A5029884274- HIV Research and Treatment
- Urinary Tract Infections Management
- Pneumonia and Respiratory Infections
- HIV/AIDS Research and Interventions
- Bacterial Infections and Vaccines
- HIV, Drug Use, Sexual Risk
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Antibiotic Resistance in Bacteria
- Streptococcal Infections and Treatments
- HIV-related health complications and treatments
- Urinary Bladder and Prostate Research
- HIV/AIDS drug development and treatment
- Infective Endocarditis Diagnosis and Management
- Hepatitis B Virus Studies
- Antibiotic Use and Resistance
- Pediatric Urology and Nephrology Studies
- Antimicrobial Resistance in Staphylococcus
- Otolaryngology and Infectious Diseases
- SARS-CoV-2 and COVID-19 Research
- Child Abuse and Trauma
- Pneumocystis jirovecii pneumonia detection and treatment
- Sepsis Diagnosis and Treatment
- Nosocomial Infections in ICU
- Migration, Health and Trauma
Space Hellas (Greece)
2024
Gilead Sciences (United States)
2021
University General Hospital Attikon
2005-2017
National and Kapodistrian University of Athens
2008-2017
Athens State University
2016
Eginition Hospital
2016
Chelsea and Westminster Hospital
2014
Sismanoglio General Hospital
2000-2001
Although major changes of the immune system have been described in sepsis, it has never studied whether these may differ relation to type underlying infection or not. This was for first time.The statuses innate and adaptive systems were prospectively compared 505 patients. Whole blood sampled within less than 24 hours advent sepsis; white cells stained with monoclonal antibodies analyzed though a flow cytometer.Expression HLA-DR significantly decreased among patients severe sepsis/shock due...
Remdesivir shortens time to recovery in adults with severe coronavirus disease 2019 (COVID-19), but its efficacy and safety children are unknown. We describe outcomes COVID-19 treated remdesivir.Seventy-seven hospitalized patients <18 years old confirmed acute respiratory syndrome 2 infection received remdesivir through a compassionate-use program between March 21 April 22, 2020. The intended treatment course was 10 days (200 mg on day 1 100 daily subsequently for ≥40 kg 5 mg/kg 2.5 <40 kg,...
The heptavalent pneumococcal conjugate vaccine (PCV7) has a considerable effect on the epidemiology of disease. aim this observational hospital-based study was to examine PCV7 (introduced in our settings 2004) spontaneously draining acute otitis media.Results all middle ear fluid cultures (n = 3446) obtained from children with media complicated otorrhea before introduction immunization (between 2000 and 2003) were compared those 2134) during similar post-PCV7 period 2005 2008). Results...
ObjectivesTo study the performance of Becton-Dickinson Link 2 Strep A Rapid Test, a rapid antigen detection test (RADT) for diagnosing streptococcal pharyngitis in children presenting to private offices and Pediatric Outpatient Clinic university hospital, relation clinical criteria (fever, tender anterior cervical lymph nodes, tonsillar exudate absence cough), its impact on antibiotic prescription.
Extended-spectrum β-lactamases (ESBLs) have emerged as an important mechanism of β-lactam resistance among community uropathogens. We characterized the ESBLs a collection Escherichia coli isolates recovered from outpatients with urinary tract infection during nationwide surveillance conducted 2005 to 2006 in Greece, and evaluated vitro activity mecillinam mecillinam/clavulanate against them. were PCR sequencing. In interactions agar dilution without clavulanate (4 mg/L) using inoculum 104 or...
Abstract Background Idiopathic sclerosing encapsulating peritonitis (or abdominal cocoon) is a rare cause of small bowel obstruction, especially in adult population. Diagnosis usually incidental at laparotomy. We discuss one such case, outlining the fact that an intra-operative surprise diagnosis could have been facilitated by previous investigations. Case presentation A 56 year-old man presented A&E department with ileus. He had history 6 similar episodes obstruction past 4 years, which...
AbstractA unique case of septic arthritis caused by Salmonella enteritidis in a patient receiving infliximab for rheumatoid is presented. Antimicrobial chemotherapy with surgical intervention was necessary eradication the infection. Physicians should be aware rare manifestations infections associated use, especially endemic areas.
A nation-wide surveillance study was conducted in Greece order to provide a representative depiction of pneumococcal carriage the pre-vaccination era and evaluate potential risk factors for resistant strains healthy preschool children attending daycare centers.A group organized with responsibility collect nasopharyngeal samples from children. Questionnaires provided demographic data, data on antibiotic consumption, family household medical history data. Pneumococcal isolates were tested...
