A5103232568- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Musculoskeletal synovial abnormalities and treatments
- Lymphoma Diagnosis and Treatment
- IgG4-Related and Inflammatory Diseases
- Neuroendocrine Tumor Research Advances
- Tumors and Oncological Cases
- Oral and Maxillofacial Pathology
- Cutaneous lymphoproliferative disorders research
- Soft tissue tumor case studies
- Histiocytic Disorders and Treatments
- Soft tissue tumors and treatment
- Dementia and Cognitive Impairment Research
- Vascular Tumors and Angiosarcomas
- Cardiac tumors and thrombi
- CNS Lymphoma Diagnosis and Treatment
- RNA regulation and disease
- Urologic and reproductive health conditions
- Chronic Lymphocytic Leukemia Research
- Alzheimer's disease research and treatments
- Gastrointestinal disorders and treatments
- Viral-associated cancers and disorders
- Cancer Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Glioma Diagnosis and Treatment
Royal Hallamshire Hospital
2011-2025
Sheffield Teaching Hospitals NHS Foundation Trust
2014-2025
Hudson Institute
2023
John Wiley & Sons (United States)
2023
United States Nuclear Regulatory Commission
2019
Jessop Hospital
2019
Imperial College Healthcare NHS Trust
2019
Hammersmith Hospital
2019
Northern General Hospital
2018
Singapore General Hospital
2017
Background and Purpose— “Incidental” MRI white matter (WM) lesions, comprising periventricular lesions (PVLs) deep subcortical (DSCLs), are common in the aging brain. Direct evidence of ischemia associated with incidental WM (WMLs) has been lacking, their pathogenesis is unresolved. Methods— A population-based, postmortem cohort (n=456) donated brains was examined by pathology. In a subsample whole cohort, magnetic resonance images were used to sample compare WMLs nonlesional for molecular...
White matter lesions (WML) on magnetic resonance imaging (MRI) brain scans are associated with ageing. They unrelated to specific disorders, and their impact cognitive other functions is poorly characterized. Pathological studies often omit systematic survey of WML because the need study multiple full coronal tissue blocks, uncertainty over significance identified in periventricular deep subcortical regions. Post‐mortem MRI provides a means mapping but sensitivity specificity method...
Vascular endothelial growth factor (VEGF) prolongs survival in the mutant SOD1 transgenic mouse model of amyotrophic lateral sclerosis (ALS), whereas dysregulation VEGF through deletion its hypoxia-regulatory element causes motor neuron degeneration mice. We investigated expression and major agonist receptors normal central nervous system patients with ALS. Immunohistochemistry demonstrated similar patterns receptor 2 (VEGFR2) spinal cord finely punctate staining neuropil strong anterior...
White matter lesions (WML) in brain aging are linked to dementia and depression. Ischemia contributes their pathogenesis but other mechanisms may contribute. We used RNA microarray analysis with functional pathway grouping as an unbiased approach investigate evidence for additional pathogenetic mechanisms.WML were identified by MRI pathology brains donated the Medical Research Council Cognitive Function Ageing Study Aging Study. was extracted compare WML nonlesional white samples from cases...
<h3>Aims</h3> To determine the role of serum and tissue IgG2 in orbital biopsies with histological features IgG4-related disease (IgG4-RD) comparison non-IgG4-related inflammatory disorders (OID), including autoimmune disorders. <h3>Methods</h3> This is an international (Sheffield, UK, Singapore) collaborative, retrospective case review 69 patients (38 from Singapore National Eye Centre 31 Royal Hallamshire Hospital, Sheffield) between 2002 2016. Clinical information histology were reviewed...
// Abhijit A. Patil 1 , Parag Sayal 2 Marie-Lise Depondt Ryan D. Beveridge Anthony Roylance Deepti H. Kriplani Katie N. Myers Angela Cox David Jellinek Malee Fernando 3 Thomas Carroll and Spencer J. Collis Sheffield Cancer Research Centre, Academic Unit of Molecular Oncology, Department University Medical School, Beech Hill Road, Sheffield, UK Neuro-Oncology Group, Teaching Hospitals NHS Foundation Trust, Royal Hallamshire Hospital, Histopathology, Hospitals, Correspondence: email: Keywords...
Soft-tissue sarcomas (STS) are a diverse group of malignancies that remain diagnostic and therapeutic challenge. Relatively few reliable cell lines currently exist. Rapidly developing technology for genomic profiling with emerging insights into candidate functional (driver) aberrations raises the need more models in vitro validation molecular targets.Primary culture was performed on STS tumours utilising differential attachment approach. Cell were characterised by morphology,...
Abstract There is a paucity of population‐based data detailing the incidence and survival patients with soft tissue sarcoma (STS), in part due to heterogeneity disease changes classification. Here, all STS subtypes registered England between 2013 2017 were analysed using cancer registry held by National Cancer Registration Analysis Service. Age‐standardised rates calculated per 1 000 European Standard Population. Net was computed Brenner's alternative method, Ederer II estimator....
Most soft tissue sarcomas are characterized by genetic instability and frequent genomic copy number aberrations that not subtype-specific. Oligonucleotide microarray-based Comparative Genomic Hybridisation (array CGH) is an important technique used to map genome-wide aberrations, but the traditional requirement for high-quality DNA typically obtained from fresh has limited its use in sarcomas. Although large archives of Formalin-fixed Paraffin-embedded (FFPE) tumour samples available...
Summary Spontaneous remission of primary hyperparathyroidism (PHPT) due to necrosis and haemorrhage parathyroid adenoma, the so-called ‘parathyroid auto-infarction’ is a very rare, but previously described phenomenon. Patients usually undergo parathyroidectomy or remain under close clinical biochemical surveillance. We report two cases auto-infarction diagnosed in same tertiary centre; one managed surgically other conservatively up present time. Case #1 was 51-year old man with PHPT...
Brain tumours kill more children and adults under 40 than any other cancer, with approximately half of primary brain being diagnosed as high-grade malignancies known glioblastomas. Despite de-bulking surgery combined chemo-/radiotherapy regimens, the mean survival for these patients is only around 15 months, less 10% surviving over 5 years. This dismal prognosis highlights urgent need to develop novel agents improve treatment tumours. To address this need, we carried out a human kinome siRNA...
The autosomal dominant Birt-Hogg-Dubé syndrome is known to be associated with skin, lung and kidney lesions. It caused by heterozygous germline mutations in the folliculin gene has a high penetrance. We report case of 51 year old woman who presented laryngeal mass. Imaging confirmed mass centered on piriform sinus following excision histological examination lesion was composed polygonal cells abundant eosinophilic cytoplasm consistent rhabdomyoma. Laryngeal rhabdomyoma rare condition not...
Introduction . We present a case of an 89-year-old female who attended our surgical endocrine clinic with 3-month history left-sided neck lump. There was no past medical thyroid disease. Methods Following examination and further investigation, including core biopsy, diagnosis plasma cell granuloma the made. Biochemical testing function Thyroid Peroxidase Antibody in-keeping associated Hashimoto's thyroiditis. Results The patient treated conservatively thyroxine regularly seen in clinic. TSH...
Understanding of vascular substrates cognitive decline in the elderly is evolving to include a major emphasis on impact small vessel disease (SVD). While existing concepts multi-infarct dementia and strategic infarct remain valid, they present difficulty generalizing clinicopathological correlations from patient patient. The range significance lesions that should be included as manifestations SVD are unresolved, their on, association with, neurodegenerative changes. This mini-review...