A5049677622- Hidradenitis Suppurativa and Treatments
- Colorectal and Anal Carcinomas
- Microscopic Colitis
- Anorectal Disease Treatments and Outcomes
- Chemotherapy-related skin toxicity
- Sepsis Diagnosis and Treatment
- Inflammation biomarkers and pathways
- Influenza Virus Research Studies
- Drug-Induced Adverse Reactions
- Immune Response and Inflammation
- Autoimmune and Inflammatory Disorders
- Pneumonia and Respiratory Infections
- Urticaria and Related Conditions
- Mast cells and histamine
- Acne and Rosacea Treatments and Effects
- Pharmacogenetics and Drug Metabolism
- Wound Healing and Treatments
- Drug-Induced Hepatotoxicity and Protection
- Cancer, Hypoxia, and Metabolism
- Veterinary medicine and infectious diseases
- Pharmacological Effects and Toxicity Studies
- Myofascial pain diagnosis and treatment
- Pharmacological Effects of Natural Compounds
- Psoriasis: Treatment and Pathogenesis
- Trauma, Hemostasis, Coagulopathy, Resuscitation
National and Kapodistrian University of Athens
2014-2024
Andreas Sygros Hospital
2018-2023
University General Hospital Attikon
2009-2012
A validated tool for the dynamic severity assessment of hidradenitis suppurativa/acne inversa (HS) is lacking. To develop and validate a novel scoring system to assess HS. Delphi voting procedure was conducted among members European Hidradenitis Suppurativa Foundation (EHSF) achieve consensus towards an initial HS Severity Score System (HS4). Strengths weaknesses HS4 were examined by multicentre prospective study. Multivariate logistic regression, discriminant analysis receiver operating...
Hidradenitis suppurativa (HS) is a common skin disorder in which excessive inflammation believed to have an important role. There no specific therapy for HS.To investigate the safety and efficacy of anti-inflammatory biological anakinra HS.Double-blind, randomized, placebo-controlled clinical trial with 12-week treatment phase follow-up phase. The setting was Attikon University General Hospital, tertiary care institution Athens, Greece. Participants were 20 patients Hurley stage II or III...
Introduction There is considerable uncertainty about the reproducibility of various instruments used to measure dyspnea, their ability reflect changes in symptoms, whether they accurately patient's experience and if its evolution similar between acute heart failure syndrome patients nonacute patients.URGENT was a prospective multicenter trial designed address these issues.Methods Patients were interviewed within 1 hour first physician evaluation, emergency department or care setting, with...
Patients with moderate to severe hidradenitis suppurativa failing adalimumab therapy, or those ineligible receive it, remain a population an unmet need. Twenty patients not eligible for were randomized 12 weeks of blind treatment placebo MABp1, true human antibody targeting IL-1α. Hidradenitis clinical response score at week was the primary endpoint. The endpoint met in 10% and 60% placebo- MABp1-treated patients, respectively (odds ratio = 13.50, 95% confidence interval 1.19–152.51)....
Despite the heavy purulence observed in hidradenitis suppurativa (HS), kinetics of complement anaphylatoxins acting to prime chemotaxis neutrophils has not been studied.To explore activation HS.Circulating concentrations factor C5a, as well membrane attack complex C5b-9, were determined plasma 54 treatment-naïve patients and 14 healthy controls, pus seven patients. Results correlated with Hurley stage International Hidradenitis Suppurativa Severity Score. Peripheral blood mononuclear cells...
Background Favorable treatment outcomes with TNF blockade led us to explore cytokine responses in hidradenitis suppurativa (HS). Methods Blood monocytes of 120 patients and 24 healthy volunteers were subtyped by flow cytometry. Isolated blood mononuclear cells (PBMCs) stimulated for production; this was repeated 13 severe during etanercept. Cytokines pus measured. Results CD14brightCD16dim inflammatory patrolling increased Hurley III patients. Cytokine production PBMCs low compared controls...
