A5045086952- Particle physics theoretical and experimental studies
- Quantum Chromodynamics and Particle Interactions
- High-Energy Particle Collisions Research
- Anesthesia and Sedative Agents
- Neutrino Physics Research
- Anesthesia and Neurotoxicity Research
- Nuclear physics research studies
- Dark Matter and Cosmic Phenomena
- Advanced NMR Techniques and Applications
- Atomic and Subatomic Physics Research
- Muon and positron interactions and applications
- Particle Detector Development and Performance
- Peroxisome Proliferator-Activated Receptors
- Traumatic Brain Injury and Neurovascular Disturbances
- Respiratory Support and Mechanisms
- Superconducting Materials and Applications
- Radiation Detection and Scintillator Technologies
- Neuroscience and Neuropharmacology Research
- Lipid metabolism and biosynthesis
- Cardiac Arrest and Resuscitation
- Particle Accelerators and Free-Electron Lasers
- Odor and Emission Control Technologies
- Cardiac, Anesthesia and Surgical Outcomes
- Scientific Research and Discoveries
- Astrophysics and Cosmic Phenomena
Argonne National Laboratory
2008-2024
Johannes Kepler University of Linz
2020
High Energy Accelerator Research Organization
2019
Thames Water (United Kingdom)
2000-2019
University of Washington
1978-2015
University of Illinois Urbana-Champaign
2007-2015
United States Department of Energy
2015
Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Frascati
2015
University of Illinois System
2011-2013
Forschungszentrum Jülich
2001-2008
The blood coagulation system of 66 consecutive patients undergoing liver transplantations was monitored by thrombelastograph and analytic profile. A poor preoperative state, decrease in levels factors, progressive fibrinolysis, whole clot lysis were observed during the preanhepatic anhepatic stages surgery. further general factors platelets, activation abrupt V VIII occurred before with reperfusion homograft. Recovery coagulability began 30-60 min after graft liver, had returned toward...
The potency and anesthetic state produced by nitrous oxide alone were investigated in order to clarify its contribution the effect of other agents. Seven volunteers anesthetized with 1.55 atm absolute N2O a pressure chamber displayed muscle rigidity jerking movements, labored rapid breathing, sweating, dilated pupils. At 1.1 N2O, relaxation quiescence occurred, sweating ceased, pupil size decreased. Determination MAC (using tetanic electrical impulses as noxious stimulus) mean value 1.04 +/-...
Japanese encephalitis virus (JEV), the mosquito-borne flavivirus, annually causes an estimated 35,000-50,000 cases and 10,000-15,000 deaths in Asia, there is no antiviral treatment. The role played by immune response determining outcome of human infection with JEV poorly understood, although, animal models flavivirus encephalitis, unregulated proinflammatory cytokine responses can be detrimental.We studied innate, cellular, humoral 118 patients infected JEV, whom 13 (11%) died.Levels...
ACUTE carbon monoxide poisoning accounts for approximately 3,500 accidental or suicidal deaths per year in the United States. Many are preventable by medical management based on physiologic understanding. <h3>Pathophysiology</h3> Carbon and its mechanism have been known since Claude Bernard reported 1857 that this gas caused death hypoxia, consequent reversible combination with hemoglobin.<sup>1</sup>The equilibrium reactions were well described Haldane 1895.<sup>2</sup>Excellent reviews...
Recent positron emission tomography (PET) studies have demonstrated areas of pain processing in the human brain.Given inhibitory effects opioids on neuronal activity, we predicted that fentanyl's analgesic would be associated with suppression pain-evoked responses these distinct brain areas. To test this, PET was used to measure cerebral blood flow responses, as reflections regional painful and nonpainful thermal stimuli both absence presence fentanyl humans. During each scan nine healthy...
Positron emission tomography (PET) is a noninvasive imaging technique that can be used to observe drug actions on human brain in vivo.We used15 O-water PET scanning six volunteers examine the effects regional cerebral activity as reflected by blood flow (rCBF) of small intravenous bolus fentanyl. rCBF was compared between scans obtained after fentanyl or placebo using three separate statistical criteria including pixel-by-pixel t statistic; significance stringently defined at P values <...
Japanese encephalitis virus is a mosquito-borne flavivirus that causes approximately 10000 deaths annually in Asia. After brief viraemia, the enters central nervous system, but means of crossing blood-brain barrier uncertain. We used routine histological staining, immunohistology and electron microscopy to examine brain material from four fatal human cases, made comparisons with mouse model. In there was oedema, perivascular inflammation, haemorrhage, microglial nodules acellular necrotic...
The incidence of hypoxemia in the immediate postoperative period was determined using a pulse oximeter for continuous monitoring arterial oxygen saturation (Sao2) 95 ASA class I or II adult patients breathing room air during their transfer from operating to recovery room. Hypoxemia defined as 90% Sao2 (arterial partial pressure (PaO2) ≅ 58 mm Hg). Severe 85% (PaO2 50 occurred 33 (35%) patients; severe 11 (12%). Postoperative did not correlate significantly with anesthetic agent, age,...
