquito-borne diseases and control
- Parasites and Host Interactions
- Vector-borne infectious diseases
- Complement system in diseases
- Aquaculture disease management and microbiota
- Travel-related health issues
- Invertebrate Immune Response Mechanisms
- Drug Transport and Resistance Mechanisms
- Vibrio bacteria research studies
- Mycobacterium research and diagnosis
- Viral Infections and Vectors
- Influenza Virus Research Studies
- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Tuberculosis Research and Epidemiology
- Hepatitis Viruses Studies and Epidemiology
- Hepatitis B Virus Studies
- Digital Imaging for Blood Diseases
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Pneumonia and Respiratory Infections
- Reproductive System and Pregnancy
- Viral Infections and Outbreaks Research
- Signaling Pathways in Disease
Institut Pasteur de Dakar
2015-2024
Nanyang Technological University
2008-2014
Centre National de la Recherche Scientifique
2006
Institut de Recherche pour le Développement
2006
Hôpital Aristide Le Dantec
2006
Institut Pasteur
1994
Lymphoproliferation and gamma interferon (IFN-gamma) secretion in response to 28 overlapping 20-mer synthetic peptides covering the complete sequence of mature (295-amino-acid) 85A component major secreted, fibronectin-binding antigen 85 complex from Mycobacterium tuberculosis bovis BCG (MTAg85A) was examined by using peripheral blood mononuclear cell (PBMC) cultures healthy tuberculin- lepromin-positive volunteers patients with leprosy. Peptide recognition largely promiscuous, a variety...
Modifications of the Plasmodium falciparum-infected red blood cell (iRBC) surface have been linked to parasite-associated pathology. Such modifications enable parasite establish long-lasting chronic infection by evading antibody mediate immune recognition and splenic clearance. With exception well-demonstrated roles var-encoded PfEMP1 in virulence evasion, biological significance other variant antigens (rif stevor) is largely unknown. While RIFIN located on iRBC surface, recent studies...
In the progress towards malaria elimination, accurate diagnosis of low-density asymptomatic infections is critical. Low-density submicroscopic may act as silent reservoirs that maintain low-level residual transmission in community. Light microscopy, gold standard lacks sensitivity to detect parasitaemia. this study, presence and prevalence Plasmodium carriage were investigated estimate parasites reservoir among individuals living low areas Dielmo Ndiop, Senegal during dry season.A total...
Control efforts towards malaria due to Plasmodium falciparum significantly decreased the incidence of disease in many endemic countries including Senegal. Surprisingly, Kedougou (southeastern Senegal) P. remains highly prevalent and relative contribution other species global burden is very poorly documented, partly low sensitivity routine diagnostic tools. Molecular methods offer better estimate circulating a given area. A molecular survey was carried out document parasites region.A total...
Dramatic changes in transmission intensity can impact Plasmodium population diversity. Using samples from 2 distant time-points the Dielmo/Ndiop longitudinal cohorts Senegal, we applied a molecular barcode tool to detect parasite genotypes and complexity of infection that corresponded intensity. We observed striking statistically significant difference genetic diversity between populations. Furthermore, identified genotype Dielmo Ndiop previously Thiès, potentially implicating imported...
Numerous studies elucidated the kinetics of humoral immune response post-SARS-CoV-2 infection. However, in sub-Saharan Africa, evolution SARS-CoV-2 IgG antibody responses and their interaction with pre-existing seasonal human coronavirus (HCoVs: OC43, 229E, NL63, HKU1) immunity remain underexplored. A prospective cohort study was conducted Senegal during first year COVID-19 pandemic (March to December 2020). total 204 patients laboratory-confirmed were included. Patients classified as...
Artemisinin, a thapsigargin-like sesquiterpene has been shown to inhibit the Plasmodium falciparum sarco/endoplasmic reticulum calcium-ATPase PfSERCA. To collect baseline pfserca sequence information before field deployment of Artemisinin-based Combination therapies that may select mutant parasites, we conducted analysis 100 isolates from multiple sites in Africa, Asia and South America. Coding diversity was large, with 29 mutated codons, including 32 SNPs (average one SNP/115 bp), which 19...
Malaria parasite strains have emerged to tolerate the therapeutic effects of prophylactics and drugs presently available. This resistance now poses a serious challenge researchers in bid overcome malaria parasitic infection. Recent studies shown that FK520 its analogs inhibit parasites growth by binding FK506 proteins (FKBPs) parasites. Structure based drug screening efforts on three-dimensional structural information FKBPs from Plasmodium falciparum led us identify new chemical entities...
