A5101868884- SARS-CoV-2 and COVID-19 Research
- Kidney Stones and Urolithiasis Treatments
- Single-cell and spatial transcriptomics
- Gene expression and cancer classification
- Pediatric Urology and Nephrology Studies
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Poxvirus research and outbreaks
- Histone Deacetylase Inhibitors Research
- COVID-19 Clinical Research Studies
- Immunotherapy and Immune Responses
- Female Genital Mutilation/Cutting Issues
- Bacteriophages and microbial interactions
- Gout, Hyperuricemia, Uric Acid
- Peptidase Inhibition and Analysis
- Law in Society and Culture
- Autophagy in Disease and Therapy
- Genital Health and Disease
- Influenza Virus Research Studies
- Climate Change Policy and Economics
- Monoclonal and Polyclonal Antibodies Research
- Protein Degradation and Inhibitors
- Inflammasome and immune disorders
- Herpesvirus Infections and Treatments
- RNA modifications and cancer
First Affiliated Hospital of Fujian Medical University
2020-2025
Fujian Medical University
2020-2025
Pudong Medical Center
2023-2025
Fudan University
2023-2025
Anhui University of Traditional Chinese Medicine
2023-2025
State Key Laboratory of Genetic Engineering
2023-2024
Taipei Medical University
2017-2024
Academia Sinica
2020-2024
Peking Union Medical College Hospital
2017-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2024
Spatial transcriptome technique was applied to decipher the spatial architecture and TME characteristics of liver cancers.
Molecular heterogeneities and complex microenvironments bring great challenges for cancer diagnosis treatment. Recent advances in single-cell RNA-sequencing (scRNA-seq) technology make it possible to study cell at transcriptomic level. Here, we develop an R package named scCancer, which focuses on processing analyzing scRNA-seq data research. Except basic steps, this takes several special considerations cancer-specific features. Firstly, the introduced comprehensive quality control metrics....
Newly emerged SARS-CoV-2 variants like JN.1, and more recently, the hypermutated BA.2.87.1, have raised global concern. We recruited two groups of participants who had BA.5/BF.7 breakthrough infection post three doses inactivated vaccines: one group experienced subsequent XBB reinfection, while other received XBB-containing trivalent WSK-V102C vaccine. Our comparative analysis their serum neutralization activities revealed that vaccine induced stronger antibody responses against a wide range...
Abstract Histone deacetylases (HDAC) contain eighteen isoforms that can be divided into four classes. Of these isoform enzymes, class IIa (containing HDAC4, 5, 7 and 9) target unique substrates, some of which are client proteins associated with epigenetic control. Class HDACs reportedly neuronal disorders, making therapeutic targets for treating neurodegenerative diseases. Additionally, reported HDAC inhibitors hydroxamate moiety chelates zinc ion to become the cofactor enzymes. However,...
Tafolecimab is a novel fully human proprotein convertase subtilisin/kexin type 9 (PCSK9) monoclonal antibody, developed for the treatment of hypercholesterolemia. To assess efficacy and safety tafolecimab in Chinese patients at high or very cardiovascular risk with Patients diagnoses heterozygous familial hypercholesterolemia (HeFH) by Simon Broome criteria nonfamilial hypercholesterolemia, screening low-density lipoprotein cholesterol (LDL-C) level ≥1.8 mmol/L, were randomized 2:1 to...
<sec><title>Objective</title> To analyze the association of serum heparin-binding protein (HBP) and C-reactive (CRP) levels with urosepsis following flexible ureteroscopic lithotripsy (FURL) to construct a back propagation neural network prediction model. </sec><sec><title>Methods</title> A total 428 patients kidney stones who underwent FURL were enrolled. Patients divided into sepsis group (<italic>n</italic>=42) control (<italic>n</italic>=386) according whether post-operative developed....
Background The interaction between illness perception, self-care ability, and health-promoting behaviors (HPB) in stable coronary artery disease (SCAD) patients remains uncertain. We conducted a cross-sectional survey to explore the correlation HPB among with SCAD, as well potential mediating role of perception ability HPB. Methods A study was carried out 184 inpatients SCAD Hefei, China, from December 2022 March 2023. Self-Care Coronary Heart Disease Inventory (SC-CHDI, containing three...
Abstract Background The monkeypox virus (MPXV) has raised global health concerns due to its widespread transmission. This study evaluated the MPXV immunogenic antigens and impact of vaccinia (VACV) vaccination infection on cross-reactive antibody responses conserved proteins from representative strains that reflected evolutionary trajectory. Methods Phylogenetic analyses were first conducted reveal trajectory 1970 2024. A total 84 serum samples collected: 42 VACV-vaccinated individuals, 12...
