A5046998243- Rice Cultivation and Yield Improvement
- Malaria Research and Control
- Health, Medicine and Society
- Global Maternal and Child Health
- Mosquito-borne diseases and control
- Neonatal Respiratory Health Research
- Mental Health Treatment and Access
- Neonatal and fetal brain pathology
- Complement system in diseases
- Migration, Identity, and Health
- Healthcare Systems and Practices
- Virology and Viral Diseases
- Child Nutrition and Water Access
- Schizophrenia research and treatment
- Blood donation and transfusion practices
- Manufacturing Process and Optimization
- Parasites and Host Interactions
- Viral Infections and Outbreaks Research
- Appendicitis Diagnosis and Management
- Emergency and Acute Care Studies
- Vaccine Coverage and Hesitancy
- Immunodeficiency and Autoimmune Disorders
- Health Education and Validation
- RNA Research and Splicing
- Nuclear Structure and Function
Mali-Folkecenter
2015-2024
University of Bamako
2013-2024
Université des Sciences, des Techniques et des Technologies de Bamako
2013-2024
Centre Pour le Développement des Vaccins-Mali
2023
Clinique Romande de Réadaptation
2019-2021
University Teaching Hospital
2021
Centre Hospitalier Sud Francilien
2018-2019
Centre Hospitalier National Universitaire de Fann
2016
Wenner-Gren Foundations
2013
Stockholm University
2013
Infectious diseases exert a constant evolutionary pressure on the genetic makeup of our innate immune system. Polymorphisms in Toll-like receptor 4 (TLR4) have been related to susceptibility Gram-negative infections and septic shock. Here we show that two polymorphisms TLR4, Asp299Gly Thr399Ile, unique distributions populations from Africa, Asia, Europe. Genetic functional studies are compatible with model which nonsynonymous polymorphism has evolved as protective allele against malaria,...
We compared malaria indicators among sympatric groups to study human heterogeneities in the response Plasmodium falciparum infection. Four cross-sectional surveys and two longitudinal ethnic (Dogon Fulani) Mali were carried out from 1998 2000. Spleen parasite rates evaluated during disease incidence was assessed surveys. In spite of similar sociocultural factors entomologic inoculation between groups, Fulani had a significantly higher spleen enlargement rate, lower less affected by than...
Adequate responses by our innate immune system toward invading pathogens were of vital importance for surviving infections, especially before the antibiotic era. Recently, a polymorphism in Mal (Ser180Leu, TIRAP rs8177374), an important adaptor protein downstream Toll-like receptor (TLR) 2 and 4 pathways, has been described to provide protection against broad range infectious pathogens. We assessed functional effects this human experimental endotoxemia, we demonstrate that individuals...
The present study carried out at the Central Veterinary Laboratory of Mali (LCV) aimed to determine stability DERMAPOX vaccine after its reconstitution. It focused on (03) pilot batches against Contagious Bovine Lumpy Skin Disease (LSD) codenamed DERMAPOX. Batches Nos. Pox 001, 002 and 003 produced according Good Manufacturing Practices. production quality control procedures culture media, semi-finished finished product solutions did in accordance with protocol manual LCV Pan African Vaccine...
Interethnic differences in susceptibility to malaria provide a unique opportunity explore immunological correlates of protection. The Fulani Sahelian Africa are known for their reduced Plasmodium falciparum, compared with surrounding tribes, yet the immunology underlying this is still poorly understood.Here, we show that mononuclear cells from elicit >10-fold stronger interferon (IFN)-gamma production following 24-h vitro coincubation asexual parasites than sympatric Dogon. This response...
Many studies report associations between human genetic factors and immunity to malaria but few have been reliably replicated. These are usually country-specific, use small sample sizes not directly comparable due differences in methodologies. This study brings together samples data collected from multiple sites across Africa Asia standardized methods look for consistent effects on anti-malarial antibody levels.Sera, DNA clinical were 13,299 individuals ten Senegal, Mali, Burkina Faso, Sudan,...
