Nadège Néant
A5078035422- HIV/AIDS drug development and treatment
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Pharmacological Effects and Toxicity Studies
- Intensive Care Unit Cognitive Disorders
- Pharmaceutical studies and practices
- COVID-19 and Mental Health
- HIV Research and Treatment
- Antibiotics Pharmacokinetics and Efficacy
- Prenatal Substance Exposure Effects
- Chronic Lymphocytic Leukemia Research
- Respiratory Support and Mechanisms
- Cannabis and Cannabinoid Research
- SARS-CoV-2 and COVID-19 Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Poisoning and overdose treatments
- Parvovirus B19 Infection Studies
- Biochemical and Molecular Research
- Pneumonia and Respiratory Infections
- Machine Learning in Healthcare
- Cytomegalovirus and herpesvirus research
- Pharmacogenetics and Drug Metabolism
- Venous Thromboembolism Diagnosis and Management
- Virus-based gene therapy research
- Thermal Regulation in Medicine
Hôpital de la Timone
2020-2024
Assistance Publique Hôpitaux de Marseille
2024
Inserm
2018-2023
Institut de Recherche pour le Développement
2023
All India Institute of Medical Sciences Raipur
2023
All India Institute of Medical Sciences Rishikesh
2023
Cohort (United Kingdom)
2022-2023
Centre National de la Recherche Scientifique
2019-2020
Université Paris Cité
2018-2020
Aix-Marseille Université
2018-2020
The use of prothrombin complex concentrates and the role plasma concentration anticoagulants in management bleeding patients treated with direct oral are still debated. Our aim was to describe strategies outcomes severe events anticoagulants.We performed a prospective cohort study 732 dabigatran, rivaroxaban, or apixaban hospitalized for bleeding, included prospectively registry from June 2013 November 2015.Bleeding gastrointestinal intracranial 37% (212 732) 24% (141 cases, respectively....
Abstract Little is known on the association between clinical factors and coronavirus disease 2019 (COVID‐19) more than 15 days after diagnosis. We conducted a multicentric prospective cohort of COVID‐19 hospitalized patients to describe clinical, biological, virological characteristics at hospital admission over time, according mortality up Day 60 admission. For analysis risk survival, analyses assessing associations demographic or comorbidities were performed using Cox regression model....
Abstract Background The composition of the digestive microbiota may be associated with outcome and infections in patients admitted to intensive care unit (ICU). dominance by opportunistic pathogens (such as Enterococcus ) has been death. However, whether this association remains all throughout hospitalization are lacking. Methods We performed a single-center observational prospective cohort study critically ill severe SARS-CoV-2 infection. Oropharyngeal rectal swabs were collected at...
Following a severe COVID-19 infection, proportion of individuals develop prolonged symptoms. We investigated the immunological dysfunction that underlies persistence symptoms months after resolution acute COVID-19.We analyzed cytokines, cell phenotypes, SARS-CoV-2 spike-specific and neutralizing antibodies, whole blood gene expression profiles in convalescent patients 1, 3, 6 following hospital discharge.We observed persistent abnormalities until month marked by (i) high serum levels...
Antiretroviral therapy administration is challenging in patients with HIV requiring enteral nutrition. There are limited pharmacokinetic data available regarding the absorption of crushed rilpivirine (RPV) and its impact on drug bioavailability, plasma concentrations and, consequently, efficacy treatment. We present case a 60-year-old woman diagnosed squamous cell carcinoma who needed antiretroviral following insertion gastrotomy tube September 2018. Initially, patient was treated daily dose...
The purpose of this study was to assess the antiviral activity rilpivirine/emtricitabine/tenofovir disoproxil fumarate combination and describe pharmacokinetics rilpivirine its association with resistance in clinical routine.A retrospective multicentre cohort performed both naive pretreated HIV patients receiving once-daily regimen. Immuno-virologic data, plasma trough concentrations were collected over follow-up. Statistical analyses evaluate relationship between virological response....
Abstract Background Rilpivirine is widely prescribed in people living with HIV. Although trough plasma concentrations have been associated virological response, the drug pharmacodynamics remain incompletely characterized. Objectives To develop first pharmacodynamic model of rilpivirine order to establish concentration–response relationship for future treatment optimization. Methods A retrospective observational study was conducted patients receiving once-daily rilpivirine/tenofovir...
Preclinical data support the activity of celecoxib and fluvastatin in high-grade (HGG) low-grade gliomas (LGG). A phase I trial (NCT02115074) was designed to evaluate safety this combination children with refractory/relapsed HGG LGG using four dose levels a fixed daily celecoxib. Continual Reassessment Method used for escalation. Dose-limiting toxicities (DLT) were determined on first treatment cycle. Twenty patients included. Ten ten received median 3.5 cycles. Two DLTs reported: one grade...
To describe cidofovir pharmacokinetics and assess the link between concentration safety/efficacy in children.An observational study was conducted 13 immunocompromised children receiving for adenovirus and/or cytomegalovirus infection. A population pharmacokinetic model built AUC0-24 derived each patient. Virological success defined as a decrease of viraemia by ≥1 log10 copies/mL within 15 days initiation. The association virological assessed using Wilcoxon test. An cut-off value determined...