A5103177964- Organ Transplantation Techniques and Outcomes
- Esophageal Cancer Research and Treatment
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Liver Disease and Transplantation
- Esophageal and GI Pathology
- Alzheimer's disease research and treatments
- Neonatal and fetal brain pathology
- Fetal and Pediatric Neurological Disorders
- Advanced Neuroimaging Techniques and Applications
- Trauma and Emergency Care Studies
- Glioma Diagnosis and Treatment
- Epilepsy research and treatment
- Advanced MRI Techniques and Applications
- Emergency and Acute Care Studies
- Acute Ischemic Stroke Management
- Glycosylation and Glycoproteins Research
- Protein Structure and Dynamics
- Liver Disease Diagnosis and Treatment
- Brain Tumor Detection and Classification
- Gastric Cancer Management and Outcomes
- Drug Transport and Resistance Mechanisms
- Electronic Health Records Systems
- Proteoglycans and glycosaminoglycans research
- Healthcare Technology and Patient Monitoring
- Trauma, Hemostasis, Coagulopathy, Resuscitation
Cincinnati Children's Hospital Medical Center
2024
Nationwide Children's Hospital
2024
University of Southern California
2024
Case Western Reserve University
2022-2024
University Hospitals of Cleveland
2022-2023
University of Manitoba
2020
University of Alberta
2020
Stanford University
2020
University of Calgary
2020
Rocky Vista University
2020
The blood coagulation system of 66 consecutive patients undergoing liver transplantations was monitored by thrombelastograph and analytic profile. A poor preoperative state, decrease in levels factors, progressive fibrinolysis, whole clot lysis were observed during the preanhepatic anhepatic stages surgery. further general factors platelets, activation abrupt V VIII occurred before with reperfusion homograft. Recovery coagulability began 30-60 min after graft liver, had returned toward...
A venous bypass technique (BP) that does not require the use of systemic anticoagulation is used routinely at our institution in all adult patients during anhepatic phase liver transplantation (LT). Complete cardiopulmonary profiles were obtained a subset 28 consecutive cases. During while on bypass, mean arterial pressure, central and pulmonary wedge pressure maintained prehepatectomy levels. Oxygen consumption fell secondary to decrease temperature removal liver. Consequently, cardiac...
Cardiovascular function, serum ionized calcium (Ca+2), and citrate were measured intraoperatively in patients (n = 9) undergoing orthotopic hepatic homotransplantation. Serum increased 20-fold (P less than 0.0006) following transfusion of citrated blood products the absence a functional liver. decreased 0.003) with concomitant decreases cardiac index 0.005), stroke 0.004), left ventricular work 0.001). Hemodynamic depression ionic hypocalcemia reversed administration CaCl2. In contrast to...
The anhepatic phase of an orthotopic: liver transplantation procedure occun when the surgeon has removed native (along with intrahepatic: portion vena cava) and is involved in sewing donor organ.During this interval.the inferior cava c:ross-clamped at diaphragm a point just above entry renal veins.The result complete interruption venous return from cava.u evident sudden decrease both central pulmonary arterial wedge pressures, resulting . profound reduction cardiac:The portal vein also...
Reported incidence of extravertebral cement leakage after vertebroplasty varies widely across studies.To retrospectively compare the relative detection rates noted under intra-procedural fluoroscopic surveillance, postprocedure plain radiographs, and computed tomography (CT) in a cohort patients undergoing vertebroplasty.With IRB approval, we identified 181 with 277 levels treated percutaneous among total 1255 between 1999 2010 who had subsequently undergone CT examination that included...
Background: A noninvasive and sensitive imaging tool is needed to assess the fast-evolving baby brain. However, using MRI study non-sedated babies faces roadblocks, including high scan failure rates due subjects motion lack of quantitative measures for assessing potential developmental delays. This feasibility explores whether MR Fingerprinting scans can provide motion-robust brain tissue measurements infants with prenatal opioid exposure, presenting a viable alternative clinical scans....