Taohong Siwu decoction (TSD) is a classic traditional Chinese medicine (TCM) prescription used to promote the blood circulation and alleviate stasis. TSD consists of Paeonia lactiflora Pall., Conioselinum anthriscoides (H. Boissieu) Pimenov & Kljuykov, Rehmannia glutinosa (Gaertn.) DC., Prunus persica (L.) Batsch, Angelica sinensis (Oliv.) Diels, Carthamus creticus L. in ratio 3:2:4:3:3:2. Studies on effects myocardial ischemia-reperfusion injury (MIRI) from perspective autophagy pyroptosis...
The rapid mutation of SARS-CoV-2 has led to multiple rounds large-scale breakthrough infection and reinfection worldwide. However, the dynamic changes humoral cellular immunity responses several subvariants after remain unclear. In our study, a 6-month longitudinal immune response evaluation was conducted on 118 sera 50 PBMC samples from 49 healthy individuals who experienced BA.5/BF.7/XBB or BA.5/BF.7-XBB reinfection. By studying antibody response, memory B cell, IFN-γ secreting CD4+/CD8+ T...
Stone disease is one of the most common afflictions in modern society. Complications following retrograde intrarenal surgery (RIRS) vary considerably, and small-diameter ureteral access sheaths are reportedly significantly associated with rates infectious complications RIRS. This study aimed to explore additional risk factors for after RIRS.This retrospectively analyzed 602 patients who underwent RIRS between December 2016 October 2019 at First Affiliated Hospital Fujian Medical University....
Background: Hypertrophy of the labia minora with lateral clitoral hood redundancy is common, but excess often overlooked during labiaplasty, which may result in imbalanced and unsatisfactory outcomes. The purpose this study was to present an easy method three-step excision for composite reduction. Methods: procedure performed three steps: prominent skin parallel majora sulcus removed first; then, protuberant portion by wedge resection; finally, a triangle at junction between trimmed....
Abstract As the SARS-CoV-2 virus continues to evolve, novel XBB sub-lineages such as XBB.1.5, XBB.1.16, EG.5, HK.3 (FLip), and XBB.2.3, well most recent BA.2.86, have been identified aroused global concern. Understanding efficacy of current vaccines immune system’s response these emerging variants is critical for public health. In this study, we evaluated neutralization activities sera from participants who received COVID-19 inactivated vaccines, or a booster vaccination recently approved...
Abstract Background Erectile dysfunction (ED) is a common condition affecting middle-aged and elderly men. Aim The study sought to investigate differentially expressed fatty acid metabolism–related genes the molecular mechanisms of ED. Methods expression profiles GSE2457 GSE31247 were downloaded from Gene Expression Omnibus database merged. Differentially (DEGs) between ED normal samples obtained using R package limma. Ontology Kyoto Encyclopedia Genes Genomes enrichment analyses DEGs...
Actinomycosis is a chronic granulomatous disease that can affect various parts of the body, including head and neck, lungs, abdominal pelvic cavities, wounds. It caused by different actinomycetes like Actinomyces sherdii, glasii, cariosa, zurichensis, europaea. Reported infections include pulmonary actinomycosis, infections, bone or artificial joint endocarditis, complicated urinary tract soft tissue abscesses. The combination actinomycosis with gastric cancer exceptionally rare in clinical...
Objective: To evaluate the efficacy and safety of a novel tip-flexible suction ureteral access sheath (NTFS-UAS) combined with flexible ureteroscopic lithotripsy (FURS) for treating kidney stones ≥30 mm in large cohort. Methods: The clinical data 206 patients renal calculi treated by NTFS-UAS FURS from June 2021 to September 2023 were analyzed retrospectively. outcomes under investigation encompassed demographic information, stone-related characteristics, operative time, stone-free rates...
Alzheimer's disease (AD) is a progressive neurodegenerative disorder with multiple etiologies. Beta-amyloid (Aβ) self-aggregation and overexpression of class IIa histone deacetylases (HDACs) are strongly implicated AD pathogenesis. In this study, series novel diarylheptanoid derivatives were designed, synthesized evaluated for use as dual Aβ HDAC inhibitors. Among these compounds, 4j, 5c 5e displayed effective inhibitions self-aggregation, HDAC5 activity HDAC7 IC50 values < 10 µM. The...
Existing classifications of the clitoral hood-labia minora complex (CLC) have neglected its integrity and anatomic variation, resulting in failure to optimize approaches tailored individuals.The aim this study was present a new classification system for comprehensive evaluation variations CLC introduce simple surgical approach fused type.Anatomic were classified into 3 types: isolated labia or lateral hood hypertrophy (Type 1); conventional combined 2); 3). A modified procedure type...