A5024190836- Multiple Sclerosis Research Studies
- Heparin-Induced Thrombocytopenia and Thrombosis
- Venous Thromboembolism Diagnosis and Management
- Platelet Disorders and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Neuroscience of respiration and sleep
- Obstructive Sleep Apnea Research
- Colorectal Cancer Screening and Detection
- Prostate Cancer Diagnosis and Treatment
- Cerebral Venous Sinus Thrombosis
- Autoimmune and Inflammatory Disorders Research
- Biosimilars and Bioanalytical Methods
- Respiratory Support and Mechanisms
- Cell Image Analysis Techniques
- Epilepsy research and treatment
- Cytokine Signaling Pathways and Interactions
- Viral Infections and Immunology Research
- CAR-T cell therapy research
- Botulinum Toxin and Related Neurological Disorders
- Acute Lymphoblastic Leukemia research
- Complement system in diseases
- Prostate Cancer Treatment and Research
- Long-Term Effects of COVID-19
- Renal Diseases and Glomerulopathies
- Family Support in Illness
National Hospital for Neurology and Neurosurgery
2022-2024
University College London
2022-2024
Queen Mary University of London
2023-2024
King's College Hospital NHS Foundation Trust
2021-2023
King's College Hospital
2022
Mater Dei Hospital
2017
Introduction There remains a high unmet need for disease-modifying therapies that can impact disability progression in secondary progressive multiple sclerosis (SPMS). Following positive results of the phase 2 MS-STAT study, MS-STAT2 3 trial will evaluate efficacy and cost-effectiveness repurposed high-dose simvastatin slowing SPMS. Methods analysis be multicentre, randomised, placebo-controlled, double-blind participants aged between 25 65 (inclusive) who have SPMS with an Expanded...
Continuous positive airway pressure (CPAP) is the standard treatment for obstructive sleep apnoea (OSA), with limited data about prevalence of respiratory infections and microbial colonization in these patients.The aim this study was to determine if CPAP use associated identify organisms that colonize or infect patients.A retrospective, case-controlled patients diagnosed OSA carried out. 137 were recruited interviewed using a questionnaire. A nasal swab taken from each patient. Patients...
Vaccination strategies have been at the forefront of controlling COVID-19 pandemic. An association between vaccine-induced immune thrombotic thrombocytopenia (VITT) and one these vaccines, ChAdOx1 nCov-19 vaccine, is now recognized. The purpose this study was to investigate frequency location thrombosis in each vascular system using CT, MRI, US identify additional sites thrombus a United Kingdom-wide sample patients with confirmed VITT. Thirty-two radiology centers identified through...
A 50-year-old man with known multidrug resistant coexistent focal and generalised epilepsy was commenced on ethosuximide, normalisation of his electroencephalogram cessation absence seizures. Within 3 weeks, he developed a rapidly worsening paranoid psychosis visual olfactory hallucinations. month after the ethosuximide concurrent treatment olanzapine, resolved permitted reinitiation at lower dose without recurrence psychotic symptoms.
Paroxysmal nocturnal hemoglobinuria (PNH) is characterized by hemolysis and thrombosis associated with significant morbidity mortality. Although complement inhibitors have significantly changed the outcomes in PNH patients, breakthrough (BTH) may still occur as a response to stress factors such pregnancy, surgery, infections. Despite well-described association between bacterial infections little known about effect of respiratory viruses on triggering hemolytic episodes. This first study, our...
Abstract Promising blood-based biomarkers of neuropathology have emerged with potential for therapeutic development and disease monitoring. However, these tools will require specialist tertiary services integration into clinical management. Remote sampling biomarker assessment could ease the burden in-person visits such tests allow frequent sampling. Here we evaluated a capillary finger-prick collection remote quantification blood neurofilament light (NfL), common evident in various...
Background: A rare prothrombotic syndrome, termed vaccine-induced immune thrombotic thrombocytopaenia (VITT) has been described following administration of the first ChAdOx1 nCov-19 (Astrazeneca) vaccine. Patients present with thrombosis in multiple sites. Targeted imaging is key to diagnosing thrombus organ or system localising symptoms, and early accurate identification extent multiplicity occult thromboses other vascular systems required best manage these patients. Methods: We performed a...
Post-coronavirus disease 19 (COVID-19) syndrome has substantial health and economic implications. It is multi-systemic, with prevalent autonomic symptoms. Understanding presentations potential causes may help guide treatment strategies recovery. All patients a suspected or confirmed history of COVID-19 infection who underwent testing between May 2020 October 2021 were reviewed retrospectively. We evaluated 62 (20 male, 42 female, mean age 41.38 ±11.52). was PCR in 15 (26%), five (8%)...