A5068039462- Child and Adolescent Psychosocial and Emotional Development
- Resilience and Mental Health
- Early Childhood Education and Development
- Mental Health Research Topics
- Cognitive Abilities and Testing
- Genetic Associations and Epidemiology
- Stress Responses and Cortisol
- Mental Health Treatment and Access
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health, Environment, Cognitive Aging
- Eating Disorders and Behaviors
- Evaluation and Performance Assessment
- Bullying, Victimization, and Aggression
- Neuroendocrine regulation and behavior
- Youth Education and Societal Dynamics
- Tryptophan and brain disorders
- Memory and Neural Mechanisms
- Aging and Gerontology Research
- Autism Spectrum Disorder Research
- Birth, Development, and Health
- Health disparities and outcomes
King's College London
2019-2024
National Institute for Health Research
2019
Maudsley Hospital
2019
The Twins Early Development Study (TEDS) is a longitudinal study following cohort of twins born 1994-1996 in England and Wales. Of the 13,759 families who originally consented to take part, over 10,000 remain enrolled study. current focus TEDS on mental health mid-twenties. Making use 25 years genetically sensitive data, uniquely placed explore genetic environmental influences common disorders early adulthood. This paper outlines recent data collection efforts supporting this work, including...
Anxiety and depression are common, debilitating costly. These disorders influenced by multiple risk factors, from genes to psychological vulnerabilities environmental stressors, but research is hampered a lack of sufficiently large comprehensive studies. We recruiting 40,000 individuals with lifetime or anxiety broad assessment risks facilitate future research. The Genetic Links Depression (GLAD) Study (www.gladstudy.org.uk) recruits into the NIHR Mental Health BioResource. Participants...
Background Emotional symptoms, such as anxiety and depressive are common during adolescence, often persist over time, can precede the emergence of severe disorders. Studies suggest that a vicious cycle reciprocal influences between emotional symptoms interpersonal difficulties may explain why some adolescents suffer from persisting symptoms. However, role different types difficulties, social isolation peer victimisation, in these associations is still unclear. In addition, lack longitudinal...
Background: Conduct problems trajectory studies suggest their development is highly heterogeneous and that different trajectories may be uniquely associated with risk factors outcomes. Yet combining modelling a varied set of genetic early-life factors, as well adult outcomes, are scarce. Methods: We analysed data from the Twins Early Development Study (TEDS), longitudinal UK twin cohort (N=18,993). were measured using parent reports Strengths Difficulties Questionnaire (SDQ) conduct subscale...
Objective: This study aimed to identify and categorise under-recognised weight loss behaviours in individuals with eating disorders, addressing diagnostic gaps. Method: We text mined free-text responses from 1,675 participants anorexia nervosa, bulimia or binge-eating disorder the Genetic Links Anxiety Depression (GLAD) Study United Kingdom Eating Disorders Genetics Initiative (EDGI UK). In secondary analyses, we investigated differences by gender. Results: Frequently endorsed included...
Background: Anxiety is one of the most common conditions affecting young people. The onset and course symptoms are highly variable across development if left untreated, can lead to poor outcomes. We modelled trajectories anxiety from childhood early adulthood examined associated predictors adult Method: analysed data Twins Early Development Study, a UK-based longitudinal twin cohort (N = 13,965). were assessed using items Strengths Difficulties Questionnaire ages 4 26. Growth mixture...
Objectives We aimed to examine differences in fear conditioning between anxious and nonanxious participants a single large sample. Materials methods employed remote task (FLARe) collect data from the Twins Early Development Study (n = 1,146; 41% vs. 59% nonanxious). Differences groups were estimated for their expectancy of an aversive outcome towards reinforced conditional stimulus (CS+) unreinforced (CS−) during acquisition extinction phases. Results During acquisition, group (vs. group)...
Abstract Greater environmental sensitivity has been associated with increased risk of mental health problems, especially in response to stressors, and lower levels subjective wellbeing. Conversely, also correlates emotional problems the absence adversity, positive influences. Additionally, found correlate positively autistic traits. Individual differences are partly heritable, but it is unknown what extent aetiological factors underlying overlap those on (anxiety depressive symptoms), traits...
Background Despite being considered a measure of environmental risk, reported life events are partly heritable. One mechanism that may contribute to this heritability is genetic influences on sensitivity, relating how individuals process and interpret internal external signals. The aim study was explore the overlap between self‐reported measures sensitivity. Methods At age 17, 2,939 from Twins Early Development Study (TEDS) completed anxiety sensitivity (Children's Anxiety Sensitivity...
Abstract Background Anxiety and depression are common, debilitating costly. These disorders influenced by multiple risk factors, from genes to psychological vulnerabilities environmental stressors but research is hampered a lack of sufficiently large comprehensive studies. We recruiting 40,000 individuals with lifetime or anxiety, broad assessment risks facilitate future research. Methods The Genetic Links Depression (GLAD) Study ( www.gladstudy.org.uk ) recruits anxiety into the NIHR Mental...
Background: Anxiety is one of the most common conditions affecting young people. The onset and course symptoms are highly variable across development if left untreated, can lead to poor outcomes. We modelled trajectories anxiety from childhood early adulthood examined associated predictors adult Method: analysed data Twins Early Development Study, a UK-based longitudinal twin cohort (N = 13,965). were assessed using Strengths Difficulties Questionnaire ages 4 26. Growth mixture modelling was...
Background: Anxiety is one of the most common conditions affecting young people. The onset and course symptoms are highly variable across development if left untreated, can lead to poor outcomes. We modelled trajectories anxiety from childhood early adulthood examined associated predictors adult Method: analysed data Twins Early Development Study, a UK-based longitudinal twin cohort (N = 13,965). were assessed using items Strengths Difficulties Questionnaire ages 4 26. Growth mixture...
Abstract Background Despite being considered a measure of environmental risk, reported life events are partly heritable. One mechanism that may contribute to their heritability is genetic influences on sensitivity. These sensitivity biases can relate how individuals process the contextual aspects environment (environmental sensitivity) or they interpret own physical and emotional responses (anxiety sensitivity). The aim this study was explore overlap between self-reported measures Methods At...