A5101753493- Mental Health Research Topics
- Child and Adolescent Psychosocial and Emotional Development
- COVID-19 and Mental Health
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Bipolar Disorder and Treatment
- Treatment of Major Depression
- Eating Disorders and Behaviors
- Mental Health Treatment and Access
- Genetic Associations and Epidemiology
- Obesity, Physical Activity, Diet
- Force Microscopy Techniques and Applications
- Immune Cell Function and Interaction
- Health and Well-being Studies
- Health and Wellbeing Research
- IL-33, ST2, and ILC Pathways
- Genetics and Neurodevelopmental Disorders
- Psychosomatic Disorders and Their Treatments
- Diamond and Carbon-based Materials Research
- Mechanical and Optical Resonators
- Cognitive Abilities and Testing
- Posttraumatic Stress Disorder Research
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Treatments and Studies
- Cancer-related molecular mechanisms research
- Psychological Well-being and Life Satisfaction
King's College London
2021-2024
Fujian Provincial Cancer Hospital
2024
Fujian Medical University
2024
Southern Medical University
2021-2024
National Institute for Health Research
2021-2023
Maudsley Hospital
2021-2023
National Cheng Kung University
2006
National Taiwan University
2006
Abstract Background The impact of the coronavirus disease 2019 (COVID-19) pandemic on mental health is still being unravelled. It important to identify which individuals are at greatest risk worsening symptoms. This study aimed examine changes in depression, anxiety and post-traumatic stress disorder (PTSD) symptoms using prospective retrospective symptom change assessments, find effect key factors. Method Online questionnaires were administered 34 465 (aged 16 years or above) April/May 2020...
Understanding and improving outcomes for people with anxiety or depression often requires large sample sizes. To increase participation reduce costs, such research is typically unable to utilise "gold-standard" methods ascertain diagnoses, instead relying on remote, self-report measures. Assess the comparability of remote diagnostic disorders commonly used in research. Participants from UK-based GLAD COPING NBR cohorts (N = 58,400) completed an online questionnaire between 2018 2020....
Abstract Objective The disruption caused by the COVID‐19 pandemic has been associated with poor mental health, including increases in eating disorders and self‐harm symptoms. We investigated risk protective factors for new onset of these symptoms during pandemic. Method Data were from Psychiatry Neurological Genetics study Repeated Assessment Mental health Pandemics Study ( n = 36,715). Exposures socio‐demographic characteristics, lifetime psychiatric disorder, COVID‐related variables,...
Background Mismatch repair proficient colorectal cancer (pMMR CRC) lacks effective treatments and has a poor prognosis, which can be attributed to the complexity of tumor microenvironment. The coordinated function immune cells is vital anti-tumor immunity. However, spatial characteristics in pMMR CRC microenvironment their relationship with clinical prognosis are not fully understood. Meanwhile, modulatory effect neoadjuvant chemotherapy (NCT), first-line treatment CRC, needs further...
Background: The COVID-19 pandemic is a novel population-level stressor. As such, it important to examine pandemic-related changes in mental health and identify which individuals are at greatest risk of worsening symptoms.Methods: Online questionnaires were administered 34,465 the UK, recruited from existing cohorts or via social media. Around one third (n = 12,718) with prior diagnoses depression anxiety completed pre-pandemic assessments, allowing prospective investigation symptom change....
Abstract Despite the observed associations between psychiatric disorders and nutrient intake, genetic studies are limited. We examined whether polygenic scores for associated with intake in UK Biobank ( N = 163,619) using linear mixed models. found attention-deficit/hyperactivity disorder, bipolar schizophrenia showed highest number of associations, while a score autism spectrum disorder no association. The relatively weaker obsessive-compulsive greatest effect sizes suggesting its...
Abstract Objectives People with bipolar disorder who also report binge eating have increased psychopathology and greater impairment than those without eating. Whether this co‐occurrence is related to as a symptom or presents differently across full‐syndrome disorders unclear. Methods We first compared networks of 13 lifetime mania symptoms in 34,226 participants from the United Kingdom's National Institute for Health Care Research BioResource ( n = 12,104) 22,122) Second, subsample eating,...
Abstract Antidepressants are the most common treatment for moderate or severe depression. Side effects crucial indicators antidepressants, but their occurrence varies widely among individuals. In this study, we leveraged genetic and medical data from self-reported questionnaires in Genetic Links to Anxiety Depression (GLAD) study build prediction models of side subsequent discontinuation across three antidepressant classes (SSRI, SNRI, tricyclic (TCA)) at first last (most recent) year...
The study of biomolecular interactions is critical for understanding various biological processes. Atomic force microscopy (AFM) has now become a common method studying interactions. Such experiments typically generate large amounts curves, and manually analyzing these data extremely time-consuming prone to subjective biases. Many algorithms have been proposed the automatic processing curves. However, existing primarily focus on searching events in limited functionality differentiating...
Human papillomavirus (HPV)-positive head and neck squamous cell carcinoma (HNSCC) is an increasingly common malignancy. We aimed to explore the immune heterogeneity of natural killer (NK) cells in HPV-positive HNSCC. Single-cell RNA-sequencing (scRNA-seq) bulk datasets HNSCC data were obtained from Gene Expression Omnibus (GEO) database. "Seurat", "harmony", "SingleR" used perform scRNA-seq analysis. Subsequently, "cellphonedb" package was for crosstalk analysis, "clusterProfiler" hallmark...
Progress towards stratified care for anxiety and depression will require the identification of new predictors. We collected data on retrospectively self-reported therapeutic outcomes in adults who received psychological therapy UK past ten years. aimed to replicate factors associated with traditional treatment outcome measures from literature.
P-757 Introduction: Depression has become an important psychiatric condition and health burden globally. Prevalence of depression mood disease is unclear in working population Taiwan. This study develops methods measurements for surveillance disorder workers Methods: Study participants were recruited from 5 traditional industries, 13 medical institutions, 7 fire fighting departments representative areas The Center Epidemiological Studies-Depression Scales (CES-D) Chinese version AUDIT...
Abstract Background Understanding and improving outcomes for people with anxiety or depression often requires large studies. To increase participation reduce costs, such research is typically unable to utilise “gold-standard” methods ascertain diagnoses, instead relying on remote, self-report measures. Aims assess the comparability of remote diagnostic disorders commonly used in research. Method Participants from UK-based GLAD COPING NBR cohorts ( N = 58,400) completed an online...