Antibiotic resistance, a major public health problem, has been linked to antibiotic consumption. In Greece both consumption and resistance rates are among the highest in Europe. A multifaceted campaign targeting physicians parents of school children was implemented for first time order educate update doctors, aiming promote judicious use antibiotics hopefully decrease its consumption.The programme consisted education academic detailing primary care district Corinth Peloponnese. The...
OBJECTIVE To evaluate the efficacy of copper-coating in reducing environmental colonization an intensive-care unit (ICU) with multidrug-resistant-organism (MDRO) endemicity DESIGN Interventional, comparative crossover trial SETTING The general ICU Attikon University hospital Athens, Greece PATIENTS Those admitted to compartments A and B during study period METHODS Before any intervention (phase 1), optimum sampling method using 2 nylon swabs was validated. In phase 2, 6 copper-coated beds...
Abstract Objectives HIV late presentation (LP) has been increasing in recent years Europe. Our aim was to investigate the characteristics of LP Greece using addition traditional definition for LP, time interval between infection and diagnosis. Methods nationwide sample included HIV‐1 sequences generated from 6166 people living with (PLWH) during period 1999–2015. analysis based on molecularly inferred dates PLWH infected within local molecular transmission clusters subtypes A1 B. Results...
Remdesivir was the first antiviral approved for treating COVID-19. We investigated its patterns of use, effectiveness and safety in clinical practice Greece. This is a retrospective observational study hospitalized adults who received remdesivir COVID-19 September 2020-February 2021. The main endpoints were time to recovery (hospital discharge within 30 days from admission) safety. "early" (remdesivir initiation 24 h since hospitalization) "deferred" later on) groups compared. One thousand...
Background Late HIV diagnosis (CD4 + T-cell count < 350 cells/μL, or with an AIDS-defining event) remains a persistent challenge in Greece, indicating potential missed opportunities (MOs) for earlier testing. Aim To determine the frequency of indicator conditions (ICs) preceding and to quantify MOs testing at nationwide level Greece. Methods This multicentre retrospective study analysed data on 823 antiretroviral therapy-naive adults (≥ 18 years) diagnosed during 2019–21. Medical records...
Abstract Background To investigate a possible role of Cefditoren, recently marketed in Greece third-generation oral cephalosporin urinary infections outpatients. Methods During multicenter survey Enterobacteriaceae causing UTIs outpatients during 2005–2007, Cefditoren MICs were determined by agar dilution method randomly selected sample uropathogens. Susceptibility against 18 other oral/parenteral antimicrobials was according to Clinical and Laboratory Standards Institute methodology....
A cohort study of patients (pts) presenting with symptoms chronic prostatitis over 2 years was performed. Appropriate antimicrobials were administered to confirmed cases bacterial (CBP) after a Stamey-meares (S-M) test for period 6 weeks and the repeated 1 months post therapy completion. 145 male presented evaluation. most prevalent included dysuria (68%), frequency (38%), pain which present in 50%. S-M testing performed 69% expressed prostatic specimen collected 53.8%. diagnosis CBP...
People living with HIV (PLWH) are at high cardiovascular disease (CVD) risk. Traditional CVD risk scores do not accurately reflect their Noninvasive subclinical vascular damage (SVD) biomarkers valid surrogates of and able to stratify risk.We tested whether 4 widely applied [Framingham (FRS), Atherosclerotic CVD, Data Collection on Adverse Effects Anti-HIV Drugs Study (D:A:D), Greek-specific European Society Cardiology (ESC) scores] associated or detect the presence, incidence, progression...
The Greek version of the Davidson Trauma Scale (DTS) was developed to respond need Greek-speaking individuals. translated questionnaire administered 128 HIV outpatients (aged 37.1±9.1) and 166 control patients 32.4±13.4). In addition DTS scale, subjects were assessed with two other scales useful for assessing validity. For each factor analyses components extracted, based on Cattell's scree test. solution accounted 55.34% total variation in case frequency variables 61.45% severity variables....
Hyperbilirubinaemia with or without jaundice is one of the side effects atazanavir boosted low-dose ritonavir (ATV/rit) related to drug plasma levels, as a result its metabolism by UGT1A1 – uridine diphosphate-glucuronosyl transferase. Genotyping for UGT1A1*28 before initiation antiretroviral therapy containing may aid in identifying individuals at risk hyperbilirubinaemia. Our objective was estimate prevalence UGTA1A1*28 polymorphism HIV-infected Greece and determine potential association...