A5083568219- Pulmonary Hypertension Research and Treatments
- Immune cells in cancer
- Phagocytosis and Immune Regulation
- Cancer, Hypoxia, and Metabolism
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Air Quality and Health Impacts
- Respiratory Support and Mechanisms
- Neonatal Respiratory Health Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Blood disorders and treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Extracellular vesicles in disease
- Bacterial Infections and Vaccines
- Immunodeficiency and Autoimmune Disorders
- Erythrocyte Function and Pathophysiology
- Liver Disease Diagnosis and Treatment
- Diabetes and associated disorders
- Genomics, phytochemicals, and oxidative stress
- Vascular Anomalies and Treatments
- Legionella and Acanthamoeba research
- Eicosanoids and Hypertension Pharmacology
- Biomarkers in Disease Mechanisms
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Birth, Development, and Health
University of Chicago
2017-2024
German Center for Lung Research
2021-2022
Universities of Giessen and Marburg Lung Center
2021-2022
Justus-Liebig-Universität Gießen
2021
Pulmonary and Critical Care Associates
2020
University of Pennsylvania Health System
2013-2016
Pennsylvania Hospital
2013-2016
University of Cologne
2014
University Medical Center Freiburg
2009-2011
Background: Anti-inflammatory therapies such as IL-6 inhibition have been proposed for COVID-19 in a vacuum of evidence-based treatment. However, abrogating the inflammatory response infectious diseases may impair desired host and pre-dispose to secondary infections. Methods: We retrospectively reviewed medical record critically ill patients during an 8-week span compared prevalence infection outcomes who did not receive tocilizumab. Additionally, we included representative histopathologic...
Macrophage effector function is dynamic in nature and largely dependent on not only the type of immunological challenge but also tissue-specific environment developmental origin a given macrophage population. Recent research has highlighted importance glycolytic metabolism regulation as common feature associated with activation. Yet, most used cell lines bone marrow-derived macrophages, which do account for diversity populations role tissue specificity immunometabolism. Tissue-resident...
Tocilizumab (TCZ) has been used in the management of COVID-19-related cytokine release syndrome (CRS). Concerns exist regarding risk infections and drug-related toxicities. We sought to evaluate incidence these TCZ complications among COVID-19 patients.All adult inpatients with between 1 March 25 April 2020 that received were included. compared rate late-onset (>48 hours following admission) a control group matched according intensive care unit admission mechanical ventilation requirement....
Idiopathic pulmonary fibrosis is a fatal interstitial lung disease characterized by the TGF-β (transforming growth factor-β)–dependent differentiation of fibroblasts into myofibroblasts, which leads to excessive deposition collagen proteins and progressive scarring. We have previously shown that synthesis myofibroblasts requires de novo glycine, most abundant amino acid found in protein. upregulates expression enzymes serine–glycine pathway fibroblasts; however, transcriptional signaling...
Particulate matter (PM) air pollution causes cardiopulmonary mortality via macrophage-driven lung inflammation; however, the mechanisms are incompletely understood. RNA-sequencing demonstrated Acod1 (Aconitate decarboxylase 1) as one of top genes induced by PM in macrophages. encodes a mitochondrial enzyme that produces itaconate, which has been shown to exert anti-inflammatory effects NRF2 after LPS. Here, we demonstrate induces and reduced respiration complex II inhibition. Using Acod1-/-...
ABSTRACT Background Anti-inflammatory therapies such as IL-6 inhibition have been proposed for COVID-19 in a vacuum of evidence-based treatment. However, abrogating the inflammatory response infectious diseases may impair desired host and predispose to secondary infections. Methods We retrospectively reviewed medical record critically ill patients during an 8-week span compared prevalence infection outcomes who did not receive tocilizumab. Additionally, we included representative...
Cellular metabolism is a critical regulator of macrophage effector function. Tissue-resident alveolar macrophages (TR-AMs) inhabit unique niche marked by high oxygen and low glucose. We have recently shown that in contrast to bone marrow-derived (BMDMs), TR-AMs do not utilize glycolysis instead predominantly rely on mitochondrial function for their response. It known how changes local concentration occur during conditions such as acute respiratory distress syndrome (ARDS) might affect TR-AM...
Persistent symptoms after initial COVID-19 infection are common and frequently referred to by the umbrella terms "post-COVID syndrome" "long COVID". The sheer number of affected patients pose an increasing challenge healthcare systems worldwide. To date, our understanding pathophysiology post-COVID syndrome remains poor extent which persistent cardiopulmonary abnormalities contribute symptom complex is unclear. We sought determine presence impact sequelae in longitudinal assessment.We report...
Chronic obstructive pulmonary disease (COPD) remains a leading cause of morbidity and mortality worldwide.In this Update, we review the progress made in 2018 on mechanisms disease, clinical epidemiology, therapeutic options highlight areas for future research.
Background: Right atrial (RA) function has emerged as an important determinant of outcome in pulmonary arterial hypertension (PAH). However, studies exploring RA after initiation specific vascular treatment and its association with patients incident PAH are lacking. Methods: peak longitudinal strain (PLS), passive (PS), active contraction (PACS) were retrospectively assessed 56 treatment-naïve at baseline during follow-up monotherapy or combination therapy. Patients grouped according to...
The aim of this prospective observational study was to evaluate the efficiency a new escalating treatment strategy with vernakalant, flecainide and electrical cardioversion (EC) in patients onset atrial fibrillation (AF) after cardiac surgery. 24 AF aortic valve surgery, coronary artery bypass surgery or combined procedures were evaluated study. Additional including criteria age between 18 80, duration less than four days, body weight 100 kg no previous class I III antiarrhythmic drugs....
Resolution of lung injuries is vital to maintain gas exchange. Concurrently, there an increased risk secondary bacterial infections. Alveolar macrophages (AMs) are crucial for control pathogens and inflammation, but environmental cues that switch these functional phenotypes AMs remain elusive. Here, we discovered incapacity mount effective immune response bacteria during resolution inflammation. Mechanistically, AM efferocytosis neutrophils (PMNs), a hallmark resolution, abrogated...
ABSTRACT Particulate matter (PM) air pollution causing significant cardiopulmonary mortality via macrophage-driven lung inflammation; however, the mechanisms are not completely understood. RNA-sequencing demonstrated Acod1 ( Aconitate decarboxylase 1 ) as one of top genes induced by PM in macrophages. encodes a mitochondrial enzyme that produces itaconate, which has been shown to exert anti-inflammatory effects NRF2 after LPS. Here, we demonstrate induces and reduced respiration complex II...