It has been previously shown that there are some interethnic differences in susceptibility to malaria between two sympatric ethnic groups of Mali, the Fulani and Dogon. The lower Plasmodium falciparum seen not fully explained by genetic polymorphisms known be associated with resistance, including haemoglobin S (HbS), C (HbC), alpha-thalassaemia glucose-6-phosphate dehydrogenase (G6PD) deficiency. Given observed distribution FcγRIIa allotypes among different have reported, we analysed...
Background Caspase-12 functions as an antiinflammatory enzyme inhibiting caspase-1 and the NOD2/RIP2 pathways. Due to increased susceptibility sepsis in individuals with functional caspase-12, early-stop mutation leading loss of caspase-12 has replaced ancient genotype Eurasia a significant proportion from African populations. In African-Americans, it been shown that inhibits pro-inflammatory cytokine production. Methodology/Principal Findings We assessed whether similar mechanisms are...
Fusarium head blight is a serious problem in both traditional and intensive agriculture. The way to solve this use combined systemic fungicides. We therefore studied the effect of new-generation fungicides Alto Super KE (Propiconazole 250 g/l Ciproconazole 80 g/l) with foliar fertilizer Ultramag Sulphur-900. Laboratory studies were carried out at Plant Pathology People's Friendship University Russia (RUDN), field experiments 2022 experimental station Federal Research Centre...
The full-length (L-) variant of caspase-12 is believed to predispose sepsis. It has been replaced in the genome most human populations by (S-) variant, which leads premature termination translation. Strikingly, L-allele still widely prevalent African populations, presumably due a counterbalancing selective force specific this continent, for malaria prime candidate.We investigated associations between genotype and malarial parameters three West-African studies encompassing immunological,...
Abstract Background Schizophrenia is a relatively common disease worldwide with point prevalence of around 5/1000 in the population. The aim this present work was to assess demographic, clinical, familial, and environmental factors associated schizophrenia Mali. Methods This prospective descriptive study on series 164 patients aged at least 12 years who came for follow-up consultation psychiatry department University Hospital Center (CHU) Point G Mali between February 2019 January 2020...
Despite significant progress in the field of scientific research on Parkinson's disease (PD), prevalence and pathophysiology its non-motor signs remains less understood than classic motor bradykinesia, rigidity, tremor postural instability. Data covering this topic are rare Africa, almost non-existent sub-Saharan Africa. Thus, study aims to highlight frequency certain PD patients followed Department Neurology University Hospital Point "G", Bamako, Mali.This is a retrospective descriptive...
Vaccine-preventable diseases (VPDs) persist globally with a disproportionately high burden in Low and Middle-Income Countries (LMICs). Although this might be partly due to the failure sustain vaccination coverage above 90% some WHO regions, more nuanced understanding of VPD transmission beyond may unveil other important factors control. This study identified VPDs hotspots explored their relationships ecology, urbanicity land-use variations (Artisanal Small-scale Gold Mining (ASGM)...
Abstract Background: GNE myopathy (GM) is a rare autosomal recessive disorder caused by variants in the gene and characterized progressive distal muscle weakness atrophy. We report novel variant causing GM consanguineous Malian family. Case presentation: A 19-year-old male patient from family of Bambara ethnicity was seen for walking difficulty frequent falls. Neurological examination found distalmuscle atrophy reduced tendon reflexes four limbs. Electroneuromyography (ENMG) showed an axonal...
Abstract Introduction Malaria is a health threat in sub‐Saharan Africa, where Plasmodium not tested blood bags. Our objective was to determine the prevalence of plasmodial carriage bags and associated factors, involvement these occurrence malaria recipients. Methods From 1st April 30th November, 2020, we conducted prospective cross‐sectional study 348 stored at 4°C Bamako. Using SPSS 21.0 software, statistical analyses were performed using binary logistic regression model with significance...
Objectif: L'objectif de cette étude était déterminer la prévalence consommation des substances psychoactives parmi les patients hospitalisés en psychiatrie au Centre Hospitalier Universitaire Point G. Méthodes: Il s’agissait d’une enquête transversale portant sur dossiers pour troubles psychiatriques entre janvier 2014 et décembre 2018. Résultats Sur cinq années d’activité clinique du service G, 1105 ont été inclus dans l’étude. La fréquence globale 42,9% hospitalisés. Une élevée drogues...