A5027854175- Glaucoma and retinal disorders
- Ocular Surface and Contact Lens
- Corneal surgery and disorders
- TGF-β signaling in diseases
- Viral Infections and Vectors
- Immune Response and Inflammation
- Corneal Surgery and Treatments
- T-cell and B-cell Immunology
- Neurological Disorders and Treatments
- NF-κB Signaling Pathways
- Fibroblast Growth Factor Research
- Ophthalmology and Eye Disorders
- Viral Infections and Outbreaks Research
- Microbial Inactivation Methods
- Infective Endocarditis Diagnosis and Management
- S100 Proteins and Annexins
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurological Disease Mechanisms and Treatments
- Salivary Gland Disorders and Functions
- Hepatitis B Virus Studies
- Actinomycetales infections and treatment
- Vector-borne infectious diseases
- Probiotics and Fermented Foods
- Mast cells and histamine
- Polysaccharides and Plant Cell Walls
Baylor College of Medicine
2018-2022
Ocular Surface Center
2018-2022
University of Houston - Victoria
2020-2022
University of North Texas
2015-2020
University of North Texas Health Science Center
2015-2020
Smith-Kettlewell Eye Research Institute
2015-2017
The University of Texas Medical Branch at Galveston
2014-2015
Ministry of Agriculture and Rural Development
2013
Instituto Politécnico Nacional
2000
Memorial Sloan Kettering Cancer Center
1990
Characterization of the three mammalian transforming growth factor-beta (TGF-beta) isoforms, TGF-beta 1, -beta 2, and 3, indicates that 3 is somewhat more potent (ED50 = 0.5 pM versus 2 pM) than 1 as a inhibitor Mv1Lu mink lung epithelial cell line. In fetal bovine heart endothelial (FBHE) line, however, are at least 50-fold which very weak greater or equal to nM). Thus, inhibitors, resemble each other 2. The presence serum alpha 2-macroglobulin in FBHE assays decreases biological potency s,...
The eastern equine encephalitis (EEE) and Venezuelan (VEE) viruses are pathogens that infect humans horses in the Americas. Outbreaks of neurologic disease were reported Panama from May through early August 2010.
Abstract Dry eye is a common ocular inflammatory disorder characterized by tear film instability and reduced production. There increasing evidence that homeostasis of the surface impacted intestinal microbiome. We are interested in investigating potential role microbially produced small molecules mediating interaction between microbiota surface. One such molecule butyrate, short-chain fatty acid (SCFA) certain members gut through fermentation dietary fiber. Here we show SCFA transporter...
Purpose: The trabecular meshwork (TM) is involved in the outflow of aqueous humor and intraocular pressure (IOP) regulation. Regulation extracellular matrix (ECM) by TGFβ2 signaling pathways TM has been extensively studied. Recent evidence implicated toll-like receptor 4 (TLR4) regulation ECM fibrogenesis liver, kidney, lung, skin. Here, we investigated role TGFβ2–TLR4 crosstalk ocular hypertension. Methods: Cross sections human donor eyes, primary cells culture, dissected mouse rings were...
Aging is a significant risk factor for dry eye. Here we used murine aging model to investigate the effects of on antigen presenting cells (APCs) and generation pathogenic T helper (Th)-1 cells. Our results showed that APCs from aged mice accumulate at conjunctiva, have higher levels co-activation marker CD86 lower aldehyde dehydrogenase activity. Using topical ovalbumin peptide as surrogate antigen, observed an increased number antigen-loaded in draining cervical lymph nodes group loss tight...
Purpose: Transforming growth factor–β2 induces extracellular matrix (ECM) remodeling, which likely contributes to the defective function of trabecular meshwork (TM) leading glaucomatous ocular hypertension. Bone morphogenetic proteins (BMPs) inhibit these profibrotic effects TGFβ2. The BMP antagonist gremlin is elevated in TM cells and increases IOP an ex vivo perfusion culture model. purpose this study was determine whether regulates ECM TM, signals through Smad3-dependent pathway,...
Purpose: The trabecular meshwork (TM) has an important role in the regulation of aqueous humor outflow and IOP. Regulation extracellular matrix (ECM) by TGFβ2 been studied extensively. Bone morphogenetic protein (BMP) activin membrane-bound inhibitor (BAMBI) shown to inhibit or modulate signaling. We investigate BAMBI TM ECM ocular hypertension. Methods: Mouse (MTM) cells were isolated from B6;129S1-Bambitm1Jian/J flox mice, characterized for dexamethasone (DEX)–induced expression...
Dry eye disease (DED), one of the most prevalent conditions among elderly, is a chronic inflammatory disorder that disrupts tear film stability and causes ocular surface damage. Aged C57BL/6J mice spontaneously develop DED. Rapamycin potent immunosuppressant prolongs lifespan several species. Here, we compared effects daily instillation eyedrops containing rapamycin or empty micelles for three months on aged mice. Tear cytokine/chemokine profile showed pronounced increase in vascular...
As of 25 March 2015, the largest recorded outbreak Ebola virus infection is ongoing, with almost 000 cases and >10 deaths. There are 5 genetically antigenically distinct species within genus Ebolavirus. Limited cross-reactivity protection observed between these Ebolavirus species, which complicates vaccine development. However, on basis sequence homology we hypothesize that conserved epitopes present viral glycoprotein (GP), can be targeted by antibodies. In current study, a panel mouse...
Filoviruses are the causative agents of lethal hemorrhagic fever in human and non-human primates (NHP). The family Filoviridae is composed three genera, Ebolavirus, Marburgvirus Cuevavirus. There currently no approved vaccines or antiviral therapeutics for treatment filovirus infections humans. Passive transfer neutralizing antibodies targeting Ebola virus (EBOV) glycoprotein (GP) has proven effective protecting mice, guinea pigs NHP from challenges with EBOV. In this study, we generated two...
Abstract Dry eye is a common ocular inflammatory disorder characterized by tear film instability and reduced production. There increasing evidence that homeostasis of the surface impacted intestinal microbiome. We are interested in investigating potential role microbially produced small molecules mediating interaction between microbiota surface. One such molecule butyrate, short-chain fatty acid (SCFA) certain members gut through fermentation dietary fiber. Here we show SCFA transporter...