A5102783012- Exercise and Physiological Responses
- Muscle Physiology and Disorders
- Infectious Diseases and Mycology
- Cancer-related Molecular Pathways
- Actinomycetales infections and treatment
- Immune Cell Function and Interaction
- Wnt/β-catenin signaling in development and cancer
- Cell Adhesion Molecules Research
- Infectious Diseases and Tuberculosis
- Sharing Economy and Platforms
- Antibiotic Resistance in Bacteria
- Cancer Cells and Metastasis
- Tracheal and airway disorders
- Osteomyelitis and Bone Disorders Research
- Autoimmune and Inflammatory Disorders Research
- Angiogenesis and VEGF in Cancer
- Long-Term Effects of COVID-19
- Systemic Lupus Erythematosus Research
- Orthopedic Infections and Treatments
- Antibiotics Pharmacokinetics and Efficacy
- Cellular Mechanics and Interactions
- Vascular Anomalies and Treatments
- COVID-19 Clinical Research Studies
- Cancer Diagnosis and Treatment
- Viral Infections and Vectors
Evangelismos Hospital
2012-2025
Agios Pavlos General Hospital
2024
National and Kapodistrian University of Athens
2006-2020
Red Cross Hospital
2020
University General Hospital Attikon
2012
Division of Chemistry
2010
Foundation for Research and Technology Hellas
2008
FORTH Institute of Applied and Computational Mathematics
2008
Emory University
2006
University of Toledo
1999-2003
Abstract Objective The concept that intraarticular crystals of uric acid by themselves trigger episodes painful gouty arthritis is inconsistent with the clinical reality. Patients large deposits monosodium urate monohydrate (MSU) (tophi) do not necessarily experience attacks. In fact, it excessive consumption food or alcohol elicits inflammation acute gout attack. aim this study was to identify precise mechanism initiates flares arthritis. Methods Human peripheral blood mononuclear cells...
Monosodium urate monohydrate (MSU) crystals synergize with various toll-like receptor (TLR) ligands to induce cytokine production via activation of the NOD-like (NLR) family, pyrin domain-containing 3 (NLPR3) inflammasome. This has been demonstrated in vitro using human cell lines or monocytes healthy volunteers. In present study, we have investigated effect MSU and their combination TLR peripheral blood mononuclear cells (PBMC) patients gout.PBMCs from 18 primary gout 12 donors were exposed...
Abstract CD44 is a transmembrane protein that plays role in cell–cell interactions and motility number of cell types. Cell–cell are critical for myoblast differentiation fusion but whether regulates myogenesis unknown. Here, we show functional early myogenesis. Analyses myofiber cross‐sectional area, after local injury mouse tibialis anterior (TA) muscles, revealed growth was transiently delayed the absence CD44. A muscle‐intrinsic suggested as primary myoblasts from −/− mice displayed...
Modified muscle use can result in atrophy and impairment. We tested whether inflammatory cell concentrations correlate temporally with impairment during modified loading periods. Rat hindlimbs were unloaded for 10 days followed by reloading. The density of neutrophils ED1 + macrophages was significantly increased 16.5- 9.8-fold, respectively, after 1 day ED2 macrophage concentration not until 3 Maximal isometric tetanic tension (P o ; N/cm 2 ) decreased hindlimb suspension (HS), which a...
PETERSON, J. M., T. A. TRAPPE, E. MYLONA, F. WHITE, C. P. LAMBERT, W. EVANS, and X. PIZZA. Ibuprofen Acetaminophen: Effect on Muscle Inflammation after Eccentric Exercise. Med. Sci. Sports Exerc., Vol. 35, No. 6, pp. 892–896, 2003. Purpose We examined the influence of ibuprofen acetaminophen muscle neutrophil macrophage concentrations novel eccentric contractions. Methods Twenty-four males (25 ± 3 yr) were divided into three groups that received maximal over-the-counter dose either (1200...
