A5082243542- Platelet Disorders and Treatments
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- Venous Thromboembolism Diagnosis and Management
- Chronic Lymphocytic Leukemia Research
- Receptor Mechanisms and Signaling
- Blood properties and coagulation
- Cardiac Ischemia and Reperfusion
- COVID-19 diagnosis using AI
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Antiplatelet Therapy and Cardiovascular Diseases
- Thermoregulation and physiological responses
- Neutropenia and Cancer Infections
- Congenital Anomalies and Fetal Surgery
- Eicosanoids and Hypertension Pharmacology
- Medical and Biological Ozone Research
- Drug-Induced Adverse Reactions
- Diagnosis and Treatment of Venous Diseases
- Renal Diseases and Glomerulopathies
- Hormonal Regulation and Hypertension
- Metabolism and Genetic Disorders
- PI3K/AKT/mTOR signaling in cancer
- Mesenchymal stem cell research
- Systemic Sclerosis and Related Diseases
Centre Hospitalier Universitaire de Toulouse
2003-2025
Inserm
2003-2025
Institut des Maladies Métaboliques et Cardiovasculaires
2021-2025
Université Toulouse III - Paul Sabatier
2007-2024
Université de Toulouse
2020-2023
Laboratoire d'Aérologie
2020-2023
Medical University of Vienna
2023
Hôpital Rangueil
2018-2021
Hôpital Laennec
1968-2015
Centre Hospitalier Universitaire de La Réunion
2009
Oxidative stress is one of the factors involved in age-related impairment cardiac function. In present study, we investigated role catecholamine-degrading enzyme monoamine oxidase (MAO) H 2 O production hearts young, adult, and old rats. MAO-dependent production, measured by a chemiluminescence-based assay, increased with age, reaching maximum 24-mo-old rats (7.5-fold increase vs. 1-mo-old rats). The following observations indicate that age-dependent generation was fully related to MAO-A...
Among the different anatomical forms of anomalous pulmonary venous return, that inferior vena cava is particular interest for following reasons: special radiological pattern which referred to as scimitar sign and associated anomalies often occur in lungs. We have successfully operated on three<sup>1</sup> patients who are reported this paper, we included a review literature.
Abstract Mild thrombocytopenia, changes in platelet gene expression, enhanced functionality, and presence of platelet-rich thrombi the lung have been associated with thromboinflammatory complications patients COVID-19. However, whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) gets internalized by platelets directly alters their behavior function infected remains elusive. Here, we investigated parameters viral material from a prospective cohort 29 COVID-19 admitted to an...
Aims Fluid retention is a phenomenon associated with taxoids. The principal objective of this study was to investigate the pathophysiological mechanism docetaxel‐induced fluid in advanced cancer patients. Methods Docetaxel administered as 1 h intravenous infusion every 3 weeks, for at least 4–6 consecutive cycles, patients breast ( n =21) or ovarian =3) carcinoma, who had received previous chemotherapy, 21 disease. Phase II clinical trials have shown that 5 day corticosteroid comedication,...
Objective. Cell death remains a major limitation of skeletal myoblast (SM) transplantation but the patterns cell survival and proliferation in heart their potential modulation by thermic stresses like heat shock (HS) cryopreservation (Cryo) are still incompletely characterized. Methods. To track SMs situ, we developed dual-marker system based on semiconservative expression foreign soluble protein, β-Galactosidase (β-Gal) constitutive Y chromosome myocardial infarction model. Control medium...
Tubular aggregate myopathy (TAM) and Stormorken syndrome (STRMK) are clinically overlapping disorders characterized by childhood-onset muscle weakness a variable occurrence of multisystemic signs, including short stature, thrombocytopenia, hyposplenism. TAM/STRMK is caused gain-of-function mutations in the Ca2+ sensor STIM1 or channel ORAI1, both which regulate homeostasis through ubiquitous store-operated entry (SOCE) mechanism. Functional experiments cells have demonstrated that induce...
