A5026056095- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders Research
- Inflammasome and immune disorders
- Galectins and Cancer Biology
- Renal Diseases and Glomerulopathies
- Immunodeficiency and Autoimmune Disorders
- interferon and immune responses
- Osteomyelitis and Bone Disorders Research
- Vasculitis and related conditions
- Atherosclerosis and Cardiovascular Diseases
- T-cell and B-cell Immunology
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Liver Diseases and Immunity
- Eosinophilic Disorders and Syndromes
- Blood Coagulation and Thrombosis Mechanisms
- Platelet Disorders and Treatments
- Hematopoietic Stem Cell Transplantation
- Foreign Body Medical Cases
- Cytomegalovirus and herpesvirus research
- Infectious Diseases and Tuberculosis
- Immune Response and Inflammation
- Vitamin D Research Studies
- Airway Management and Intubation Techniques
- Complement system in diseases
- Parvovirus B19 Infection Studies
King Faisal Specialist Hospital & Research Centre
2014-2025
Alfaisal University
2022
University of Toronto
2019
Hospital for Sick Children
2019
SickKids Foundation
2019
King Saud University
2016
Esophageal foreign bodies (EFBs) are a relatively common clinical problem in pediatric patients. The majority of EFBs pass harmlessly through the gastrointestinal tract; however, some can cause significant morbidities. This study was conducted to review our experience managing esophageal patients, with an emphasis on management and outcomes complicated cases.Between March 1995 2013, records all children up age 12 years who were admitted King Khalid University Hospital, Riyadh, Saudi Arabia,...
<title>Abstract</title> Objective To achieve consensus on the definition and clinical approach of Monogenic Inflammatory Immune Dysregulation Disorders (MIIDDs), a collective term for rare conditions marked by inflammation, immune dysregulation, infection susceptibility. Methods A multi-step, evidence-based, multidisciplinary process was employed, consisting of: 1) systematic literature review across four electronic databases (Cochrane Library, Web Science, Scopus, MEDLINE via PubMed),...
Abstract Objective To report the clinical and genetic features of first cases chronic atypical neutrophilic dermatosis with lipodystrophy elevated temperature ( CANDLE ) syndrome in an Arab population to compare them patients C1q deficient systemic lupus erythematosus SLE ). Materials Methods This is a retrospective case series seen at single tertiary hospital. Medical records were reviewed for demographic data, laboratory features, histopathology imaging findings, response therapeutic...
Objective To determine the measurement properties of Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI) paediatric adaptation Skindex29 (pSkindex27) when used in childhood-onset SLE (cSLE). Methods Patients with mucocutaneous involvement cSLE were evaluated at study entry 6 months later. Besides CLASI pSkindex27, Pediatric Quality Life Inventory Generic Core scale (PedsQL-GC), its Rheumatology Module (PedsQL-RM), Activity (SLEDAI) Damage (SDI) completed. Results The...
Case ReportGenetic defects of SLC29A3 result in a wide range syndromic histiocytosis that encompasses H syndrome.Patients with variants typically have hyperpigmentation, hypertrichosis, hepatosplenomegaly, sensorineural hearing loss, diabetes mellitus, and hypogonadism.Herein, we identify novel phenotype girl presenting clinical laboratory findings similar to systemic juvenile arthritis hyperferritinemia.Exome sequencing identified homozygous variant (NM_018344.5:c.707C>T [p.T236M]).Our...
To report the differences in phenotypic characteristics, disease course, and outcome monogenic sporadic childhood lupus (SC-lupus) from a single tertiary clinic.A descriptive, observational, cross-sectional study was conducted. Data were retrospectively collected at last follow-up visit on patients with proven by genetic variants SC-lupus seen between June 1997 July 2022. selected systematic sampling presenting to our clinic; first patient chosen randomly, subsequent intervals of three....
Objective This paper points out the design, development and deployment of AutoInflammatory Disease Alliance (AIDA) International Registry dedicated to pediatric adult patients affected by Undifferentiated Systemic Diseases (USAIDs). Methods is an electronic registry employed for real-world data collection about demographics, clinical, laboratory, instrumental socioeconomic USAIDs patients. Data recruitment, based on Research Electronic Capture (REDCap) tool, designed obtain standardized...
Background and objectives: To evaluate the frequency of antiphospholipid anti-bodies (APLa) among patients with childhood lupus nephritis (cLN) to assess their impact on long-term renal outcomes. Design setting: This is an observational hospital based study. Patients methods: cLN diagnosed by biopsy seen between January 2002 June 2014 were included. APLa positivity was defined if detection positive 2 occa-sions 6-12 weeks apart during follow up. Demographic features, age at disease onset,...
Systemic lupus erythematosus (SLE) is a chronic inflammatory multisystemic disease. Monitoring disease activity thoughtout the course important for effective management and assessment of outcome.
Abstract Introduction Plasminogen (PLG) deficiency is an ultrarare disease. The reported manifestations in literature were linked to pseudomembrane formation and mucosal surfaces inflammation. Recently, PLG, its activators receptors have gained more attention inflammation regulatory processes, including the release of proinflammatory signaling molecules, thus role believed clinical implications beyond what has been known. Case Report We present a child with recurrent fever who, although...
<h3>Background</h3> Monogenic lupus is a rare, inherited entity, and the precise prevalence unknown. It demonstrates great heterogeneity in etiopathogenesis phenotypes. To date, there no standardized definition or criteria for identifying monogenic lupus. report phenotypic characteristics, identify spectrum of genetic variants related to from single tertiary clinic. <h3>Methods</h3> A descriptive, observational, cross-sectional study was conducted. Data retrospectively collected on patients...
To report the frequency of selected autoantibodies and their associations with clinical features in Arab children monogenic lupus.
Abstract Objective To evaluate the application of EULAR/ACR-2019 criteria to monogenic lupus patients and compare its performance against SLICC-2012 criteria. Methods In a multicenter retrospective cohort study, consecutive with from three tertiary clinics were enrolled. The diagnosis was based on expert physician’s opinion or fulfilling All enrolled had genetic variants. A control group sporadic childhood SLE (cSLE) non-SLE patients, included. descriptive data analysis conducted, applied...
Immunoglobulin A (IgA) vasculitis, formerly known as Henoch–Schonlein purpura, is the most common vasculitis in children affecting small-sized vessels. Although IgA a self-limiting disease, small number of patients can present with severe life-threatening complications. Here, we described pediatric patient final diagnosis complicated massive gastrointestinal bleeding and hemorrhagic shock, who recovered supportive treatment combined immunosuppressive drugs.