A5003188767- Concrete Corrosion and Durability
- Dermatology and Skin Diseases
- Skin and Cellular Biology Research
- Structural Behavior of Reinforced Concrete
- Concrete and Cement Materials Research
- Advanced Measurement and Metrology Techniques
- Innovative concrete reinforcement materials
- Optical measurement and interference techniques
- Metal Alloys Wear and Properties
- Immunodeficiency and Autoimmune Disorders
- Immune Cell Function and Interaction
- Nail Diseases and Treatments
- Electron and X-Ray Spectroscopy Techniques
- Advanced Electron Microscopy Techniques and Applications
- Fire effects on concrete materials
- T-cell and B-cell Immunology
- Concrete Properties and Behavior
- Advanced Materials Characterization Techniques
- Surface Roughness and Optical Measurements
- Allergic Rhinitis and Sensitization
- Immune Response and Inflammation
- Fire Detection and Safety Systems
- Interdisciplinary Research and Collaboration
- Historical Studies on Reproduction, Gender, Health, and Societal Changes
- Metallurgy and Material Forming
Baylor College of Medicine
2023
National Institutes of Health
2016-2020
National Institute of Allergy and Infectious Diseases
2016-2020
Laboratory of Molecular Genetics
2018
University of North Dakota
2013
Lawrence Berkeley National Laboratory
2007-2011
Therapeutics Clinical Research
2006
National Institute of Standards
1981
United States Army
1981
United States Department of Commerce
1981
The underlying pathology of atopic dermatitis (AD) includes impaired skin barrier function, susceptibility to Staphylococcus aureus infection, immune dysregulation, and cutaneous dysbiosis. Our recent investigation into the potential role Gram-negative bacteria in AD revealed that isolates one particular commensal, Roseomonas mucosa, collected from healthy volunteers (HVs) improved outcomes mouse cell culture models AD. In contrast, R. mucosa patients with worsened these models. These...
Roseomonas mucosa treatment in children with atopic dermatitis is associated clinical improvements and potentially lipid-mediated TNF signaling.
Autosomal dominant hyper IgE syndrome (AD-HIES), or Job’s syndrome, is a primary immune deficiency caused by dominant-negative mutations in STAT3. Recurrent Staphylococcus aureus skin abscesses are defining feature of this syndrome. A widely held hypothesis that defects peripheral Th17 differentiation confer susceptibility has never been directly evaluated. To assess the cutaneous response AD-HIES, we induced suction blisters healthy volunteers (HVs) and patients with AD-HIES then challenged...
Keratinocytes are the most abundant cell type in epidermis. They prevent desiccation and provide immunological barrier defense against potential pathogens such as Staphylococcus aureus Candida albicans. The study of this first line immune may be hindered by invasive isolation methods and/or improper culture conditions to support stem maintenance other mechanisms contributing long-term subcultivation vitro. Primary keratinocytes have been successfully isolated from blister roofs induced...
Realizing the experimental potential of high-brightness, next generation synchrotron and free-electron laser light sources requires development reflecting x-ray optics capable wavefront preservation high-resolution nano-focusing. At Advanced Light Source (ALS) beamline 5.3.1, we are developing broadly applicable, high-accuracy, in situ, at-wavelength measurement techniques to surpass 100-nrad slope accuracy for diffraction-limited Kirkpatrick-Baez (KB) mirrors. The methodology relies on a...
Autosomal dominant hyper IgE syndrome (AD-HIES) is a primary immunodeficiency caused by loss-of-function mutation in the Signal Transducer and Activator of Transcription 3 (STAT3). This immune disorder clinically characterized increased susceptibility to cutaneous sinopulmonary infections, particular with Candida Staphylococcus aureus. It has recently been recognized that skin microbiome patients AD-HIES altered an overrepresentation certain Gram-negative bacteria Gram-positive...
Atopic diseases, particularly atopic dermatitis (AD), asthma, and allergic rhinitis (AR) share a common pathogenesis of inflammation barrier dysfunction. Epithelial to mesenchymal transition (EMT) is process where epithelial cells take on migratory phenotype essential for normal tissue repair signal through multiple inflammatory pathways. However, while links between EMT both asthma AR have been demonstrated, as we outline in this mini-review, the literature investigating AD far less...
Extract Extended abstract of a paper presented at Microscopy and Microanalysis 2007 in Ft. Lauderdale, Florida, USA, August 5 – 9,
Manganese diffusion coatings have been developed on various carbon steels by a pack-cementation process using low-cost ferromanganese cement. The microstructures of the are related to steel composition and manganizing treatment; in all cases, these consist martensitic layer directly contact with substrate superimposed γ-(FeMn) austenitic layer. For high-carbon steels, carbide layers also formed at external surface. corrosion resistance is improved when surface enriched manganese. However,...
The creep properties of organic coated and uncoated No. 6 deformed steel reinforcing bars, embedded in concrete prisms, were measured for 2 yr with corresponding tensile stresses the bars at loaded ends 15,000 psi (103 MN/m2) 30,000 (206 MN/m2). Twenty-four included tests, consisting of: 18 (in duplicates) nine different epoxy materials; two a polyvinyl chloride material; four bars. Reforcing six materials developed slip-time relationships (creep) after testing that nearly same as those...
Extended abstract of a paper presented at Microscopy and Microanalysis 2009 in Richmond, Virginia, USA, July 26 – 30,
Direct electron detectors combined with Cryo-FIB milling have made sub-nanometer resolutions possible from cellular data CryoET and subtomogram averaging.The major impediment to this technique is target localization within the cell.The iFLM module provides correlative wide-field fluorescence vacuum chamber of Aquilos 2. The resolution is, course, limited, when targeting subnanometer resolutions, a small factor entire field view final tomogram.However, it does provide sufficient accuracy...