A5055772647- Eating Disorders and Behaviors
- Cognitive Abilities and Testing
- Mental Health Research Topics
- Child and Adolescent Psychosocial and Emotional Development
- Bipolar Disorder and Treatment
- COVID-19 and Mental Health
- Obesity, Physical Activity, Diet
- Genetics and Neurodevelopmental Disorders
- Autism Spectrum Disorder Research
- Health, Environment, Cognitive Aging
- Genetic Associations and Epidemiology
- Child Nutrition and Feeding Issues
- Obesity and Health Practices
- Machine Learning in Healthcare
- Treatment of Major Depression
- Bayesian Modeling and Causal Inference
- Delphi Technique in Research
- Pharmacogenetics and Drug Metabolism
- Family Support in Illness
- Long-Term Effects of COVID-19
- Behavioral Health and Interventions
- Data Quality and Management
- Bioinformatics and Genomic Networks
- Suicide and Self-Harm Studies
- Topic Modeling
King's College London
2020-2025
South London and Maudsley NHS Foundation Trust
2022-2024
National Institute for Health Research
2022
Maudsley Hospital
2022
Karolinska Institutet
2020
Abstract Objective The disruption caused by the COVID‐19 pandemic has been associated with poor mental health, including increases in eating disorders and self‐harm symptoms. We investigated risk protective factors for new onset of these symptoms during pandemic. Method Data were from Psychiatry Neurological Genetics study Repeated Assessment Mental health Pandemics Study ( n = 36,715). Exposures socio‐demographic characteristics, lifetime psychiatric disorder, COVID‐related variables,...
Abstract Objective Individuals meeting all criteria for anorexia nervosa (AN) except that weight falls within or above the normal range despite significant loss are categorized as having atypical AN (AAN). Existing research has provided mixed evidence concerning diagnostic demarcation of and AAN. The aim present study was to identify priorities furthering understanding AAN entities. Method Employing Delphi methodology, experts in field were invited suggest questions need be explored from...
Anxiety and depressive disorders often co-occur the order of their emergence may be associated with different clinical outcomes. However, minimal research has been conducted on anxiety-anxiety comorbidity. This study examined factors anxiety comorbidity anxiety-MDD temporal sequence. Online, self-report data were collected from UK-based GLAD COPING NBR cohorts (N = 38,775). Logistic regression analyses compared differences in sociodemographic, trauma, between single anxiety, comorbidity,...
Abstract Background Anorexia nervosa (AN) is a severe disorder, for which genetic evidence suggests psychiatric as well metabolic origins. AN has high somatic and comorbidities, broad impact on quality of life, elevated mortality. Risk factor studies have focused differences between acutely ill recovered individuals. Such comparisons often yield ambiguous conclusions, alterations could reflect different effects depending the comparison. Whereas found in patients state that are due to acute...
Abstract Antidepressants are the most common treatment for moderate or severe depression. Side effects crucial indicators antidepressants, but their occurrence varies widely among individuals. In this study, we leveraged genetic and medical data from self-reported questionnaires in Genetic Links to Anxiety Depression (GLAD) study build prediction models of side subsequent discontinuation across three antidepressant classes (SSRI, SNRI, tricyclic (TCA)) at first last (most recent) year...
Abstract The genetic relationship between schizophrenia, IQ, and educational attainment (EA) is complex. Schizophrenia polygenic scores (PGS) are linked to lower whilst higher IQ-PGS correlates with reduced schizophrenia risk. Paradoxically, predisposition EA has been associated increased risk, a potentially confounded by overlap bipolar disorder. Through Genomic Structural Equation Modelling we dissected the contribution identifying 63 SNPs uniquely (SZspecific) 78 shared disorder...
Abstract Background This paper introduces the UK Biobank (UKB) second mental health questionnaire (MHQ2), describes its design, respondents and some notable findings. UKB is a large cohort study with over 500,000 volunteer participants aged 40-69 years when recruited in 2006-2010. It an important resource of extensive health, genetic biomarker data. Enhancements to enrich data available. MHQ2 enhancement designed enable facilitate research psychosocial aspects. Methods sent link by email...
Abstract Objective Bipolar disorder typically features episodes of mania and depression, frequently accompanied by psychosis. While progress has been made in understanding the genetics depression psychosis, remains underexplored. Methods We employed Genomic Structural Equation Modeling to subtract genetic effects schizophrenia major depressive (MDD) from bipolar identify a trait specific mania. Results The SEM model revealed significant loadings for “mania” (0.67, p<0.001), “psychosis”...
Abstract Objective The United Kingdom Eating Disorders Genetics Initiative (EDGI UK), part of the National Institute for Health and Care Research (NIHR) Mental BioResource, aims to deepen our understanding environmental genetic etiology eating disorders. EDGI UK launched in February 2020 is partnered with disorders charity, Beat. Multiple branches exist worldwide. This article serves dual function providing an in‐depth description study protocol describing initial sample including...
Objective: The disruption caused by the COVID-19 pandemic has been associated with poor mental health, including increases in eating disorder and self-harm symptoms. We investigated risk protective factors for new onset of these symptoms during pandemic. Method: Data were from Psychiatry Neurological Genetics study Repeated Assessment Mental health Pandemics Study (n = 45,058). Exposures socio-demographic characteristics, lifetime psychiatric disorder, COVID-related variables, SARS-CoV-2...
Abstract Objective The Eating Disorders Genetics Initiative United Kingdom (EDGI UK), part of the National Institute for Health and Care Research (NIHR) Mental BioResource, aims to deepen our understanding environmental genetic aetiology eating disorders. EDGI UK launched in February 2020 is partnered with disorders charity, Beat. There are multiple branches worldwide. Method recruits via media clinical services. Anyone living England, at least 16 years old, a lifetime probable or disorder...
Objective: The disruption caused by the COVID-19 pandemic has been associated with poor mental health, including increases in eating disorder and self-harm symptoms. We investigated risk protective factors for new onset of these symptoms during pandemic. Method: Data were from Psychiatry Neurological Genetics study Repeated Assessment Mental health Pandemics Study (n = 45,058). Exposures socio-demographic characteristics, lifetime psychiatric disorder, COVID-related variables, SARS-CoV-2...