A5004085499- CRISPR and Genetic Engineering
- Animal Genetics and Reproduction
- Renal and related cancers
- Immune Response and Inflammation
- Neonatal Respiratory Health Research
- Climate Change and Health Impacts
- Medical and Biological Ozone Research
- Antimicrobial Peptides and Activities
- Asthma and respiratory diseases
- RNA Interference and Gene Delivery
- Pancreatic function and diabetes
- Pneumonia and Respiratory Infections
- Studies on Chitinases and Chitosanases
- Pediatric health and respiratory diseases
- Immune cells in cancer
- Extracellular vesicles in disease
- NF-κB Signaling Pathways
- Nanoplatforms for cancer theranostics
- Hydrogen's biological and therapeutic effects
- Protein Hydrolysis and Bioactive Peptides
- Spaceflight effects on biology
- Eosinophilic Esophagitis
- S100 Proteins and Annexins
Fudan University
2024
Zhongshan Hospital
2024
Shanghai First People's Hospital
2019-2021
Shanghai Jiao Tong University
2019-2021
Abstract Background Macrophage polarization and reprogramming in the lung play a critical role initiation, development progression of acute injury (ALI). Regulating activation differentiation pulmonary macrophages may provide potential therapeutic strategy to treat ALI. We previously developed novel class anti-inflammatory nanoparticles (P12) that can potently inhibit Toll-like receptor (TLR) signaling macrophages. These bioactive nanodevices were made gold (GNPs) coated with hexapeptides...
Abstract Toll‐like receptor (TLR) activation in macrophages plays a critical role the pathogenesis of acute lung injury (ALI). While TLR inhibition is promising strategy to control overwhelming inflammation ALI, there still lacks effective inhibitors for clinical uses date. A unique class peptide‐coated gold nanoparticles (GNPs) previously discovered, which effectively inhibited signaling and protected mice from lipopolysaccharide (LPS)‐induced ALI. To fast translate such discovery into...
Overwhelming uncontrolled inflammation is the hallmark of pathophysiological features many acute and chronic inflammatory diseases, such as sepsis allergy autoimmune disorders. It important to develop potent pharmacological interventions effectively control detrimental reactions in these diseases. Recently, we have developed a special class peptide-gold nanoparticle hybrid system that can inhibit Toll-like receptor 4 (TLR4) signal transduction pathways decrease its downstream responses....
Abstract Background Heat shock protein (HSP) 20 is a molecular chaperone that exerts multiple protective functions in various kinds of tissues. However, the expression HSP20 and its specific airway epithelial cells (AECs) remain elusive. Results In current study, we first confirmed inducible mouse AECs human bronchial cell line BEAS-2B cells, under different oxidant stressors. Then by establishing HSP20-abundant model with repeated low-level-ozone exposures stimulating this single high-level...
<title>Abstract</title> Progesterone plays a crucial and indispensable role in regulating immunity attenuating inflammation. Nestorone <sup>®</sup> (NES, segesterone acetate) is steroidal progestin 19-norprogesterone derivative with no -CH3 group radical at the 6-position. Here, we showed that NES enhanced viability of lipopolysaccharide (LPS)-stimulated THP-1 cell-derived macrophages, potently inhibiting both arms Toll-like receptor 4 (TLR-4) signaling cascade triggered by LPS, especially...
Progesterone plays a crucial and indispensable role in regulating immunity attenuating inflammation. Nestorone® (NES, segesterone acetate) is steroidal progestin 19-norprogesterone derivative with no -CH3 group radical at the 6-position. Here, we showed that NES enhanced viability of lipopolysaccharide (LPS)-stimulated THP-1 cell-derived macrophages, potently inhibiting both arms Toll-like receptor 4 (TLR-4) signaling cascade triggered by LPS, especially TLR-4/MyD88/NF-κB pathway. In...
ΦC31 integrase, a site-specific recombinase, can efficiently target attB-bearing transgenes to endogenous pseudo attP sites within mammalian genomes. The sequence features of binding will help us fully understand the recognition function by integrase. present study was aimed uncover global map integrase in bovine cells and analysis these comprehensive bioinformatics methods. In this study, we constructed ChIP-seq method that be used phiC31 6740 potential were identified. A motif found...
Additional file 1. figures describe the zeta-potential of P12, anti-inflammatory activities P12 in LPS-induced ALI mice at different doses, culture procedure and purity BMDMs, viability M1 M2 macrophages by treatment, changes macrophage percentage lung tissues upon treatment immunofluorescence imaging.