A5008202562- Healthcare Systems and Practices
- Health, Environment, Cognitive Aging
- Sarcoma Diagnosis and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Lymphoma Diagnosis and Treatment
- Health disparities and outcomes
- Pancreatic and Hepatic Oncology Research
- Health, Medicine and Society
- Aging, Elder Care, and Social Issues
- Colorectal and Anal Carcinomas
- Ethics in Clinical Research
- Economic and Financial Impacts of Cancer
- Climate Change and Health Impacts
- Cancer Genomics and Diagnostics
- French Urban and Social Studies
- Nutritional Studies and Diet
- Gastrointestinal Tumor Research and Treatment
- Gastric Cancer Management and Outcomes
- Multiple and Secondary Primary Cancers
- Race, Genetics, and Society
- Agriculture and Rural Development Research
- Soft tissue tumors and treatment
- Colorectal Cancer Treatments and Studies
- Healthcare Systems and Reforms
- Colorectal Cancer Screening and Detection
Université Clermont Auvergne
2022-2024
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2020-2024
Territoires
2018-2024
Centre Léon Bérard
2013-2024
VetAgro Sup
2024
AgroParisTech
2024
Health Services and Performance Research Laboratory
2018-2023
Research on healthcare performance
2020-2023
Inserm
2021-2023
Université Claude Bernard Lyon 1
2018-2022
Background Since 2010, nationwide networks of reference centers for sarcomas (RREPS/NETSARC/RESOS) collected and prospectively reviewed all cases connective tumors intermediate malignancy (TIM) in France. Methods The incidence sarcoma or TIM (2013–2016) was measured using the 2013 WHO classification confirmed by a second independent review expert pathologists. Simple clinical characteristics, yearly variations correlation with published trials are presented analyzed. Results Over 150...
Abstract Background Spatial inequalities in health result from different exposures to risk factors according the features of geographical contexts, terms physical environment, social deprivation, and care accessibility. Using a common referential, which combines indices measuring these contextual features, could improve comparability studies understanding spatial dimension inequalities. Methods We developed Geographical Classification for Health (GeoClasH) distinguish French municipalities...
Contemporary research on the exposome, i.e. sum of all exposures an individual encounters throughout life and that may influence human health, bears promise integrative policy-relevant effect environment health. Critical analyses first generation exposome projects have voiced concerns over their actual breadth inclusion environmental factors a related risk molecularization public health issues. The emergence European Human Exposome Network (EHEN) provides opportunity to better situate...
Investigation of the disparities in access to experimental treatment early-phase clinical trials is lacking. The objective EGALICAN-2 study was identify factors underpinning such inequalities.A national prospective survey conducted 11 trial centers (CLIP2) certified by French National Cancer Institute. Sociodemographic, socioeconomic and medical data were collected. Univariate logistic regression models carried out estimate odds ratios 90% confidence intervals associated with effect each...
Spatial inequalities in cancer management have been evidenced by studies reporting lower quality of care or/and survival for patients living remote or socially deprived areas. NETSARC+ is a national reference network implemented to improve the outcome sarcoma France since 2010, providing access specialized diagnosis and Multidisciplinary Tumour Board (MTB). The IGéAS research program aims assess potential this innovative organization, with cancers including rare tumours, go through...
Rare cancer patients face lower survival and experience delays in diagnosis therapeutic mismanagement. Considering the specificities of rare cancers, referral networks have been implemented France to improve management patients. The IGéAS research program aims assess networks’ ability reduce inequalities. Data analysis cohort (n = 20,590, sarcoma diagnosed between 2011 2014) by gathering medical data geographical index will identify risk factors associated with belated access expertise or no...
Abstract This article provides a critical and genealogical analysis of the allostatic load research framework. AL is used as case study to analyse how current biosocial context articulated in field health inequalities research. Providing contemporary studies with genealogy concept, we show that ambition use biological tools improve measurements, predictions, ultimately public action, rooted history predates entanglements. We conceptual methodological grounding relation ambitious propositions...