Department of Anesthesiology and Critical Care Medicine, University Pittsburgh School Pittsburgh, Pennsylvania
Cardiovascular function, serum ionized calcium (Ca+2), and citrate were measured intraoperatively in patients (n = 9) undergoing orthotopic hepatic homotransplantation. Serum increased 20-fold (P less than 0.0006) following transfusion of citrated blood products the absence a functional liver. decreased 0.003) with concomitant decreases cardiac index 0.005), stroke 0.004), left ventricular work 0.001). Hemodynamic depression ionic hypocalcemia reversed administration CaCl2. In contrast to...
We report a measurement of the positive muon lifetime to precision 1.0 ppm; it is most precise particle ever measured. The experiment used time-structured, low-energy beam and segmented plastic scintillator array record more than 2×1012 decays. Two different stopping target configurations were employed in independent data-taking periods. combined results give τμ+(MuLan)=2 196 980.3(2.2) ps, 15 times as any previous experiment. gives value for Fermi constant: GF(MuLan)=1.166 378 8(7)×10−5...
Total and differential cross sections for the dp→He3η reaction have been measured near threshold He3 center-of-mass momenta in range from 17.1 MeV/c to 87.5 MeV/c. The data were taken during a slow ramping of COSY internal deuteron beam scattered on proton target detecting ejectiles with COSY-11 facility. forward–backward asymmetries deviate clearly zero above 50 indicating presence higher partial waves final state. Below fit state enhancement factor total results He3–η scattering length...
We present a detailed report of the method, setup, analysis and results precision measurement positive muon lifetime. The experiment was conducted at Paul Scherrer Institute using time-structured, nearly 100%-polarized, surface beam segmented, fast-timing, plastic scintillator array. employed two target arrangements; magnetized ferromagnetic with ~4 kG internal magnetic field crystal quartz in 130 G external field. Approximately 1.6 x 10^{12} positrons were accumulated together data yield...
Thirteen elderly male patients with measured cognitive deficits were treated 30 intermittent exposures to 100 per cent oxygen at 2.5 atmospheres absolute. Five controls, each exposed the same time and manner as a paired experimental patient, breathed low mixture that maintained essentially normal alveolar tension despite increased ambient pressure. Arterial samples for blood gas determinations obtained from patient during one of early hyperbaric exposures. Analysis showed expected large...
We present the results from first axion-like particle search conducted using a dish antenna. The experiment was at room temperature and sensitive to particles in $44-52\,\mu\mathrm{eV}$ range ($10.7 - 12.5\,\mathrm{GHz}$). novel antenna geometry proposed by BREAD collaboration previously used conduct dark photon same mass range. To allow for sensitivity, placed $3.9\,\mathrm{T}$ solenoid magnet Argonne National Laboratory. In presence of magnetic field, matter converts photons conductive...
Recent positron emission tomography (PET) studies have demonstrated areas of pain processing in the human brain.Given inhibitory effects opioids on neuronal activity, we predicted that fentanyl's analgesic would be associated with suppression pain-evoked responses these distinct brain areas. To test this, PET was used to measure cerebral blood flow responses, as reflections regional painful and nonpainful thermal stimuli both absence presence fentanyl humans. During each scan nine healthy...
The rate of nuclear muon capture by the proton has been measured using a new technique based on time projection chamber operating in ultraclean, deuterium-depleted hydrogen gas, which is key to avoiding uncertainties from muonic molecule formation. hyperfine singlet ground state μp atom was obtained difference between μ− disappearance and world average for μ+ decay rate, yielding ΛS=725.0±17.4 s−1, induced pseudoscalar coupling nucleon, gP(q2=−0.88m2μ)=7.3±1.1, extracted.Received 16 April...
Using tests of complex reaction time and immediate recall (digit span), the authors could not demonstrate that trace concentrations halothane (to 0.02 per cent, or 200 parts million) plus nitrous oxide (0.002 cent 0.05 respectively) alone (0.4 cent) affected mental function male volunteers. However, subanesthetic both (20 to 30 (0.2 did impair function.
The MuCap experiment at the Paul Scherrer Institute has measured rate L_S of muon capture from singlet state muonic hydrogen atom to a precision 1%. A beam was stopped in time projection chamber filled with 10-bar, ultra-pure gas. Cylindrical wire chambers and segmented scintillator barrel detected electrons decay. is determined difference between mu- disappearance free decay rate. result based on analysis 1.2 10^10 decays, which we extract = (714.9 +- 5.4(stat) 5.1(syst)) s^-1 derive...
A high statistics measurement of the pp --> ppeta reaction at an excess energy Q = 15.5 MeV has been performed internal beam facility COSY-11. The stochastically cooled proton and used detection system allowed to determine momenta outgoing protons with a precision 4 MeV/c (sigma) in center-of-mass frame. determination four-momentum vectors both derive complete kinematical information ppeta-system. An unexpectedly large enhancement occupation density regions low proton-eta relative is...
The administration of naloxone 2, 10, 50, or 250 mg/kg intravenously did not alter halothane requirement (MAC) in Sprague-Dawley rats (12 per group). Two convulsed when given 50 while anesthetized with halothane. In a separate group awake rats, seven nine animals naloxone, 100 mg/kg. It is concluded that any effect on anesthetic must be small (not significant our study), and if an exists it the result nonspecific analeptic action rather than specific at opiate receptors.