A5026464483- Nanoplatforms for cancer theranostics
- Literary Theory and Cultural Hermeneutics
- Ultrasound and Hyperthermia Applications
- Pancreatic function and diabetes
- Cancer Cells and Metastasis
- Cancer, Stress, Anesthesia, and Immune Response
- Diabetes Treatment and Management
- Historical Philosophy and Science
- Literature: history, themes, analysis
- Advanced biosensing and bioanalysis techniques
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- Metabolism, Diabetes, and Cancer
- Australian History and Society
- Eosinophilic Disorders and Syndromes
- Cytokine Signaling Pathways and Interactions
- Phytoestrogen effects and research
- Seaweed-derived Bioactive Compounds
- Nanowire Synthesis and Applications
- Mental Health Treatment and Access
- Borges, Kipling, and Jewish Identity
- Themes in Literature Analysis
- Philosophy, History, and Historiography
- Travel Writing and Literature
- Electrolyte and hormonal disorders
University of Ulster
2008-2023
King's College London
2019
Pace University
2015
The University of Texas at San Antonio
1990
Anxiety and depression are common, debilitating costly. These disorders influenced by multiple risk factors, from genes to psychological vulnerabilities environmental stressors, but research is hampered a lack of sufficiently large comprehensive studies. We recruiting 40,000 individuals with lifetime or anxiety broad assessment risks facilitate future research. The Genetic Links Depression (GLAD) Study (www.gladstudy.org.uk) recruits into the NIHR Mental Health BioResource. Participants...
The major unmet need and crucial challenge hampering the exciting potential of RNAi therapeutics in ophthalmology is to find an effective, safe non-invasive means delivering siRNA cornea. Although all tissues eye are accessible by injection, topical application preferable for frequent treatment regimen that would be necessary siRNA-induced gene silencing. However, ocular surface one more complex biological barriers drug delivery due combined effect short contact time, tear dilution poor...
Structural biomarkers determined by X-ray scattering of the tissues can complement conventional diagnostics and provide a pathway for early detection diseases. In present study, mouse models were utilized to observe progress prostate cancer. We induced cancer in left lobe prostate, whilst right was uninoculated. The mice sacrificed at several time points (Days 2, 4, 7, 16 after inoculation), lobes analyzed using scattering. Control samples also collected from healthy same points. This...
Abstract Purpose Sonodynamic therapy (SDT) is emerging as a cancer treatment alternative with significant advantages over conventional therapies, including its minimally invasive and site-specific nature, radical antitumour efficacy minimal side effects, capacity to raise an immune response. The study explores the of SDT in combination nanotechnology against pancreatic ductal adenocarcinoma. Methods A nanoparticulate formulation (HPNP) based on cathepsin B-degradable glutamate-tyrosine...
Absolute or relative hyperglucagonaemia is a characteristic of both Type 1 and 2 diabetes, resulting in fasting hyperglycaemia due part to increased hepatic glucose production lack postprandial suppression circulating glucagon concentrations. Consequently, therapeutics that target secretion biological action may be effective antidiabetic agents. In this regard, specific receptor (GCGR) antagonists have been developed exhibit impressive glucose-lowering actions, but unfortunately cause...
When discussing the Romanticism of Persuasion, long regarded as most Romantic Jane Austen's novels, critics usually make comparisons with lyric in one or other its forms. Barbara Hardy, for example, writes that chapter 10 novel, which describes autumnal walk to Winthrop, brings us close romantic ode: This nearly episode, she argues, resembles an Ode Autumn three stanzas way it presents changing response heroine, Anne Elliot, a landscape whose character changes at successive stages walk. Nina...
Within mammalian pancreatic islets, there are two major endocrine cell types, beta-cells which secrete insulin and alpha-cells glucagon. Whereas, acts to lower circulating glucose, glucagon counters this by increasing glucose via the mobilisation of glycogen. Synthalin A (Syn A) was subject much research in 1920s 1930s as a potential alpha-cell toxin block secretion. However, with discovery its lifesaving use patients diabetes, on Syn-A discontinued.This short review looks back early studies...
Abstract Background Pancreatic cancer remains a significant therapeutic challenge and its poor prognosis has remained relatively unchanged for the past 40 years. tumours are highly desmoplastic impenetrable lesions in which both gas mass transfer is severely compromised. This leads to development of hypoxia within tumour this compromises approaches that rely on cytotoxic reactive oxygen species, e.g. photodynamic therapy, sonodynamic therapy radiotherapy. Hypoxia also results low pH...
Abstract Background The emergence of immune checkpoint inhibitors (ICI’s) in the past decade has proven transformative area immuno-oncology. PD-1 / PD-L1 axis been particularly well studied and monoclonal antibodies developed to block either receptor (anti PD-1) or its associated ligand PD-L1) can generate potent anti-tumour immunity certain tumour models. However, many “immune cold” tumours remain unresponsive ICI’s. Sonodynamic therapy (SDT) is a targeted anti-cancer treatment that uses...
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