A5031315153- Phytochemicals and Antioxidant Activities
- Edible Oils Quality and Analysis
- Antioxidant Activity and Oxidative Stress
- Cholesterol and Lipid Metabolism
- Free Radicals and Antioxidants
- Neurological Disease Mechanisms and Treatments
- Genomics, phytochemicals, and oxidative stress
- Gut microbiota and health
- Phytoestrogen effects and research
- Nutritional Studies and Diet
- Seaweed-derived Bioactive Compounds
- Ginkgo biloba and Cashew Applications
- Probiotics and Fermented Foods
- Diet and metabolism studies
- Synthesis of Organic Compounds
- Medicinal Plants and Bioactive Compounds
- Natural Compound Pharmacology Studies
- Essential Oils and Antimicrobial Activity
- Medicinal plant effects and applications
- Potato Plant Research
- Biochemical Analysis and Sensing Techniques
- Biochemical effects in animals
- Microbial Metabolites in Food Biotechnology
- Phytochemical Studies and Bioactivities
- Biochemical and biochemical processes
University of Roehampton
2015-2023
University of Milan
2022
University of Reading
2009-2018
Cambridge University Press
2010-2011
New York University Press
2010-2011
University of Cagliari
2005-2009
Istituto Nazionale di Fisica Nucleare, Sezione di Cagliari
2007-2009
Università degli Studi del Piemonte Orientale “Amedeo Avogadro”
2008
The influence of the gut microbiota on brain chemistry has been convincingly demonstrated in rodents. In absence bacteria, central expression derived neurotropic factor, (BDNF), and N-methyl-d-aspartate receptor (NMDAR) subunits are reduced, whereas, oral probiotics increase BDNF, impart significant anxiolytic effects. We tested whether prebiotic compounds, which intrinsic enteric microbiota, also affected BDNF NMDARs. addition, we examined plasma from treated rats released human SH-SY5Y...
We have conducted a detailed investigation into the absorption, metabolism and microflora-dependent transformation of hydroxytyrosol (HT), tyrosol (TYR) their conjugated forms, such as oleuropein (OL). Conjugated forms underwent rapid hydrolysis under gastric conditions, resulting in significant increases amount free HT TYR entering small intestine. Both transferred across human Caco-2 cell monolayers rat segments jejunum ileum were subject to classic phase I/II biotransformation. The major...
Abstract The fruit of the date palm ( Phoenix dactylifera L.) is a rich source dietary fibre and polyphenols. We have investigated gut bacterial changes induced by whole extract (digested extract; DDE) its polyphenol-rich (date polyphenol DPE) using faecal, pH-controlled, mixed batch cultures mimicking distal part human large intestine, utilising an array microbial group-specific 16S rRNA oligonucleotide probes. Fluorescence microscopic enumeration indicated that there was significant...
Abstract Brown seaweeds such as Ascophyllum nodosum are a rich source of phlorotannins (oligomers and polymers phloroglucinol units), class polyphenols that unique to Phaeophyceae. At present, there is no information on the bioavailability seaweed limited evidence their bioactivity in vivo . Consequently, we investigated gastrointestinal modifications vitro from A. effect inflammatory markers healthy participants. In , some phlorotannin oligomers were identified after digestion colonic...
Oats contain a range of phenolic acids and avenanthramides which may have health benefits. Analysis 22 commercial oat products (oat bran concentrate, bran, flaked oats, rolled oats oatcakes) using HPLC-DAD detected eleven bound thirteen free + conjugated avenanthramides. The (excluding concentrate) provided between 15.79 25.05 mg total (9.9–19.33 bound, 4.96–5.72 conjugated) 1.1 2 in 40 g portion while an 11 concentrate 16.7 (15.17 1.53 1.2 compositions concentrations the components...
Abstract Extra virgin olive oil is rich in phenolic compounds which are believed to exert beneficial effects against many pathological processes, including the development of colon cancer. We show that one major polyphenolic constituents extra oil, hydroxytyrosol (HT), exerts strong antiproliferative human adenocarcinoma cells via its ability induce a cell cycle block G2/M. These were preceded by inhibition extracellular signal‐regulated kinase (ERK)1/2 phosphorylation and downstream...
The secoiridoids 3,4-dihydroxyphenylethanol-elenolic acid (3,4-DHPEA-EA) and dialdehyde (3,4-DHPEA-EDA) account for approximately 55 % of the phenolic content olive oil may be partly responsible its reported human health benefits. We have investigated absorption metabolism these in upper gastrointestinal tract. Both 3,4-DHPEA-EDA 3,4-DHPEA-EA were relatively stable under gastric conditions, only undergoing limited hydrolysis. transferred across a cellular model small intestine (Caco-2...
The leaves of the olive plant ( Olea europaea ) are rich in polyphenols, which oleuropein and hydroxytyrosol (HT) most characteristic. Such polyphenols have been demonstrated to favourably modify a variety cardiovascular risk factors. aim present intervention was investigate influence leaf extract (OLE) on vascular function inflammation postprandial setting link physiological outcomes with absorbed phenolics. A randomised, double-blind, placebo-controlled, cross-over, acute trial conducted...
Abstract The degeneration of dopaminergic neurons in the substantia nigra has been linked to formation endogenous neurotoxin 5‐ S ‐cysteinyl‐dopamine. Sulforaphane (SFN), an isothiocyanate derived from corresponding precursor glucosinolate found cruciferous vegetables observed exert a range biological activities various cell populations. In this study, we show that SFN protects primary cortical against ‐cysteinyl‐dopamine induced neuronal injury. Pre‐treatment with (0.01–1 μM) resulted...
Unlike other classes of polyphenols, there is a lack knowledge regarding brown seaweed phlorotannins and their bioactivity. We investigated the impact in vitro gastrointestinal digestion colonic fermentation on bioactivity phlorotannin extract from Ascophyllum nodosum its high molecular weight (HMW) low (LMW) fractions.
Bioavailability studies in animals and humans fed with extravirgin olive oil demonstrated that hydroxytyrosol tyrosol, the major simple phenolic compounds oil, are dose-dependently absorbed excreted. Once absorbed, they undergo extensive metabolism; tyrosol concentrate mainly kidney, where may exert an important role prevention of oxidative stress induced renal dysfunction. In this study we monitored ability to protect cells (LLC-PK1) following damage by H 2 O . Oxidative was evaluated...
Abstract Specific flavonoid-rich foods/beverages are reported to exert positive effects on vascular function; however, data relating in the postprandial state limited. The present study investigated postprandial, time-dependent (0–7 h) impact of citrus flavanone intake function. An acute, randomised, controlled, double-masked, cross-over intervention was conducted by including middle-aged healthy men (30–65 years, n 28) assess (orange juice: 128·9 mg; flavanone-rich orange 272·1 homogenised...
The olive oil polyphenol, hydroxytyrosol (HT), is believed to be capable of exerting protection against oxidative kidney injury. In this study we have investigated the ability HT and its O-methylated metabolite, homovanillic alcohol (HVA) protect renal cells damage induced by hydrogen peroxide. We show that both compounds were inhibiting peroxide-induced cell injury via an interact with MAP kinase PI3 signalling pathways, albeit at different concentrations. strongly inhibited death prevented...
Evidence suggests that a combination of oxidative stress, neuroinflammation and the formation endogenous neurotoxins contribute to underlying neuronal death associated with neurodegenerative diseases. In this study we have investigated abi