Malaria in Senegal is due essentially to infections by Plasmodium falciparum and, a lesser extent malariae and ovale. By the use of molecular methods, detection vivax has been recently reported region Kedougou, raising question appraisal its potential prevalence this setting. A retrospective serological study was carried out using 188 samples taken from 2010 2011 longitudinal school survey during which 48 asymptomatic children (9–11 years) were recruited. Four collections collected two...
Concurrent malaria and arbovirus infections are common represent an important public health concern in regions where both diseases endemic. The present study investigates the genetic diversity complexity of Plasmodium falciparum infection concurrent malaria-arbovirus Kedougou region, southeastern Senegal. Parasite DNA was extracted from 60 to 27 sera samples collected P. isolates infected patients, respectively, followed by PCR-genotyping targeting msp-1 (block2) msp-2 (block3) allelic...
Abstract Background Ongoing efforts to fight Plasmodium falciparum malaria has reduced in many areas, but new tools are needed monitor further progress, including indicators of decreasing exposure parasite infection. Sero-surveillance is considered promising exposure, transmission and immunity. Methods IgG responses three antigen biomarkers were evaluated a retrospective study involving: (i) surveys 798 asymptomatic villagers from 2 Senegalese endemic settings conducted before 2002 after the...
Genetic analyses of the malaria parasite population and its temporal spatial dynamics could provide an assessment effectiveness disease control strategies. The genetic diversity Plasmodium falciparum has been poorly documented in Senegal, limited data are available from Kedougou Region. This study examines variation complexity P. infections acute febrile patients Kedougou, southeastern Senegal. A total 263 sera presenting with illness attending health facilities between July 2009 2013 were...
Despite significant progress in malaria control over the past twenty years, remains a leading cause of child morbidity and mortality Tropical Africa. As most patients do not consult any health facility much uncertainty persists about true burden disease range individual differences susceptibility to malaria.
FKBP35, FK506 binding protein family member, in Plasmodium species displays a canonical peptidyl-prolyl isomerase (PPIase) activity and is intricately involved the folding process. Inhibition of PfFKBP35 by or its analogues were shown to interfere with vitro growth falciparum. In this study, we have synthesized adamantyl derivatives, Supradamal (SRA/4a) SRA1/4b SRA2/4c, which demonstrate submicromolar inhibition falciparum domain 35 (FKBD35) PPIase activity. SRA not only inhibit 3D7 strain...
In the southeastern Senegal, report of Plasmodium vivax infections among febrile patients in Kedougou constitutes a new emerging health problem. Samples from 48 asymptomatic schoolchildren sampled twice year over 2 years were used to explore reservoir P. parasite this region. Both Duffy genotyping and species diagnostic assays performed. PCR detected genomic DNA 38.5% (74/192) samples. Pure falciparum identified 79.7% (59/74) 20.3% (15/74) samples, respectively. All classified as...
Malaria is a leading cause of mortality and morbidity in tropical countries, especially sub-Saharan Africa. In Senegal, control plan implemented the beginning 2000s has enabled substantial reduction due to malaria. However, eradication malaria requires vaccine that protects against Plasmodium falciparum deadliest species parasite causes this disease. characterized by an extensive genetic diversity makes development challenging. study, P. isolates was analysed from asymptomatic children...
The impact of placental malaria in African urban areas is poorly documented. We therefore conducted a study during the rainy season Dakar, an area with low transmission. Two groups delivering women were enrolled according to detection PfHRP2 blood. Ten percent positive for parasites placenta, and microscopic examination showed, respectively, 17%, 22%, 44% past, acute, chronic infection. mean birth weight decreased drastically infection placenta (2,684 ± 67 versus 3,085 66 g controls),...
Human erythrocytes are indispensable for Plasmodium falciparum development. Unlike other eukaryotic cells, there is no existing erythroid cell line capable of supporting long-term P. in vitro experiments. Consequently, invasion phenotyping experiments rely on different individuals. However, the contribution variation influencing rates remains unknown, which represents a challenge conducting large-scale comparative studies. Here, we used blood groups harboring hemoglobin genotypes to assess...
Studying the behaviour and trophic preferences of mosquitoes is an important step in understanding exposure vertebrate hosts to vector-borne diseases. In case human malaria, transmission increases when feed more on humans than other animals. Therefore, spatio-temporal dynamics vectors their feeding essential for improving vector control measures. this study, we investigated Anopheles at two sites Sudanian areas Senegal where low following implementation Blood-fed were collected monthly from...