A5069291697- Multiple Sclerosis Research Studies
- Health Systems, Economic Evaluations, Quality of Life
- Neurogenesis and neuroplasticity mechanisms
- Health disparities and outcomes
- Systemic Lupus Erythematosus Research
- Polyomavirus and related diseases
- Viral Infections and Vectors
- Cardiac Health and Mental Health
- Peripheral Neuropathies and Disorders
- Amyotrophic Lateral Sclerosis Research
- Salivary Gland Disorders and Functions
- Hallucinations in medical conditions
- Fibromyalgia and Chronic Fatigue Syndrome Research
- thermodynamics and calorimetric analyses
- Brain Metastases and Treatment
- Dementia and Cognitive Impairment Research
- Health and Well-being Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Head and Neck Surgical Oncology
- Vector-borne infectious diseases
- Acute Lymphoblastic Leukemia research
- Viral Infections and Immunology Research
- Meningioma and schwannoma management
- Otitis Media and Relapsing Polychondritis
- Mosquito-borne diseases and control
University of Liverpool
2012-2024
Walton Centre
2012-2024
University of Oxford
2006-2010
Northern General Hospital
2001
University of Sheffield
1998
Japanese encephalitis virus is a mosquito-borne flavivirus that causes approximately 10000 deaths annually in Asia. After brief viraemia, the enters central nervous system, but means of crossing blood-brain barrier uncertain. We used routine histological staining, immunohistology and electron microscopy to examine brain material from four fatal human cases, made comparisons with mouse model. In there was oedema, perivascular inflammation, haemorrhage, microglial nodules acellular necrotic...
To compare very short scales for screening depression with longer, widely used scales.Eighty-seven patients over the age of 60 who were admitted to rehabilitation wards or attending a day facility at British teaching hospital screened using 1-item mental health inventory, and 4-item, 15-item 30-item geriatric scales. The sensitivity, specificity, areas under receiver operating characteristic curves compared, diagnostic criteria research ICD-10 providing criterion diagnosis depressive...
Lifestyle and environmental factors are key determinants in disease causality progression neurological conditions, including multiple sclerosis (MS). Lack of exercise, poor diet, tobacco smoking, excessive alcohol intake, social health, concomitant medications, sleep comorbidities can exacerbate MS pathological processes by impacting brain health depleting reserves, resulting more rapid worsening. In addition to using disease-modifying therapies alter the course, therapeutic strategies...
The use of immunohistochemical methods has led to a new understanding the prevalence and significance cortical lesions in multiple sclerosis but these have not yet been formally described an animal model. In this study we set out techniques identify describe marmosets with experimental autoimmune encephalomyelitis (EAE). Using antibodies proteolipid protein (PLP), found total 70 11 tissue blocks from 6 animals. These were subdivided into leucocortical (40), intracortical (12) subpial (18)....
Abstract Purpose Symptoms of Multiple Sclerosis (MS) differentially impact upon quality life (QoL) and a comprehensive measure is required for use in observational interventional studies. This study examines the abbreviated World Health Organisation Quality Life tool (WHOQOL-BREF) which was designed to be used as broad QoL across different cultures diseases. Methods Data were collected from 3186 subjects part TONiC MS examined with systematic, iterative approach using Rasch analysis...
Background: Degenerative features, such as neuronal, glial, synaptic and axonal loss, have been identified in neocortical other grey matter structures patients with multiple sclerosis, but mechanisms for neurodegeneration are unclear. Cortical demyelinating lesions a potential cause of this degeneration, the pathological clinical significance these is uncertain they remain difficult to identify study vivo. In we aimed describe quantify cellular subcellular pathology cortex myelin...
The World Health Organisation quality of life abbreviated scale (WHOQOL-BREF) was developed as a measure across 4 separate health domains; physical health, psychological, social relationships and environment. This study evaluated the validity WHOQOL-BREF in post-polio syndrome by testing it for fit against Rasch model.The posted to 319 volunteers, 271 (85%) completed with mean age 66.7 years (standard deviation 8.15); 64% were female. domain fitted model (χ2 p = 0.19) but reliability low (α...
<h3>Background</h3> Visual hallucinations of Charles Bonnet syndrome (CBS) secondary to visual deprivation occur in 11–15% elderly patients with acquired impairment. It is increasingly recognised that there an auditory form CBS consisting musical hearing loss. Here we present two cases CBS. Case 1: An 82 year old man age related macular degeneration and deafness presented a 2 history transient which met proposed diagnostic criteria for 1 retained insight. 2: 85 lady was referred by...
Objective To compare very short scales for screening depression with longer, widely used scales. Methods Eighty-seven patients over the age of 60 who were admitted to rehabilitation wards or attending a day facility at British teaching hospital screened using 1-item mental health inventory, and 4-item, 15-item 30-item geriatric The sensitivity, specificity, areas under receiver operating characteristic curves compared, diagnostic criteria research ICD-10 providing criterion diagnosis...
<h3>Case</h3> A 42 year old lady with a previous history of Raynaud9s syndrome presented right optic neuritis and hemiparesis. MRI showed widespread T2 hyperintensities in the deep white matter, corpus callosum, posterior fossa suggestive demyelination. LP revealed type 4 oligoclonal bands. Serum pANCA MPO were transiently elevated. She followed relapsing remitting course new facial numbness, left hemiparesis inflammatory lesions seen on imaging over month period. Based working diagnosis...
A 59-year-old woman provided a 3-month history of decreased hearing in her right ear. One month later, she developed complete right-sided ptosis and progressive dysarthria. On examination, there was third cranial nerve palsy with mydriasis, sensorineural loss left lower motor neurone facial weakness. There were signs brachial plexopathy (with weakness, wasting partial hypoaesthesia the arm), unchanged since these features had following radiotherapy for local recurrence breast cancer 10 years...
This study investigated the effects of relapses and levels disability on resource use in a multidisciplinary MS clinic. Data were collected over 12-month period number clinic visits, relapse rate, disease modifying therapies (DMTs), team, treatment individual symptoms. 41/427 patients had relapse. Relapsing lower but more visits (mean 4.63 vs 2.79, p<0.001), likely to see specialist nurse (82% 62% p=0.019), physiotherapist (65.9% 46.1%, p=0.021) orthoptist (41.5% 22.3% p=0.001). receive...