A5053341926- Cardiovascular Syncope and Autonomic Disorders
- Heart Rate Variability and Autonomic Control
- Parkinson's Disease Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Botulinum Toxin and Related Neurological Disorders
- Neurological disorders and treatments
- Cerebral Venous Sinus Thrombosis
- Psychosomatic Disorders and Their Treatments
- Long-Term Effects of COVID-19
- Neurosurgical Procedures and Complications
- Migraine and Headache Studies
- Mitochondrial Function and Pathology
- Muscle Physiology and Disorders
- Neurology and Historical Studies
- Musculoskeletal Disorders and Rehabilitation
- Spinal Hematomas and Complications
- Transcranial Magnetic Stimulation Studies
- Monoclonal and Polyclonal Antibodies Research
- Ophthalmology and Eye Disorders
- Cerebrovascular and genetic disorders
- Cancer Immunotherapy and Biomarkers
- Connective tissue disorders research
- Healthcare and Venom Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Plant-based Medicinal Research
National Hospital for Neurology and Neurosurgery
2013-2024
University College London
2013-2024
University College London Hospitals NHS Foundation Trust
2019-2024
Imperial College London
2013-2015
Mayo Clinic in Arizona
2010
Mayo Clinic
2009
Federico II University Hospital
2006
Background New daily persistent headache (NDPH) is a poorly understood disorder which often begins after viral infection and has been hypothesised to have an immune basis. Several studies found differences in peripheral serum cytokine levels between healthy controls patients with other primary disorders such as migraine. We sought measure of cytokines chemokines NDPH, chronic migraine (CM), controls, identify any changes could be biomarkers inflammation NDPH. Methods performed observational...
<h3>Objective</h3> To test the hypothesis that Joint hypermobility and autonomic dysfunction are over-expressed within neurodevelopmental disorders. is a widespread poorly recognized connective tissue condition with affected individuals overrepresented among panic anxiety disorders, irritable bowel syndrome, fibromyalgia, chronic fatigue. The relevance of to neuropsychiatric disorders developmental origin currently unknown, despite anecdotal case reports clinical suspicion link. Autonomic...
Abstract Background and Purpose Pure autonomic failure (PAF) presents primarily as cardiovascular may phenoconvert to other neurodegenerative disorders. However, the involvement of functions has been poorly evaluated. This study aims characterize genitourinary bowel dysfunction explore their relationship with dysfunction. Methods patients underwent testing an assessment pelvic using urinary, sexual symptoms questionnaires a bladder diary. Demographic, clinical features related medical...
To assess the knowledge, attitudes and practices of healthcare professionals regarding diagnosis management spontaneous intracranial hypotension (SIH).We performed a cross-sectional, web-based survey multiple professional groups in UK from June to August 2021. There were 227 respondents survey, including 62 general practitioners, 39 emergency medicine physicians, 38 neurologists, 35 radiologists, 20 neurosurgeons, 18 anaesthetists 15 headache nurse specialists. The majority at consultant...
Abstract Background Fibromyalgia is characterised by chronic widespread pain. Quality of life further reduced autonomic and cognitive symptoms, including subjective ‘brain-fog’ dissociative experiences. Although an association with joint hypermobility suggests variant connective tissue a factor in both fibromyalgia dysautonomia, the mechanisms underlying neuropsychiatric symptoms are poorly understood. Methods 21 patients healthy controls were assessed for experiences, interoceptive...
<h3>Introduction</h3> Post-COVID syndrome (PCS) is a well-recognised and frequently debilitating constellation of signs symptoms that persist for at least 12 weeks after COVID-19 infection. Cardiovascular symptoms, particularly those associated with inappropriate sinus tachycardia (IST), are common can include palpitations breathlessness, which impede patients in their daily tasks be difficult to manage. Previous research has suggested dysautonomia, dysfunction the autonomic nervous system,...
The aim of this study was to compare cardiovascular autonomic function Hyperadrenergic PoTS, defined as a plasma norepinephrine >; 600 ng/mol during orthostasis, PoTS due other causes. Clinical test results were reviewed. 50 patients identified; 18 with PoTS. Plasma higher while upright (383 ± 99 vs 726 112 ng/mol, p<0.05) and supine (233 58 422 128 in There no differences heart rate or blood pressure cold pressor challenge, mental stress, isometric exercise, deep breathing short‐term...
Introduction The profile of neurological disorders post-SARS-CoV-2 remains unclear. We describe obser- vations from a SARS-CoV-2 neurology clinic established to meet demand. Methods A retrospective case-note review consecutive patients attending SARS-CoV2 over 6-month period was conducted. Demographics, clinical features, medications and inves- tigation results were collected. Results There 122 included (78 female: 44 male, median age years); all met WHO criteria for probable or confirmed...
Introduction Orthostatic hypotension (OH) and supine hypertension (SH) are prevalent in alpha-synucle- inopathies, posing a therapeutic dilemma as OH treatment may worsen SH. We aimed to characterise SH pure autonomic failure (PAF), multiple system atrophy (MSA), Lewy body disorders (LBD: Parkinson’s disease Dementia with bodies). Methods 166 patients (72 PAF, 59 MSA, 35 LBD) underwent cardiovascular testing 24hr- ambulatory blood pressure monitoring (24hr-ABPM). Demographic, clinical...
Post-coronavirus disease 19 (COVID-19) syndrome has substantial health and economic implications. It is multi-systemic, with prevalent autonomic symptoms. Understanding presentations potential causes may help guide treatment strategies recovery. All patients a suspected or confirmed history of COVID-19 infection who underwent testing between May 2020 October 2021 were reviewed retrospectively. We evaluated 62 (20 male, 42 female, mean age 41.38 ±11.52). was PCR in 15 (26%), five (8%)...
Introduction Cardiovascular autonomic failure is the hallmark finding in Pure (PAF) however other functions are likely to be affected. This study aims characterise genitourinary dysfunction PAF patients and explore their relationship with cardiovascular dysfunction. Methods who underwent testing completed self-administered questionnaires evaluating urinary sexual symptoms a 3-day bladder diary measuring fluid intake urine output. Demographic, clinical features, disease duration related...