A5054812831- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Colorectal Cancer Treatments and Studies
- Cancer Immunotherapy and Biomarkers
- Cytokine Signaling Pathways and Interactions
- Respiratory Support and Mechanisms
- Genetic factors in colorectal cancer
- Colorectal and Anal Carcinomas
- Hidradenitis Suppurativa and Treatments
- Inflammasome and immune disorders
- Cancer Cells and Metastasis
- Atherosclerosis and Cardiovascular Diseases
- Proteoglycans and glycosaminoglycans research
- Microscopic Colitis
- Cell Adhesion Molecules Research
- Antimicrobial Resistance in Staphylococcus
- T-cell and Retrovirus Studies
- Glycosylation and Glycoproteins Research
- Neonatal and Maternal Infections
- IL-33, ST2, and ILC Pathways
- Cancer, Hypoxia, and Metabolism
- Monoclonal and Polyclonal Antibodies Research
- Multiple and Secondary Primary Cancers
- Biochemical and Structural Characterization
XBiotech (United States)
2011-2025
Ibero American University
2017
MannKind Corporation (United States)
2005-2008
University Hospital of Zurich
2008
Amgen (Canada)
1995-1997
Ontario Institute for Cancer Research
1995-1997
University of Toronto
1995-1997
Wellesley Institute
1997
Sunnybrook Health Science Centre
1997
Dana-Farber/Boston Children's Cancer and Blood Disorders Center
1997
In mice lacking the interleukin-2 receptor beta chain (IL-2R beta), T cells were shown to be spontaneously activated, resulting in exhaustive differentiation of B into plasma and appearance high serum concentrations immunoglobulins G1 E as well autoantibodies that cause hemolytic anemia. Marked infiltrative granulocytopoiesis was also apparent, animals died after about 12 weeks. Depletion CD4+ mutant rescued without reversion granulocyte abnormalities. did not proliferate response polyclonal...
The only causative treatment for IgE-mediated allergies is allergen-specific immunotherapy. However, fewer than 5% of allergy patients receive immunotherapy because its long duration and risk allergic side effects. We aimed at enhancing s.c. by direct administration allergen into lymph nodes. objective was to evaluate safety efficacy compared with conventional In a monocentric open-label trial, 165 grass pollen-induced rhinoconjunctivitis were randomized either 54 injections pollen extract...
Only so-called "professional" antigen-presenting cells (APCs) of hematopoietic origin are believed capable inducing T lymphocyte responses. However, fibroblasts transfected with viral proteins directly induced antiviral cytotoxic responses in vivo, without involvement host APCs. Fibroblasts only the milieu lymphoid organs. Thus, antigen localization affects self-nonself discrimination and cell-based vaccine strategies.
The leukocyte integrin LFA-1 (CD11a/CD18) plays an important role in lymphocyte recirculation and homotypic interactions. Leukocytes from mice lacking CD11a displayed defects vitro aggregation, proliferation mixed reactions, response to mitogen. Mutant mounted normal cytotoxic T cell (CTL) responses against systemic LCMV VSV infections showed ex vivo CTL function. However, LFA-1-deficient did not reject immunogenic tumors grafted into footpads demonstrate priming tumor-specific antigen. Thus...
This study evaluated whether T-cell memory reflects increased precursor frequencies of specific long-lived T cells and/or a low-level immune response against some form persistent antigen. Antivirally protective CD8+ was analyzed mostly in the original vaccinated host to assess role antigen its maintenance. mediated resistance reinfection measured spleen and peripheral solid organs with protocols that excluded protection by antibodies. In vivo compared detectable cytotoxic T-lymphocyte...
Patients with moderate to severe hidradenitis suppurativa failing adalimumab therapy, or those ineligible receive it, remain a population an unmet need. Twenty patients not eligible for were randomized 12 weeks of blind treatment placebo MABp1, true human antibody targeting IL-1α. Hidradenitis clinical response score at week was the primary endpoint. The endpoint met in 10% and 60% placebo- MABp1-treated patients, respectively (odds ratio = 13.50, 95% confidence interval 1.19–152.51)....
Research to enhance the efficiency of vaccines focuses mainly on improving either adjuvant or type and form antigen. This study evaluates influence administration route a peptide-based vaccine. Peptide are generally administered subcutaneously intradermally, from where they must reach secondary lymphatic organs induce an immune response. We analyzed efficacy peptide directly into lymph node. Using MHC class I-binding lymphocytic choriomeningitis virus, we found that intralymphatic injection...
Staphylococcus aureus can cause devastating and life-threatening infections. With the increase in multidrug resistant strains, novel therapies are needed. Limited success with active passive immunization strategies have been attributed to S. immune evasion. Here, we report on a monoclonal antibody, 514G3, that circumvents key evasion mechanism by targeting cell wall moiety Protein A (SpA). SpA tightly binds most subclasses of immunoglobulins via their Fc region, neutralizing effector...
Acute respiratory distress syndrome (ARDS) in COVID-19 has been associated with catastrophic inflammation. We present measurements humans and a new animal model implicating role danger-associated molecular patterns. Calprotectin (S100A8/A9) high-mobility group box 1 (HMGB1) were measured patients without/with ARDS, admission calprotectin was soluble urokinase plasminogen activator receptor (suPAR). An developed by intravenous injection of plasma from healthy or ARDS into C57/BL6 mice once...
Bermekimab is a true human monoclonal antibody that targets interleukin-1alpa (IL-1α), an inflammation-mediating alarmin. IL-1 receptor antagonist (IL-1Ra) natural molecule blocks IL-1α activity by occupying the receptor. The effect of endogenous IL-1Ra levels on effectiveness bermekimab unknown. We investigated whether pre-treatment circulating IL-1Ra, assessed enzyme-linked immunoassay, correlated with achievement primary outcome endpoint (effect lean body mass and symptoms at week 8) in...
In the tumour microenvironment, IL-1α promotes neoangiogenesis, matrix remodelling, proliferation, chemoresistance, and metastases. Highly expressed in human colorectal cancers, is associated with poor prognosis. XB2001, a fully monoclonal antibody neutralizing IL-1α, was evaluated for safety preliminary efficacy trifluridine/tipiracil (FTD/TPI) bevacizumab metastatic cancer patients previously treated oxaliplatin- irinotecan-based chemotherapies. This single institution, phase 1 study used...
Abstract Background: IL-1 is associated with pathological inflammatory responses, including inflammation that supports a malignant phenotype in the tumor microenvironment. Targeting IL-1α may reduce potential by undermining one or more aspects of tumor-driven angiogenesis, tissue matrix remodeling and metastasis. MABp1 true human therapeutic antibody generated natural immune response was cloned directly from peripheral B lymphocyte. binds high-affinity potent blocker biological activity....