Abstract Background Purinergic P2Y 1 and 12 receptors (P2Y -R -R) are G protein-coupled (GPCR) activated by adenosine diphosphate (ADP) to mediate platelet activation, thereby playing a pivotal role in hemostasis thrombosis. While is the major target of antiplatelet drugs, no antagonist has yet been developed for clinical use. However, accumulating data suggest that inhibition would ensure efficient with minimal effects on bleeding. In this context, an accurate characterization antagonists...
In November 2021, the SARS-CoV-2 Omicron variant of concern has emerged and is currently dominating COVID-19 pandemic over world. displays a number mutations, particularly in spike protein, leading to specific characteristics including higher potential for transmission. Although caused significant deaths worldwide, it generally induces less severe clinical signs compared earlier variants. As its impact on blood platelets remains unknown, we investigated platelet behavior patients infected...
Background: Several studies suggest an increased incidence of thrombosis in COVID-19 patients. However, evidence on how to prevent and even treat it is scarce. The aim this study was compare the cumulative venous thromboembolism (VTE) two different methods for lower extremity deep vein (LE-DVT) diagnosis: systematic vs. clinically guided complete compression ultrasonography (CCUS). We conducted a monocentric, prospective, open-label, non-randomized study. All consecutive patients admitted...
Vaccine-induced immune thrombotic thrombocytopenia (VITT), a recently described entity characterized by thrombosis at unusual locations such as cerebral venous sinus and splanchnic vein, has been rarely after adenoviral-encoded COVID-19 vaccines. In this study, we report the immunohistological correlates in 3 fatal cases of related to VITT analyzed an academic medical center.Detailed neuropathologic studies were performed adenoviral vaccination.Autopsy revealed extensive vein all cases....
On the basis of observation that central side effects MAO inhibitors may represent a major limit for their use in pathological processes involving peripheral MAOs, we investigated possibility generating novel able to target specifically MAOs. To address this issue, designed compounds 7-28. From biological results, 2-(5-phenyl-furan-2-yl)-4,5-dihydro-1H-imidazole (Furaline, 17) proved be suitable lead. In fact, enzyme assays on homogenate preparation from rat liver and HEK cells expressing...
Renal dopamine, synthesized by proximal tubules, plays an important role in the regulation of renal sodium excretion. Although dopaminergic system has been extensively investigated both physiological and pathological situations, mechanisms whereby dopamine is stored secreted tubule cells remain obscure. In present study we whether vesicular monoamine transporters (VMAT)-1 -2, which participate amine storing secretion, are expressed rat defined their involvement secretion. By combining...
Besides their proteome, platelets use, in all responses to the environmental cues, a huge and diverse family of hydrophobic amphipathic small molecules involved structural, metabolic signaling functions; lipids. Studying how platelet lipidome changes modulate function is an old story constantly renewed through impressive technical advances allowing discovery new lipids, functions pathways. Technical progress analytical lipidomic profiling by top-of-the-line approaches such as nuclear...
The benefits of skeletal myoblast transplantation are limited by the high rate early cell death which is partly ischemic origin. We, therefore, assessed whether graft survival could be improved additional use angiogenic cytokine erythropoietin (EPO). Thirty-five Lewis rats underwent coronary artery ligation and, two weeks later, were randomized to receive in-scar injections control medium, myoblasts (5x10(6)) or with EPO started day before and continued for (500 U/kg three times a week). A...
In the present study, we investigated existence of a back-regulation catecholamine-degrading enzyme monoamine oxidase (MAO)-A by dopamine in rat renal cells. proximal tubule cells, MAO-A expression was not modified after receptor stimulation. contrast, mesangial assay and Western blots showed that MAO activity protein increased ∼80% 48-h incubation with D 2 -like agonist bromocriptine quinpirole but 1 SKF-38393. This effect prevented -receptor antagonist sulpiride domperidone. The increase...