Light chain amyloidosis (AL amyloidosis) is a haematological disorder in which clonal population of B cells expands and secretes enormous amounts the immunoglobulin light protein. These chains misfold aggregate into amyloid fibrils, leading to organ dysfunction death. We have studied vitro fibril formation kinetics two patient-derived variable domain proteins, designated AL-09 AL-103, response changes solution conditions. Both proteins are members κI O18:O8 germline therefore highly similar...
Total body opacification is the radiological phenomenon in which, after intravenous injection, contrast agent opacifies structures of proportion to their blood supply. Avascular lesions can thus be rendered radiologically visible as lucencies newly contrasting with surrounding opacified structures. Appreciation total effect widely useful diagnostic radiology, especially delineation and characterization neonatal abdominal masses.
. Purpose To evaluate nn-Unet-based segmentation models for automated delineation of medulloblastoma (MB) tumors on multi-institutional MRI scans. Materials and Methods This retrospective study included 78 pediatric patients (52 male, 26 female), with ages ranging from 2-18 years, MB three different sites (28 Hospital A, 18 B, 32 C), who had data clinical protocols (gadolinium-enhanced T1-weighted, T2-weighted, FLAIR) available. The scans were retrospectively collected the year 2000 until...
We explore the possibility of using diffusion tensor imaging (DTI) and neurite orientation dispersion density (NODDI) to discern microstructural abnormalities in hippocampus indicative mesial temporal sclerosis (MTS) at subfield level.We analyzed data from 57 patients with refractory epilepsy who previously underwent 3.0-T magnetic resonance (MRI) including DTI as a standard part presurgical workup. collected information about each subject's seizure semiology, conventional...
More extensive resection for esophageal cancer has been reported to improve survival in several series. We compared results from an unselected consecutive cohort of patients undergoing radical esophagectomy, including removal all periesophageal tissue with a 2-field abdominal and mediastinal lymphadenectomy gastroesophageal malignancy. A prospective electronic database was reviewed malignancy open esophagectomy between 1991 2004. Data were analyzed on SPSS file (version 12.0, Chicago, IL,...
The 5 min high resolution MRF scans coupled with low-rank iterative reconstruction successfully generated perfectly co-registered T1, T2 maps, synthetic MR contrast images, R1R2 and myelin water fraction maps. Image Quality Assessment analysis three pediatric neuroradiologists found that based T1w T2w images quality were superior in to MRI (p<.0001) lower image artifacts the as compared standard of care MRI. demonstrated better visualization clinical T1w, improved tissue structure images.
Current distal esophageal and gastroesophageal junction (GEJ) cancer radiotherapy guidelines for regional lymph node clinical target volume (CTV) include elective coverage of part retrocrural nodes at the level celiac axis. Recognizing are not routinely dissected during esophagectomy, there is currently a knowledge gap in prevalence metastases how inclusion CTV design affects radiation dose to organs-at-risk. We aimed better define spread GEJ quantify impact critical organs. Retrospective...
917 The natural history of PSC recurrence following orthotopic liver transplantation (OLTx) has not been fully documented. Methods: Over a period 16 years, 303 patients received total 380 allografts for PSC. M:F ratio was 2.2:1. Mean age 44±12 years recipients and 30±15 donors. Primary immunosuppression (I) cyclosporin in 54% tacrolimus 46% the grafts. cold ischemia time (CIT) 11.2±4.2 hours. Follow-up evaluation included serial biopsies cholangiographic studies mostly all recipients....
With the increase in networked medical devices, healthcare institutions are challenged with balancing security and integrity of information technology (IT) network integrating that data available from devices so it may be more readily disseminated to disparate systems. Carilion Clinic Health System—an independent delivery (IDN) seven hospitals than 200 ambulatory clinics departments—has developed a policy process for addressing secure connectivity its inventory. Using combination industry...