A5080036318- Cardiovascular Syncope and Autonomic Disorders
- Dementia and Cognitive Impairment Research
- Neuropeptides and Animal Physiology
- Heart Rate Variability and Autonomic Control
- Receptor Mechanisms and Signaling
- Chemical Synthesis and Analysis
- Pharmacological Receptor Mechanisms and Effects
- Neuroscience and Neuropharmacology Research
- Psychosomatic Disorders and Their Treatments
- Health, Environment, Cognitive Aging
- Bioactive Compounds and Antitumor Agents
- Phenothiazines and Benzothiazines Synthesis and Activities
- Computational Drug Discovery Methods
- Cancer therapeutics and mechanisms
- Immune Cell Function and Interaction
- Synthesis and pharmacology of benzodiazepine derivatives
- Neurology and Historical Studies
- Cardiac Arrhythmias and Treatments
- Connective tissue disorders research
- Synthesis and properties of polymers
- Ethics in Clinical Research
- Alzheimer's disease research and treatments
- Sympathectomy and Hyperhidrosis Treatments
- Cholinesterase and Neurodegenerative Diseases
- Cardiovascular Health and Disease Prevention
King's College London
2020-2023
Coventry (United Kingdom)
2023
Jaguar Land Rover (United Kingdom)
2023
Charles River Laboratories (United Kingdom)
2016-2020
University College London
2013-2018
National Hospital for Neurology and Neurosurgery
2013-2018
Royal Holloway University of London
2018
Utah State University
2017
National Health Service
2015
Imperial College London
2011-2015
A series of high-affinity GABA(A) agonists with good oral bioavailability in rat and dog functional selectivity for the GABA(A)alpha2 -alpha3 subtypes is reported. The 7-trifluoromethylimidazopyrimidine 14g 7-propan-2-olimidazopyrimidine 14k are anxiolytic both conditioned unconditioned animal models anxiety minimal sedation observed at full BZ binding site occupancy.
Social isolation is likely to be recommended for older adults due COVID-19, with ongoing reduced clinical contact suggested this population. This has increased the need remote memory clinics, we therefore review literature, current practices and guidelines on organizing such focusing assessment of cognition, function other relevant measurements, proposing a novel pathway based three levels complexity: simple telephone or video-based interviews testing using available tests (Level 1),...
Functional decline in Alzheimer's disease (AD) is typically measured using single-time point subjective rating scales, which rely on direct observation or (caregiver) recall. Remote monitoring technologies (RMTs), such as smartphone applications, wearables, and home-based sensors, can change these periodic assessments to more frequent, even continuous, objective monitoring. The aim of the RADAR-AD study assess accuracy validity RMTs measuring functional a real-world environment across...
Etripamil is a fast-acting, intranasally administered calcium-channel blocker in development for on-demand therapy outside health-care setting paroxysmal supraventricular tachycardia. We aimed to evaluate the efficacy and safety of etripamil 70 mg nasal spray using symptom-prompted, repeat-dose regimen acute conversion atrioventricular-nodal-dependent tachycardia sinus rhythm within 30 min. RAPID was multicentre, randomised, placebo-controlled, event-driven trial, conducted at 160 sites North...
Aberrant production of amyloid-beta peptides by processing the beta-amyloid precursor protein leads to formation characteristic extracellular deposits which are thought be cause Alzheimer's disease. Therefore, inhibiting key enzymes responsible for peptide generation, beta- and gamma-secretase may offer an opportunity intervene with progression In human brain cell culture systems a heterogeneous population various truncations is detected at present, it unclear how they produced. We have used...
Thymidylate kinase (TMK) is an essential enzyme in bacterial DNA synthesis. The deoxythymidine monophosphate (dTMP) substrate binding pocket was targeted a rational-design, structure-supported effort, yielding unique series of antibacterial agents showing novel, induced-fit mode. Lead optimization, aided by X-ray crystallography, led to picomolar inhibitors both Streptococcus pneumoniae and Staphylococcus aureus TMK. MICs < 1 μg/mL were achieved against methicillin-resistant S. (MRSA),...
<h3>Objective</h3> To test the hypothesis that Joint hypermobility and autonomic dysfunction are over-expressed within neurodevelopmental disorders. is a widespread poorly recognized connective tissue condition with affected individuals overrepresented among panic anxiety disorders, irritable bowel syndrome, fibromyalgia, chronic fatigue. The relevance of to neuropsychiatric disorders developmental origin currently unknown, despite anecdotal case reports clinical suspicion link. Autonomic...
There have been previous reports of enhanced sympathoexcitation in autism spectrum disorder (ASD). However, there has no formal investigation autonomic dysfunction ASD. Also, the joint hypermobile form Ehlers-Danlos syndrome (hE-DS) that maybe overrepresented ASD and orthostatic related dysfunction. This study examined comorbidity ASD, hE-DS two UK national referral centers. Proven, documented globally accepted clinical investigations were used to assess neuro-cardiovascular function a...
The ability to associate touch with sight is essential for tasks that require physically interacting objects in the world. We propose a dataset paired visual and tactile data called Touch Go, which human collectors probe natural environments using sensors, while simultaneously recording egocentric video. In contrast previous efforts, have largely been confined lab settings or simulated environments, our spans large number of "in wild" scenes. To demonstrate dataset's effectiveness, we...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIdentification of L-Tryptophan Derivatives with Potent and Selective Antagonist Activity at the NK1 ReceptorAngus M. MacLeod, Kevin J. Merchant, Frederick Brookfield, Fintan Kelleher, Graeme Stevenson, Andrew P. Owens, Christopher Swain, Margaret A. Cascieri, Sharon Sadowski, Cite this: Med. Chem. 1994, 37, 9, 1269–1274Publication Date (Print):April 1, 1994Publication History Published online1 May 2002Published inissue 1 April...
Depersonalization disorder (DPD) is characterized by a subjective sense of unreality, disembodiment, emotional numbing and reduced psychogenic (sudomotor) sympathoexcitation.Three related experiments utilized escalating physical challenges in 14 DPD participants 16 controls aimed to elucidate (i) whether the cardiovascular sympathetic (SNS) parasympathetic (PNS) nervous systems are implicated pathophysiology (ii) if possible, determine blunted sympathoexcitation peripherally or centrally...
Keywords: heart rate variability, COVID-19 pandemic, community prevalence, networked hardware/software systems, digital epidemiology, Internet of Healthy Things (IoHT)
Clinical research with remote monitoring technologies (RMTs) has multiple advantages over standard paper-pencil tests, but also raises several ethical concerns. While studies have addressed the issue of governance big data in clinical from legal or perspectives, viewpoint local ethics committee (REC) members is underrepresented current literature. The aim this study therefore to find which specific challenges are raised by RECs context a large European on all syndromic stages Alzheimer's...