A5023311400- Multiple Sclerosis Research Studies
- Adolescent and Pediatric Healthcare
- Amyotrophic Lateral Sclerosis Research
- Mental Health and Patient Involvement
- Rheumatoid Arthritis Research and Therapies
- Childhood Cancer Survivors' Quality of Life
- Mycobacterium research and diagnosis
- Advances in Oncology and Radiotherapy
- Powdery Mildew Fungal Diseases
- Metabolism and Genetic Disorders
- Full-Duplex Wireless Communications
- Biochemical and Molecular Research
- Autoimmune and Inflammatory Disorders Research
- Systemic Sclerosis and Related Diseases
- Cytokine Signaling Pathways and Interactions
- Polyomavirus and related diseases
- Chronic Disease Management Strategies
- Neonatal Health and Biochemistry
- Plant Virus Research Studies
- Coaching Methods and Impact
Torbay and South Devon NHS Foundation Trust
2020-2025
University of Plymouth
2024-2025
Torbay Hospital
2025
Derriford Hospital
2012
Lifestyle and environmental factors are key determinants in disease causality progression neurological conditions, including multiple sclerosis (MS). Lack of exercise, poor diet, tobacco smoking, excessive alcohol intake, social health, concomitant medications, sleep comorbidities can exacerbate MS pathological processes by impacting brain health depleting reserves, resulting more rapid worsening. In addition to using disease-modifying therapies alter the course, therapeutic strategies...
The negative impact of smoking in multiple sclerosis is well established; however, there much less evidence as to whether cessation beneficial progression sclerosis. Adults with registered on the United Kingdom Multiple Sclerosis Register (2011-20) formed this retrospective and prospective cohort study. Primary outcomes were changes three patient-reported outcomes: normalized Physical Impact Scale (MSIS-29-Phys), Walking (MSWS-12) Hospital Anxiety Depression (HADS). Time event clinically...
Background Innovations are essential to meet the needs of people with MS (PwMS), particularly in addressing delays diagnosis and treatment, supporting patient self-management. Objectives To evaluate real-world use outcomes digital technologies holistic management strategies for at a UK Centre. Methods Digital tools PwMS included Patients Know Best (a personal health record) CONNECTPlus ® (an educational app). Tools healthcare professionals Infoflex clinical database MSProDiscuss assessing...
Introduction There remains a high unmet need for disease-modifying therapies that can impact disability progression in secondary progressive multiple sclerosis (SPMS). Following positive results of the phase 2 MS-STAT study, MS-STAT2 3 trial will evaluate efficacy and cost-effectiveness repurposed high-dose simvastatin slowing SPMS. Methods analysis be multicentre, randomised, placebo-controlled, double-blind participants aged between 25 65 (inclusive) who have SPMS with an Expanded...
Autosomal recessive disorders affecting pyridoxine (vitamin B6) metabolism are a rare but well-recognized cause of neonatal seizures. Antiquitin deficiency, caused by mutations in ALDH7A1, is disorder the lysine degradation pathway causing accumulation an intermediate that complexes with pyridoxal phosphate. Reports long-term follow-up pyridoxine-dependent seizures (PDS) remain scarce and prognostic information varied. We report case PDS 47-year-old lady who originally presented shortly...
Registries have the potential to tackle some of current limitations in determining long-term impact multiple sclerosis. Online assessments using patient-reported outcomes can streamline follow-up enabling large-scale, long-term, cost-effective, home-based, and patient-focused data collection. However, registry are sparsely sampled sensitivity relative clinician-reported scales is unknown, making it hard fully leverage their unique scope scale derive insights. This retrospective prospective...
To test the feasibility of a targeted peer coaching intervention on health and well-being people with long-term conditions low activation attending outpatient clinics at UK National Health Service (NHS) Trust.
A 36-year-old woman with relapsing remitting multiple sclerosis (MS) presented right-sided spasms, focal seizures and neuropsychiatric symptoms 10 months after her first course of alemtuzumab. Magnetic resonance imaging (MRI) brain revealed foci T2 hyperintensity. Subsequent blood cerebrospinal fluid (CSF) testing for progressive multifocal leukoencephalopathy (PML), vasculitis infective causes was negative. biopsy performed, revealing a prominent perivascular inflammatory infiltrate immune...
Introduction Patients with low levels of knowledge, skills and confidence to manage their health well-being (activation) are more likely have unmet needs, delay seeking healthcare need emergency care. National Health Service England estimates that this may be applicable 25%–40% patients long-term conditions. Volunteer peer coaching support people increase level activation. This form intervention particularly effective for Methods analysis single site, two-arm randomised controlled trial has...
OBJECTIVE: To determine the impact of smoking cessation on disease progression in Multiple SclerosisDESIGN: Retrospective and prospective cohort registry studies.SETTING: UK-wide, community-based.PARTICIPANTS: Adults with confirmed multiple sclerosis (MS) registered United Kingdom MS Register. Data was collected between 2011 2020.MAIN OUTCOME MEASURE: 4-year parallel group primary outcomes were changes 3 patient reported (PROs): normalised Physical Impact Scale (MSIS-29-Phys), Walking...