A5085345222- Protein Hydrolysis and Bioactive Peptides
- Advanced Proteomics Techniques and Applications
- Bladder and Urothelial Cancer Treatments
- Tissue Engineering and Regenerative Medicine
- Artificial Intelligence in Healthcare
- Chronic Kidney Disease and Diabetes
- Mass Spectrometry Techniques and Applications
- Acute Kidney Injury Research
- Peptidase Inhibition and Analysis
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Epigenetics and DNA Methylation
- Cell Adhesion Molecules Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Asthma and respiratory diseases
Mosaiques Diagnostics and Therapeutics (Germany)
2023-2024
RWTH Aachen University
2023-2024
Universitätsklinikum Aachen
2024
Background and Aims: Chronic kidney disease (CKD) significantly contributes to global morbidity mortality. Early, targeted intervention offers an ideal strategy for mitigating this burden. Peptidomic changes inform on CKD onset progression hold insights treatment strategies. We investigated the molecular effects of six different therapeutic interventions in silico all possible combinations urine peptidome, aiming identify most beneficial individual patients. Method: This study predicted...
ABSTRACT Background Before implementing individualized strategies to treat acute kidney injury (AKI), identifying clusters of patients with divergent pathophysiological mechanisms, diagnosis criteria or outcomes is the utmost importance. Here we studied sex-related molecular mechanisms in cardiac bypass (CBP) surgery developing AKI. Methods We compared characteristics 1170 referred for CBP using multivariate logistic regression and propensity score–based analysis. Performances candidate...
ABSTRACT Naturally occurring fragments of collagen type I alpha 1 chain (COL1A1) have been previously associated with chronic kidney disease (CKD), some showing positive and others negative associations. Using urinary peptidome data from healthy individuals ( n = 1131) CKD patients 5585) this aspect was investigated in detail. Based on the hypothesis that many peptides are derived not full, mature molecule, but (larger) degradation products, relationships between COL1A1 containing identical...
Abstract Previous studies have established the association of sex with gene and protein expression. This study investigated abundance endogenous urinary peptides, using capillary electrophoresis‐coupled to mass spectrometry (CE‐MS) datasets from 2008 healthy individuals patients type II diabetes, divided in one discovery two validation cohorts. Statistical analysis Mann–Whitney test, adjusted for multiple testing, revealed 143 sex‐associated peptides cohort. Of these, 90 were associated at...
Naturally occurring fragments of collagen type I alpha 1 chain (COL1A1) have been previously associated with chronic kidney disease (CKD), some showing positive and others negative associations. Using urinary peptidome data from healthy individuals (n=1131) CKD patients (n=5585) this aspect was investigated in detail. Based on the hypothesis that many peptides are derived not full, mature molecule, but (larger) degradation products, relationships between COL1A1 containing identical sequences...
Previous studies have established the association of sex with gene and protein expression. This study investigated abundance endogenous urinary peptides, using capillary electrophoresis-coupled to mass spectrometry datasets from 2008 healthy individuals patients type II diabetes, divided in one discovery two validation cohorts. Statistical analysis Mann-Whitney test, adjusted for multiple testing, revealed 143 sex-associated peptides cohort. Of these, 90 were associated at least cohorts...