The "One Health" approach underscores the connection between human, animal, and environmental health, promoting solutions to global challenges like climate change biodiversity loss. Planetary Health Diet (PHD) promotes a plant-based diet with organically grown plants reduce impact of meat production decrease risk non-communicable diseases (NCDs). BIOQUALIM project will evaluate PHD's effectiveness in preventing NCDs periodontal cancers through four inter-related studies.
Dans un contexte post-génomique, le concept d’exposome a été introduit par Christopher Wild pour proposer une approche unifiée des expositions et fédérer différents champs disciplinaires de la recherche en santé environnement. L’approche « exposomique » se caractérise volonté développer analyse à fois intégrative, longitudinale plus précise expositions, cela principalement grâce l’identification biomarqueurs. L’usage du d’exposome, qui révèle particulièrement plastique, constitue terrain...
An amendment to this paper has been published and can be accessed via the original article.
The national reference network NETSARC+ provides remote access to specialized diagnosis and the Multidisciplinary Tumour Board (MTB) improve management survival of sarcoma patients in France. IGéAS research program aims assess potential this innovative organization address geographical inequalities cancer management. Using cohort built from nationwide database, individual, clinical, determinants 3-year overall France were analyzed. analysis was focused on diagnosed 2013 (n = 2281) ensure...
Pancreatic ductal adenocarcinoma (PDAC) remains a major public health challenge, and faces disparities delays in the diagnosis access to care. Our purposes were describe medical path of PDAC patients real-life setting evaluate overall survival at 1 year. We used national hospital discharge summaries database system analyze management with newly diagnosed over year 2016 Auvergne-Rhône-Alpes region (AuRA) (France). A total 1872 met inclusion criteria corresponding an incidence 22.6 per 100,000...
Alors que les patients atteints de maladies chroniques peuvent être amenés à parcourir longues distances pour accéder aux soins, l'impact cette distance sur leur qualité vie reste assez peu évalué. Des entretiens semi-directifs ont été conduits avec 27 du Centre Léon Bérard (Lyon), en rémission cancer depuis au moins deux ans, portant leurs parcours soins et vécu la prise charge. Les rapportent, plupart, avoir bien accepté parcourir, compte tenu gravité maladie. Néanmoins, contrainte...
Aim: We performed a clinical audit of the management patients with EGFR mutations, 1 year after introduction tyrosine kinase inhibitor (EGFR-TKI) in first-line treatment. Methods: Compliance was defined by tumor molecular profiling for stage IIIB and IV non-small-cell lung cancer treatment as recommended French guidelines. Results: Among 169 EGFR-mutated patients, compliance 76.4%. The most common noncompliance criterion chemotherapy given instead EGFR-TKI. No dedicated multidisciplinary...
Background and aims: Pancreatic cancer is highly lethal often diagnosed at an advanced stage. This cohort study analyzes the impact of care pathways, delays, socio-spatial determinants on pancreatic patients’ diagnosis, treatment, prognosis. Method: Patients with adenocarcinoma newly all stages between January June 2016 in AuRA French region were included. The influence survival delays care, healthcare centers’ expertise, was evaluated. Results: Here, 538 patients included 76 centers...
Agir efficacement contre les inégalités géographiques face aux cancers implique une meilleure compréhension du processus aboutissant à ces inégalités. Une méthodologie interdisciplinaire, traitant conjointement multiples dimensions par lesquelles le territoire impacte la santé et retraçant l'évolution pronostique des patients, permettrait de répondre ce besoin. La cohorte EMS, prise en charge patients atteints sarcomes (cancers rares) Rhône-Alpes, a été analysée suivant principes...
Abstract Background Since 2010, NETSARC and RREPS collected reviewed prospectively all cases of sarcomas tumors intermediate malignancy (TIM) nationwide. Methods The nationwide incidence sarcoma or TIM (2013-2016), confirmed by expert pathologists using WHO classification are presented. Yearly variations correlation with published clinical trials was analyzed. Results 139 histological subtypes reported among the 25172 patients (n=18710, 64%) (n=6460, 36%), respectively n=5838, n=6153,...