The aim of this study was to investigate the kinetics immunoglobulin M (IgM) during different stages sepsis.In prospective multicenter study, blood sampling for IgM measurement done within first 24 hours from diagnosis in 332 critically ill patients; 83 patients repeated upon progression more severe stages. Among these patients, 30 with sepsis progressed into shock and monitored daily seven consecutive days. Peripheral mononuclear cells (PBMCs) were isolated 55 stimulated production.Serum...
Background The pandemic by the novel H1N1 virus has created need to study any probable effects of that infection in immune system host. Methodology/Principal Findings Blood was sampled within first two days presentation signs from 10 healthy volunteers; 18 cases flu-like syndrome; and 31 confirmed reverse RT-PCR. Absolute counts subtypes monocytes lymphocytes were determined after staining with monoclonal antibodies analysis flow cytometry. Peripheral blood mononuclear cells (PBMCs) isolated...
Recent evidence has suggested that deranged immune responses play a role in the pathogenesis of hidradenitis suppurativa (HS).To investigate single nucleotide polymorphisms (SNPs) tumour necrosis factor (TNF) and Toll-like receptor 4 (TLR4) genes physical course HS; these encode for proteins implicated response host.DNA was isolated from 190 patients with HS 84 healthy controls. SNPs at promoter regions -376G/A, -238G/A -308G/A TNF gene Asp299Gly Thr399Ile TLR4 were determined by polymerase...
BackgroundA previous randomized study showed that clarithromycin decreases the risk of death due to ventilator-associated pneumonia and shortens time until infection resolution. The efficacy was tested in a larger population with sepsis.
Introduction Until recently, biologic therapy for hidradenitis suppurativa was limited to anti-tumor necrosis factor (TNF) blockade with adalimumab (ADA). However, not all patients respond treatment ADA. This highlighted the need more therapeutic options. Interleukin (IL)-17/T-helper17 (Th17) axis may play an important role in pathophysiology of HS. Recently, IL-17A inhibitor secukinumab, which targets specifically and prevents it from interacting IL-17 receptor, has been FDA-approved
The introduction of adalimumab in the management hidradenitis suppurativa (HS) raises questions regarding cost‐efficacy treatment. To explore treatment with anti‐tumour necrosis factor (TNF) agents a real‐world cohort. Patients Hurley stage II and III HS ≥ 1 year follow‐up at least three visits per from September 2003 to December 2016 were analysed. Patient divided into two categories – for blocking TNF or other therapies. cost exacerbations was calculated based on items provided current...
<ns3:p>Hidradenitis suppurativa and psoriasis are considered chronic inflammatory diseases suggesting the existence of common pathogenetic pathways. We present two cases comorbid hidradenitis suppurativa, treated with certolizumab pegol brodalumab due to failure response other conventional therapies. Monoclonal antibody therapies have revolutionized treatment disorders such as suppurativa. Given good clinical anti-IL-17 anti-tumor necrosis factor agents in patients undergoing treatment,...
<ns3:p>Hidradenitis suppurativa and psoriasis are considered chronic inflammatory diseases suggesting the existence of common pathogenetic pathways. We present two cases comorbid hidradenitis suppurativa, treated with certolizumab pegol brodalumab due to failure response other conventional therapies. Monoclonal antibody therapies have revolutionized treatment disorders such as suppurativa. Given good clinical anti-IL-17 anti-tumor necrosis factor agents in patients undergoing treatment,...
Hidradenitis suppurativa (HS) is a chronic, inflammatory, recurrent skin disorder of the hair follicle. Trauma, mechanical pressure, or friction could have an important role in pathogenesis HS. We present patient with HS who developed new lesions shortly after cesarean section, which be explained by Koebner phenomenon. Koebnerization has recently been observed patients whom at ectopic location free from apocrine glands as result trauma. More studies need to conducted shed light on possible...
Sepsis is defined as organ failure caused by dysregulated host response to infection. While early antibiotic treatment in patients with acute infection essential, treating non-infectious must be avoided. Current guidelines recommend procalcitonin (PCT) guide discontinuation of treatment. For initiation therapy, there currently no recommended biomarker. In this study, we evaluated Host-Derived Delta-like Canonical Notch Ligand 1 (DLL1), a monocyte membrane ligand that has shown promising...