A5104623009- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Gestational Diabetes Research and Management
- Cancer Immunotherapy and Biomarkers
- Organ Transplantation Techniques and Outcomes
- Cancer-related gene regulation
- Cardiac Ischemia and Reperfusion
- Fluoride Effects and Removal
- Skin Protection and Aging
- Eosinophilic Disorders and Syndromes
- Pregnancy and preeclampsia studies
- Cancer, Stress, Anesthesia, and Immune Response
- Congenital Anomalies and Fetal Surgery
- Redox biology and oxidative stress
- Viral-associated cancers and disorders
- Bladder and Urothelial Cancer Treatments
- Berberine and alkaloids research
- Corneal surgery and disorders
- Cardiac Valve Diseases and Treatments
- Corneal Surgery and Treatments
- Urinary and Genital Oncology Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Ureteral procedures and complications
- Diet and metabolism studies
National Taiwan University Hospital
2006-2025
Chung Shan Medical University Hospital
2021-2024
Taipei Veterans General Hospital
2024
National Yang Ming Chiao Tung University
2024
University of North Carolina at Chapel Hill
2022
Taipei Medical University Hospital
2006-2009
Taipei Medical University
2006-2009
Chi Mei Medical Center
2006
University of California, Los Angeles
1972
To generate a single-cell RNA-sequencing (scRNA-seq) map and construct cell-cell communication networks of mouse corneas.C57BL/6 corneas were dissociated to single cells subjected scRNA-seq. Cell populations clustered annotated for bioinformatic analysis using the R package "Seurat." Differential expression patterns validated spatially mapped with whole-mount immunofluorescence staining. Global intercellular signaling constructed CellChat.Unbiased clustering scRNA-seq transcriptomes 14,732...
Corticosteroid is effective in alleviating immune-related adverse events (irAEs) of immune checkpoint blockade (ICB). However, prophylactic use corticosteroid to prevent irAEs not recommended due a looming concern that it may attenuate anti-tumor effect ICB. This study aims investigate whether premedication compromise efficacy dual ICB, regimen cause significant irAEs. Orthotopic BNL 1MEA.7R.1 and subcutaneous Hepa1-6 syngeneic hepatocellular carcinoma (HCC) models were used. Low-dose (LD;...
The purpose of this study was to determine whether N-acetylcysteine (NAC) attenuates cardiac sympathetic hyperinnervation through replenishment glutathione in infarcted rats.After ligation the coronary artery, male Wistar rats were randomized either vehicle, NAC, or vitamins C + E groups for 4 weeks. Post-infarction associated with increased oxidant release, as measured by tissue isoprostane and myocardial glutathione. Measurement norepinephrine levels revealed a significant elevation...
Favorable testicular cancer mortality-to-incidence ratios (MIRs) are associated with health care disparities, including expenditures, but the trends of MIR and disparity remain unclear. We evaluated changes in as difference between 2012 2018, termed delta (δMIR). Health expenditures human development index (HDI) were obtained from World Organization Human Development Report Office United Nations Programme. The association variables was analyzed by Spearman’s rank correlation coefficient. A...
Eosinophilic esophagitis (EoE) is a clinicopathologic condition that characterized by chronic inflammation with variable manifestations.1 Esophageal strictures are one of the fibrotic remodeling features EoE and more commonly seen diagnostic delay.2 Recognition important given their role in complications EoE, such as food impactions, because dilation can safely provide significant symptomatic benefit.3,4 While it has been frequently demonstrated incidence prevalence have increasing, unknown...
Pancreatic adenocarcinoma is often not diagnosed until an advanced stage, and so most patients are eligible for resection. For who inoperable, definitive radiotherapy crucial local disease control. However, the pancreas located close to other vulnerable gastrointestinal organs, making it challenging deliver adequate radiation dose. The surgical insertion of spacers or injection fluids such as hydrogel before has been proposed, however, no study discussed which suitable procedure.
Background: The incidence of upper tract urothelial carcinoma (UTUC) is uniquely high in kidney transplant (KT) recipients Taiwan. evidence adjuvant chemotherapy (AC) UTUC contradictory. We have sought to determine whether AC associated with potential benefits related locally advanced after KT. Methods: retrospectively analyzed 134 patients (at least stage T2) and who were administrated unilateral or bilateral nephroureterectomy bladder cuff excision. Of these patients, 57 fulfilled our...
e14596 Background: Immune-related adverse events (irAEs) are major hurdle to immune checkpoint blockade (ICB). Corticosteroid (CS) is effective in controlling the majority of irAEs. Although recent studies suggested CS use does not jeopardize anti-tumor efficacy ICB, prophylactic remains prohibited with concerns attenuating ICB. This study aimed investigate effects premedication on ICB murine hepatocellular carcinoma models. Methods: Anti-mCTLA-4 (9D9C, BMS) and anti-mPD-1 antibodies (4H2,...
ISEE-188 Objectives: Oxidative stress on pregnant women plays an important role in low birth weight. Vitamin C major providing the antioxidant defense against oxygen free radicals. This vitamin is transported to fetus second and third trimester of pregnancy. study aims evaluate protective effect adverse oxidative Methods: Pregnant women, who visited Ewha Womans University Hospital for prenatal care, participated this from their 24th 28th gestational weeks. We included 318 healthy singleton...
Supplementary Figure Legends 1-6 from Functional Genomic Analysis Identified Epidermal Growth Factor Receptor Activation as the Most Common Genetic Event in Oral Squamous Cell Carcinoma
Supplementary Figures 1-6 from Functional Genomic Analysis Identified Epidermal Growth Factor Receptor Activation as the Most Common Genetic Event in Oral Squamous Cell Carcinoma
Supplementary Figure Legends 1-6 from Functional Genomic Analysis Identified Epidermal Growth Factor Receptor Activation as the Most Common Genetic Event in Oral Squamous Cell Carcinoma
Supplementary Figures 1-6 from Functional Genomic Analysis Identified Epidermal Growth Factor Receptor Activation as the Most Common Genetic Event in Oral Squamous Cell Carcinoma
<div>Abstract<p>A 250K single-nucleotide polymorphism array was used to study subchromosomal alterations in oral squamous cell carcinoma (OSCC). The most frequent amplification found at 7p11.2 9 of 29 (31%) cancer patients. Minimal genomic mapping verified a unique amplicon spanning from 54.6 55.3 Mb on chromosome 7, which contains <i>SEC61G</i> and <i>epidermal growth factor receptor</i> (<i>EGFR</i>). Results fluorescence <i>in...
ISEE-190 Objectives: Vitamin deficiency during pregnancy increases maternal oxidative stress and leads to adverse outcome. These effects might be continued through postnatal period. This study aims determine the effect of prenatal antioxidative vitamin levels on growth using prospective study. Methods: The subjects were 360 infants who delivered from healthy pregnant women visited an obstetric clinic for antenatal care their singleton live births, in Seoul, Korea, between August 2001 March...