A5040291344- Pancreatic and Hepatic Oncology Research
- Pancreatic function and diabetes
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Pancreatitis Pathology and Treatment
- Genetic Associations and Epidemiology
- Diabetes Treatment and Management
- Health, Environment, Cognitive Aging
- BRCA gene mutations in cancer
- Metabolism, Diabetes, and Cancer
- Lipoproteins and Cardiovascular Health
- Cancer-related gene regulation
- Birth, Development, and Health
- Cancer, Lipids, and Metabolism
- Cancer Risks and Factors
- Nutrition, Genetics, and Disease
- Assisted Reproductive Technology and Twin Pregnancy
- Prenatal Screening and Diagnostics
Université de Lille
2022-2024
University of Surrey
2022-2024
European Genomic Institute for Diabetes
2022-2024
Institut Pasteur de Lille
2022-2024
Inserm
2022-2024
Centre National de la Recherche Scientifique
2022-2024
Genomics (United Kingdom)
2024
Imperial College London
2024
Adverse pregnancy outcomes, such as sporadic and recurrent miscarriages stillbirths, are significant medical concerns, impacting up to 15% of clinically recognised pregnancies. These outcomes highly complex multifactorial, with 50% cases classified idiopathic, highlighting a substantial gap in our understanding their biological basis. Along external risk factors, polygenic variability contributes idiopathic loss, suggesting that large-scale genetic studies could offer insights into its...
Type 2 diabetes (T2D) and hypertension are common health conditions that often occur together, suggesting shared biological mechanisms. To explore this relationship, we analysed large-scale multiomic data to uncover genetic factors underlying T2D blood pressure (BP) comorbidity. We curated 1,304 independent single-nucleotide variants (SNVs) associated with T2D/BP, grouping them into five clusters related metabolic syndrome, inverse T2D-BP risk, impaired pancreatic beta-cell function, higher...
Abstract Obesity and type 2 diabetes (T2D) are associated with increased risk of pancreatic cancer. Here we assessed the relationship between cancer two distinct measures obesity, namely total adiposity, using BMI, versus abdominal BMI adjusted waist-to-hip ratio (WHRadjBMI) by utilising polygenic scores (PGS) Mendelian randomisation (MR) analyses. We constructed z-score weighted PGS for WHRadjBMI publicly available data tested their association defined in UK biobank (UKBB). Using summary...
We postulated that type 2 diabetes (T2D) predisposes patients to exocrine pancreatic diseases through (epi)genetic mechanisms. explored the methylome (using MethylationEPIC arrays) of pancreas in 141 donors, assessing impact T2D. An epigenome-wide association study T2D identified hypermethylation an enhancer lipase–related protein 1 (PNLIPRP1) gene, associated with decreased PNLIPRP1 expression. null variants (found 191,000 participants UK Biobank) were elevated glycemia and LDL cholesterol....
Polygenic score (PGS) is a valuable method for assessing the estimated genetic liability to given outcome or variability contributing quantitative trait. While polygenic risk scores are widely used complex traits, their application in uncovering shared predisposition between phenotypes, i.e., when variants influence more than one phenotype, remains limited. We developed an R package, comorbidPGS, which facilitates systematic evaluation of effects among (cor)related phenotypes using PGSs. The...
<p dir="ltr"><b>Abstract:</b></p><p dir="ltr">We postulated that T2D predisposes to exocrine pancreatic diseases through (epi)genetic mechanisms. We explored the methylome (methylationEPIC arrays) of pancreas 141 donors, assessing impact T2D. Epigenome-wide association study (EWAS) for identified a hypermethylation in an enhancer Pancreatic-Lipase-Related-Protein 1 (<i>PNLIPRP1</i>) gene, associated with decreased <i>PNLIPRP1</i>...
<p dir="ltr"><b>Abstract:</b></p><p dir="ltr">We postulated that T2D predisposes to exocrine pancreatic diseases through (epi)genetic mechanisms. We explored the methylome (methylationEPIC arrays) of pancreas 141 donors, assessing impact T2D. Epigenome-wide association study (EWAS) for identified a hypermethylation in an enhancer Pancreatic-Lipase-Related-Protein 1 (<i>PNLIPRP1</i>) gene, associated with decreased <i>PNLIPRP1</i>...
Abstract Background Type 2 diabetes (T2D) increases the risk of pancreatic ductal adenocarcinoma (PDAC), which could be due to an epigenetic mechanism. Methods We explored association between T2D and whole pancreas methylation in 141 individuals, 28 had T2D, using Illumina MethylationEPIC 850K BeadChip arrays. performed downstream functional assessment rat acinar cell line AR42J. To further understand role our candidate gene humans, we tested whether null variants were associated with...
Abstract Obesity and type 2 diabetes (T2D) are associated with increased risk of pancreatic cancer. Here we assessed the relationship between cancer two distinct measures obesity, namely total adiposity, using BMI, versus abdominal, BMI adjusted waist-to-hip ratio (WHRadjBMI) polygenic scores (PGS) Mendelian randomization (MR). We constructed z-score weighted PGS for WHRadjBMI publicly available data tested their association defined in UK biobank (UKBB). Using summary statistics then...
ABSTRACT OBJECTIVE Diverse measures of obesity relate to cancer risk differently. Here we assess the relationship between overall and central adiposity cancer. METHODS We constructed z-score weighted polygenic scores (PGS) for two obesity-related phenotypes; body mass index (BMI) BMI adjusted waist-to-hip ratio (WHRadjBMI) tested their association with five cancers in UK Biobank: breast (BrC), post-menopausal (PostBrC), prostate (PrC), colorectal (CrC) lung (LungC) utilised publicly...