Background/Objectives: The aim of the present study is to report an outbreak bloodstream infections caused by Serratia marcescens in patients undergoing postoperational procedures Cardiothoracic Department and describe epidemiological investigations control measures undertaken. A cluster bacteremia due was identified blood cultures from postoperative Surgery November 2023. Methods: Active surveillance hospital’s prevention team initiated. Interviews with nurses sanitary personnel reviews...
We determined the effect of muscle contractions resulting from high-frequency electrical stimulation (HFES) on inflammatory cells in rat tibialis anterior (TA), plantaris (Pln), and soleus (Sol) muscles at 6, 24, 72 h post-HFES. A minimum four a maximum seven rats were analyzed each time point. HFES, applied to sciatic nerve, caused Sol Pln contract concentrically TA eccentrically. Neutrophils higher ( P < 0.05) 6 24 after HFES Sol, Pln, relative control muscles. ED1 + macrophages...
Bakarakos P, Theohari I, Nomikos A, Mylona E, Papadimitriou C, Dimopoulos A‐M & Nakopoulou L (2010) Histopathology 56, 876–882 Immunohistochemical study of PTEN and phosphorylated mTOR proteins in familial sporadic invasive breast carcinomas Aims: Loss phosphatase tensin homologue (PTEN) leads to activation several kinases, including mammalian target rapamycin (mTOR), which promotes cell cycle progression. The aim was the expression (p)‐mTOR their relation clinicopathological features,...
The purpose of this study was to 1) test the hypothesis that skeletal muscle cells (myotubes) after mechanical loading and/or injury are a source soluble factors promote neutrophil chemotaxis and superoxide anion (O(2)(-).) production 2) determine whether causes myotubes release cytokines known influence responses [tumor necrosis factor-alpha (TNF-alpha), IL-8, transforming growth factor-beta1 (TGF-beta1)]. Human were grown in culture exposed either cyclic strain (0, 5, 10, 20, or 30%...
Abstract Introduction Our aim was to study the expression pattern of tissue inhibitor metalloproteinases (TIMP)-3 protein in invasive breast carcinoma, and its clinicopathological prognostic value as well relation markers indicative tumor phenotype. Methods Immunohistochemistry performed on paraffin-embedded specimens from 173 carcinomas detect proteins TIMP-3, estrogen receptor (ER), progesterone receptor, p53, c-erbB-2, topoisomerase IIα Bcl-2. Results TIMP-3 immunodetected cytoplasm...
Aims: To study the clinicopathological and prognostic value of cyclin D1 overexpression in patients with breast carcinoma. Methods results: Immunohistochemistry was performed on paraffin‐embedded tissue specimens from 290 invasive carcinomas to detect proteins D1, oestrogen receptor (ER), progesterone (PR), p53, c‐erbB2, topoisomerase IIα (topoIIα). Cyclin staining quantified using a computerized image analysis method. characterized smaller, ER‐positive PR‐positive tumours ( P = 0.017, <...
Hereditary hemorrhagic telangiectasia (HHT) is a disease characterized by arteriovenous malformations (AVMs). Brain abscess complication of HHT with AVMs. Literature provides evidence that Enterococcus faecalis can cause endodontic infections. We present the case an patient who developed brain due to E. after dental procedure.
Data on the clinical features and outcomes of COVID-19 patients from countries with low disease burden are rare. Greece, however, presented a during first pandemic outbreak. This is retrospective study hospitalized in Greece. Clinical data were extracted medical records using univariable multivariable logistic regression analyses to assess factors associated Intensive Care Unit (ICU) admission in-hospital death. Eighty-five included this study, 49 (57.7%) male median (25
Kisspeptins, the products of KISS 1 gene, are involved in cancer invasion, migration, metastasis and angiogenesis, while they induce apoptosis various cancers. Herein, we studied expression colorectal cancer. We analyzed using immunohistochemistry image analysis normal malignant tissue samples from 60 patients with adenocarcinoma. The results correlated clinicopathological parameters. was much higher than colonic mucosa. However, among tissues, larger tumors (>4 cm) smaller ones (≤4...