A5060781641- Force Microscopy Techniques and Applications
- Cardiomyopathy and Myosin Studies
- Mechanical and Optical Resonators
- Molecular Junctions and Nanostructures
- thermodynamics and calorimetric analyses
- Carbon Nanotubes in Composites
- Mitochondrial Function and Pathology
- Cellular Mechanics and Interactions
- Cardiovascular Effects of Exercise
- Electron Spin Resonance Studies
- Chemotherapy-induced cardiotoxicity and mitigation
- Nuclear Structure and Function
- Neuroscience and Neural Engineering
- Microfluidic and Bio-sensing Technologies
Université de Toulouse
2014-2022
Centre National de la Recherche Scientifique
2014-2022
Laboratoire d'Analyse et d'Architecture des Systèmes
2014-2022
University of Trieste
2021
Inserm
2014-2017
Institut des Maladies Métaboliques et Cardiovasculaires
2014-2017
Centre Hospitalier Universitaire de Toulouse
2017
Institut de Recherches en Technologies et Sciences pour le Vivant
2016
Institut des Technologies Avancées en sciences du Vivant
2014-2015
Institut Technique de l'Aviculture
2015
Abstract G protein-coupled receptors (GPCRs) form the largest family of cell surface receptors. Despite considerable insights into their pharmacology, GPCR architecture at still remains largely unexplored. Herein, we present specific unfolding different GPCRs living mammalian cells by atomic force microscopy-based single molecule spectroscopy (AFM-SMFS). Mathematical analysis distances resting state revealed presence receptor populations relying on distinct oligomeric states which are...
Single‐molecule force spectroscopy using atomic microscopy (AFM) is more and used to detect map receptors, enzymes, adhesins, or any other molecules at the surface of living cells. To be specific, this technique requires antibodies ligands covalently attached AFM tip that can specifically interact with protein interest. Unfortunately, specific are usually lacking (low affinity specificity) expensive produce (monoclonal antibodies). An alternative strategy tag interest a peptide recognized...
Clinical effects induced by arrhythmogenic cardiomyopathy (ACM) originate from a large spectrum of genetic variations, including the missense mutation lamin A/C gene (