A5042518784- Genetic Associations and Epidemiology
- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Epigenetics and DNA Methylation
- Nutrition, Genetics, and Disease
- Genetic Mapping and Diversity in Plants and Animals
- Cancer-related molecular mechanisms research
- Pancreatitis Pathology and Treatment
- Health, Environment, Cognitive Aging
- Cancer Risks and Factors
- BRCA gene mutations in cancer
- Genomic variations and chromosomal abnormalities
- Health Systems, Economic Evaluations, Quality of Life
- Family Support in Illness
- Diet and metabolism studies
- Genetic Syndromes and Imprinting
- Cancer-related gene regulation
- Cancer, Lipids, and Metabolism
- Autism Spectrum Disorder Research
Université de Lille
2022-2025
Institut Pasteur de Lille
2022-2024
Inserm
2022-2024
Centre National de la Recherche Scientifique
2022-2024
King's College London
2024
European Genomic Institute for Diabetes
2022-2024
University of Surrey
2023
Depression is a common comorbidity of type 2 diabetes. We assessed the causal relationships and shared genetics between them.We applied two-sample, bidirectional Mendelian randomization (MR) to assess causality diabetes depression. investigated potential mediation using two-step MR. To identify genetics, we performed 1) genome-wide association studies (GWAS) separately 2) multiphenotype GWAS (MP-GWAS) (19,344 case subjects, 463,641 control subjects) depression major depressive disorder (MDD)...
Type 2 diabetes (T2D) and hypertension are common health conditions that often occur together, suggesting shared biological mechanisms. To explore this relationship, we analysed large-scale multiomic data to uncover genetic factors underlying T2D blood pressure (BP) comorbidity. We curated 1,304 independent single-nucleotide variants (SNVs) associated with T2D/BP, grouping them into five clusters related metabolic syndrome, inverse T2D-BP risk, impaired pancreatic beta-cell function, higher...
<title>Abstract</title> Major depressive disorder (MDD) is a significant contributor to the burden of mental disorders in Africa, necessitating an understanding its prevalence and risk factors across diverse socio-cultural contexts address health disparities improve care. This cross-sectional study analyzed 7,073 adult participants from hospital settings Uganda, Kenya, Ethiopia, South Africa within NeuroGAP-Psychosis study. Prevalence estimates, calculated with 95% confidence intervals,...
Abstract Obesity and type 2 diabetes (T2D) are associated with increased risk of pancreatic cancer. Here we assessed the relationship between cancer two distinct measures obesity, namely total adiposity, using BMI, versus abdominal BMI adjusted waist-to-hip ratio (WHRadjBMI) by utilising polygenic scores (PGS) Mendelian randomisation (MR) analyses. We constructed z-score weighted PGS for WHRadjBMI publicly available data tested their association defined in UK biobank (UKBB). Using summary...
Polygenic score (PGS) is a valuable method for assessing the estimated genetic liability to given outcome or variability contributing quantitative trait. While polygenic risk scores are widely used complex traits, their application in uncovering shared predisposition between phenotypes, i.e., when variants influence more than one phenotype, remains limited. We developed an R package, comorbidPGS, which facilitates systematic evaluation of effects among (cor)related phenotypes using PGSs. The...
Abstract Background This paper introduces the UK Biobank (UKB) second mental health questionnaire (MHQ2), describes its design, respondents and some notable findings. UKB is a large cohort study with over 500,000 volunteer participants aged 40-69 years when recruited in 2006-2010. It an important resource of extensive health, genetic biomarker data. Enhancements to enrich data available. MHQ2 enhancement designed enable facilitate research psychosocial aspects. Methods sent link by email...
Abstract Background Type 2 diabetes (T2D) increases the risk of pancreatic ductal adenocarcinoma (PDAC), which could be due to an epigenetic mechanism. Methods We explored association between T2D and whole pancreas methylation in 141 individuals, 28 had T2D, using Illumina MethylationEPIC 850K BeadChip arrays. performed downstream functional assessment rat acinar cell line AR42J. To further understand role our candidate gene humans, we tested whether null variants were associated with...
<p>OBJECTIVE. Depression is a common co-morbidity of type 2 diabetes. We assessed the causal relationships and shared genetics between them.</p> <p>RESEARCH DESIGN AND METHODS. applied two-sample bi-directional Mendelian randomization (MR) to assess causality diabetes depression. investigated potential mediation using two-step MR. To identify genetics, we performed 1) GWAS, separately, 2) multi-phenotype GWAS (MP-GWAS) (cases=19,344, controls=463,641) depression, major...
<p>OBJECTIVE. Depression is a common co-morbidity of type 2 diabetes. We assessed the causal relationships and shared genetics between them.</p> <p>RESEARCH DESIGN AND METHODS. applied two-sample bi-directional Mendelian randomization (MR) to assess causality diabetes depression. investigated potential mediation using two-step MR. To identify genetics, we performed 1) GWAS, separately, 2) multi-phenotype GWAS (MP-GWAS) (cases=19,344, controls=463,641) depression, major...
Abstract Obesity and type 2 diabetes (T2D) are associated with increased risk of pancreatic cancer. Here we assessed the relationship between cancer two distinct measures obesity, namely total adiposity, using BMI, versus abdominal, BMI adjusted waist-to-hip ratio (WHRadjBMI) polygenic scores (PGS) Mendelian randomization (MR). We constructed z-score weighted PGS for WHRadjBMI publicly available data tested their association defined in UK biobank (UKBB). Using summary statistics then...
Abstract OBJECTIVE Depression is a common co-morbidity of type 2 diabetes. However, the causality and underlying mechanisms remain unclear. RESEARCH DESIGN AND METHODS We applied bi-directional Mendelian randomization (MR) to assess between diabetes self-reported depression. Using UK biobank, we performed 1) GWAS, separately, 2) multi-phenotype GWAS (MP-GWAS) (cases=19,344, controls=463,641) depression, using two depression definitions–clinically diagnosed major depressive disorder (MDD,...
ABSTRACT OBJECTIVE Diverse measures of obesity relate to cancer risk differently. Here we assess the relationship between overall and central adiposity cancer. METHODS We constructed z-score weighted polygenic scores (PGS) for two obesity-related phenotypes; body mass index (BMI) BMI adjusted waist-to-hip ratio (WHRadjBMI) tested their association with five cancers in UK Biobank: breast (BrC), post-menopausal (PostBrC), prostate (PrC), colorectal (CrC) lung (LungC) utilised publicly...