A5028812643- Glaucoma and retinal disorders
- Proteoglycans and glycosaminoglycans research
- CRISPR and Genetic Engineering
- Immunodeficiency and Autoimmune Disorders
- Ocular Surface and Contact Lens
- TGF-β signaling in diseases
- RNA and protein synthesis mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Medicinal plant effects and applications
- Virus-based gene therapy research
- Spine and Intervertebral Disc Pathology
- Eicosanoids and Hypertension Pharmacology
- Peroxisome Proliferator-Activated Receptors
- Advanced biosensing and bioanalysis techniques
- Platelet Disorders and Treatments
- Cancer, Hypoxia, and Metabolism
- Retinal Diseases and Treatments
- Chronic Lymphocytic Leukemia Research
- Flavonoids in Medical Research
- Cytomegalovirus and herpesvirus research
Sanofi (France)
2019-2024
Sanofi (Mexico)
2016
Institut de la Vision
2013-2016
Sorbonne Université
2013-2016
Inserm
2013-2015
Centre National de la Recherche Scientifique
2013
Loss of NBEAL2 function leads to grey platelet syndrome (GPS), a bleeding disorder characterized by macro-thrombocytopenia and α-granule-deficient platelets. A proportion patients with GPS develop autoimmunity through an unknown mechanism, which might be related the proteins interacts with, specifically in immune cells. Here we show comprehensive interactome primary T cells, based on mass spectrometry identification altogether 74 protein association partners. These include LRBA, member same...
Prostaglandin F2α analogues are the first-line medication for treatment of ocular hypertension (OHT), and prostanoid EP2 receptor agonists under clinical development this indication. The goal study was to investigate effects F (FP) activation on myofibroblast transition primary trabecular meshwork (TM) cells, which could be a causal mechanism TM dysfunction in glaucoma.Human cells were treated with either latanoprost or butaprost TGF-β2. Trabecular contraction measured three-dimensional (3D)...
<h3>Background</h3> CD40 is a cell surface receptor belonging to the tumor necrosis factor (TNFR) superfamily. broadly expressed on many immune cells, mostly by antigen-presenting cells (APCs). On APCs, it plays central role in stimulating synapses during T priming, when through its interaction with ligand CD40L licenses APCs activate antigen-specific cells. This accomplished upregulation of major histocompatibility complex molecules, increased expression costimulatory molecules CD86/CD80,...
Abstract Purpose: The role of Cbl-b as an essential modulator T cell activation has been widely documented, particularly in mouse studies. To substantiate the effects ablation human cells, gene editing conditions were optimized, and KO efficiency was evaluated along with response to stimulatory antibodies. Experimental design: Non-preactivated primary cells obtained from several donors electroporated CRISPR/Cas9-gRNA ribonucleoprotein complex targeting CBLB or controls. Cells then activated...